PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27899434-10 2018 Following the resolution of the concussion-evoked cephalic hypersensitivity, administration of GTN produced a renewed and pronounced cephalic pain hypersensitivity that was inhibited by sumatriptan or anti-CGRP antibody treatment as well as a CGRP-dependent CPA. Nitroglycerin 95-98 calcitonin-related polypeptide alpha Rattus norvegicus 206-210 32745488-11 2020 Besides, OrxA (100 pM) decreased NTG-induced CGRP upregulation. Nitroglycerin 33-36 calcitonin-related polypeptide alpha Rattus norvegicus 45-49 32745488-12 2020 The data revealed that the activation of Orx1Rs in the vlPAG is effective in relieving NTG-induced migraine symptoms mainly by the downregulation of CGRP in the Vc of rats. Nitroglycerin 87-90 calcitonin-related polypeptide alpha Rattus norvegicus 149-153 31420791-7 2019 The results showed that NTG induced EEG and behavior disorders in rats, which was associated with the initiation of oxidative stress and increased expression of CGRP. Nitroglycerin 24-27 calcitonin-related polypeptide alpha Rattus norvegicus 161-165 30003352-0 2018 Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing. Nitroglycerin 52-65 calcitonin-related polypeptide alpha Rattus norvegicus 123-127 30003352-10 2018 RESULTS: NTG administration induced spinal hyperalgesia and orofacial allodynia, together with a significant increase in the expression of CGRP and c-Fos genes in trigeminal ganglia and central areas. Nitroglycerin 9-12 calcitonin-related polypeptide alpha Rattus norvegicus 139-143 32686605-10 2020 Besides, NTG administration increased CGRP expression in the Vc of rats. Nitroglycerin 9-12 calcitonin-related polypeptide alpha Rattus norvegicus 38-42 32639078-7 2022 Methanandamide attenuated nitroglycerin-induced CGRP increments in in-vivo plasma, trigeminal ganglia and brainstem and also in ex-vivo hemiskull preparations. Nitroglycerin 26-39 calcitonin-related polypeptide alpha Rattus norvegicus 48-52 31707574-5 2020 Anti-inflammatory thymoquinone ameliorated GTN-stimulated CGRP levels in plasma, and migraine-related structures including trigeminal ganglion and brainstem; moreover, thymoquinone inhibited degranulation of MMCs and prevented the increase in the number of MMCs in GTN-induced in vivo migraine model. Nitroglycerin 43-46 calcitonin-related polypeptide alpha Rattus norvegicus 58-62 31885641-0 2019 Auricular Electrical Stimulation Alleviates Headache through CGRP/COX-2/TRPV1/TRPA1 Signaling Pathways in a Nitroglycerin-Induced Migraine Rat Model. Nitroglycerin 108-121 calcitonin-related polypeptide alpha Rattus norvegicus 61-65 31885641-7 2019 The CGRP, COX-2, TRPV1, and TRPA1 immunoreactive cells in the trigeminal ganglion increased in the NTG group compared with the control group (all p < 0.0001); this increase could, however, be reduced by auricular ES pretreatment (27.8 +- 2.6 vs 63.0 +- 4.2, p < 0.0001; 21.7 +- 1.2 vs 61.8 +- 4.0, p < 0.0001; 24.3 +- 1.0 vs 36.5 +- 1.7, p=0.0003; and 20.7 +- 1.9 vs 90.8 +- 6.5, p < 0.0001, respectively). Nitroglycerin 99-102 calcitonin-related polypeptide alpha Rattus norvegicus 4-8 29237283-0 2018 Ghrelin attenuated hyperalgesia induced by chronic nitroglycerin: CGRP and TRPV1 as targets for migraine management. Nitroglycerin 51-64 calcitonin-related polypeptide alpha Rattus norvegicus 66-70 29344989-9 2018 The results showed that GTN triggered the increase in CGRP levels in plasma, trigeminal ganglion neurons and ex vivo meningeal preparations. Nitroglycerin 24-27 calcitonin-related polypeptide alpha Rattus norvegicus 54-58 27899434-10 2018 Following the resolution of the concussion-evoked cephalic hypersensitivity, administration of GTN produced a renewed and pronounced cephalic pain hypersensitivity that was inhibited by sumatriptan or anti-CGRP antibody treatment as well as a CGRP-dependent CPA. Nitroglycerin 95-98 calcitonin-related polypeptide alpha Rattus norvegicus 243-247 27899434-12 2018 Conclusions Concussion leads to the development of headache and pain-related behaviours, in particular sustained enhanced responses to GTN, that are mediated through a CGRP-dependent mechanism. Nitroglycerin 135-138 calcitonin-related polypeptide alpha Rattus norvegicus 168-172 24783932-7 2014 In the nitroglycerin-induced migraine group, after gavage for 7 days, rats were intraperitoneally injected nitroglycerin (10 mg/kg), and 4 h later, blood samples were collected from postcava for measuring the plasma CGRP and beta-EP levels. Nitroglycerin 7-20 calcitonin-related polypeptide alpha Rattus norvegicus 216-220 27919017-7 2017 Results KYNA-A1 abolished NTG-induced hyperalgesia in both pain models; NTG alone or associated to formalin injection induced an increased mRNA expression of CGRP, nNOS and cytokines in the trigeminal ganglia and central areas, which was reduced by KYNA-A1. Nitroglycerin 72-75 calcitonin-related polypeptide alpha Rattus norvegicus 158-162 25892078-7 2015 In the present study, the expression of p-ERK, CGRP and COX-2 was detected in the dura mater, trigeminal ganglion (TG) and spinal trigeminal nucleus caudalis in NTG-induced rats and ESTG models by immunohistochemistry. Nitroglycerin 161-164 calcitonin-related polypeptide alpha Rattus norvegicus 47-51 24895375-1 2015 BACKGROUND AND AIMS: Calcitonin gene-related peptide (CGRP) and glyceryl trinitrate (GTN) infusion in migraineurs provokes headache resembling spontaneous migraine, and CGRP receptor antagonists are effective in the treatment of acute migraine. Nitroglycerin 85-88 calcitonin-related polypeptide alpha Rattus norvegicus 169-173 24998872-0 2014 Correlation between algogenic effects of calcitonin-gene-related peptide (CGRP) and activation of trigeminal vascular system, in an in vivo experimental model of nitroglycerin-induced sensitization. Nitroglycerin 162-175 calcitonin-related polypeptide alpha Rattus norvegicus 41-72 24998872-3 2014 The present study was addressed to investigate CGRP-evoked behavior in nitric oxide (NO) sensitized rats, using an experimental model of nitroglycerin induced sensitization of trigeminal system, looking at neuropeptide release from different cerebral areas after the intra-peritoneal (i.p.) Nitroglycerin 137-150 calcitonin-related polypeptide alpha Rattus norvegicus 47-51 24998872-6 2014 On the contrary, CGRP injected in animals pre-treated with 10mg/kg nitroglycerin significantly increased the time spent in face rubbing. Nitroglycerin 67-80 calcitonin-related polypeptide alpha Rattus norvegicus 17-21 24998872-9 2014 treatment with nitroglycerin produced an increase of CGRP levels in brainstem and trigeminal ganglia, but not in the hypothalamus and hippocampus. Nitroglycerin 15-28 calcitonin-related polypeptide alpha Rattus norvegicus 53-57 24998872-10 2014 The absolute amounts of CGRP produced in the brainstem were lower compared to those in the trigeminal ganglion; however, after nitroglycerin stimulation the percentage increase was higher in the brainstem. Nitroglycerin 127-140 calcitonin-related polypeptide alpha Rattus norvegicus 24-28 26729049-8 2016 administration of nitroglycerine produces an increase in CGRP levels in the brainstem and trigeminal ganglia, which is inhibited by a pre-treatment with lacosamide. Nitroglycerin 18-32 calcitonin-related polypeptide alpha Rattus norvegicus 57-61 24366981-0 2014 Effects of CGRP receptor antagonism in nitroglycerin-induced hyperalgesia. Nitroglycerin 39-52 calcitonin-related polypeptide alpha Rattus norvegicus 11-15 24366981-3 2014 AIM: The aim of this article is to test the analgesic effect of the CGRP receptor antagonist MK-8825 in two animal models of pain that may be relevant for migraine: the tail flick test and the formalin test performed during NTG-induced hyperalgesia. Nitroglycerin 224-227 calcitonin-related polypeptide alpha Rattus norvegicus 68-72 24366981-5 2014 Furthermore, the CGRP antagonist proved effective in counteracting NTG-induced hyperalgesia in both tests. Nitroglycerin 67-70 calcitonin-related polypeptide alpha Rattus norvegicus 17-21 24004534-0 2013 Changes in calcitonin gene-related peptide (CGRP) receptor component and nitric oxide receptor (sGC) immunoreactivity in rat trigeminal ganglion following glyceroltrinitrate pretreatment. Nitroglycerin 155-173 calcitonin-related polypeptide alpha Rattus norvegicus 11-42 24000375-0 2014 Nitric oxide synthase, calcitonin gene-related peptide and NK-1 receptor mechanisms are involved in GTN-induced neuronal activation. Nitroglycerin 100-103 calcitonin-related polypeptide alpha Rattus norvegicus 23-54 24000375-2 2014 Here we analyse the effect of nitric oxide synthase (NOS) and calcitonin gene-related peptide (CGRP) systems on the GTN-induced neuronal activation in this model. Nitroglycerin 116-119 calcitonin-related polypeptide alpha Rattus norvegicus 62-93 24000375-2 2014 Here we analyse the effect of nitric oxide synthase (NOS) and calcitonin gene-related peptide (CGRP) systems on the GTN-induced neuronal activation in this model. Nitroglycerin 116-119 calcitonin-related polypeptide alpha Rattus norvegicus 95-99 24000375-6 2014 RESULTS: GTN-treated rats showed a significant increase of nNOS and CGRP in dura mater and CGRP in the trigeminal nucleus caudalis (TNC). Nitroglycerin 9-12 calcitonin-related polypeptide alpha Rattus norvegicus 68-72 24000375-6 2014 RESULTS: GTN-treated rats showed a significant increase of nNOS and CGRP in dura mater and CGRP in the trigeminal nucleus caudalis (TNC). Nitroglycerin 9-12 calcitonin-related polypeptide alpha Rattus norvegicus 91-95 24000375-10 2014 CONCLUSION: The present study indicates that blockers of CGRP, NOS and NK-1 receptors all inhibit GTN induced Fos activation. Nitroglycerin 98-101 calcitonin-related polypeptide alpha Rattus norvegicus 57-61 24256609-0 2013 The calcitonin gene-related peptide receptor antagonist MK-8825 decreases spinal trigeminal activity during nitroglycerin infusion. Nitroglycerin 108-121 calcitonin-related polypeptide alpha Rattus norvegicus 4-35 24256609-3 2013 In animal experiments nitrovasodilators like nitroglycerin induced increases in spinal trigeminal activity, which were reversed after inhibition of CGRP receptors. Nitroglycerin 45-58 calcitonin-related polypeptide alpha Rattus norvegicus 148-152 24256609-4 2013 In the present study we asked if CGRP receptor inhibition can also prevent spinal trigeminal activity induced by nitroglycerin. Nitroglycerin 113-126 calcitonin-related polypeptide alpha Rattus norvegicus 33-37 24256609-9 2013 CONCLUSIONS: CGRP receptors may be important in an early phase of nitroglycerin-induced central trigeminal activity. Nitroglycerin 66-79 calcitonin-related polypeptide alpha Rattus norvegicus 13-17 24693369-2 2013 The purpose of this study was to investigate the effect of BTX-A on the immunoreactive levels of calcitonin gene-related peptide (CGRP) and substance P (SP) in the jugular plasma and medulla oblongata of migraine in rats induced by nitroglycerin (NTG), and then to evaluate and compare the effectiveness of fixed (muscle)-sites and acupoint-sites injection of BTX-A for migraine therapy of patients in a randomly controlled trial extending over four months. Nitroglycerin 232-245 calcitonin-related polypeptide alpha Rattus norvegicus 97-128 24693369-2 2013 The purpose of this study was to investigate the effect of BTX-A on the immunoreactive levels of calcitonin gene-related peptide (CGRP) and substance P (SP) in the jugular plasma and medulla oblongata of migraine in rats induced by nitroglycerin (NTG), and then to evaluate and compare the effectiveness of fixed (muscle)-sites and acupoint-sites injection of BTX-A for migraine therapy of patients in a randomly controlled trial extending over four months. Nitroglycerin 247-250 calcitonin-related polypeptide alpha Rattus norvegicus 97-128 24693369-6 2013 RESULTS: Local BTX-A injection suppressed NTG-induced CGRP-LI and SP-LI levels in jugular plasma and oblongata. Nitroglycerin 42-45 calcitonin-related polypeptide alpha Rattus norvegicus 54-58 24693369-9 2013 CONCLUSIONS: The evidence that BTX-A decreases NTG-induced CGRP-LI and SP-LI levels in trigeminovascular system suggests that BTX-A attenuates migraine by suppression of neuropeptide release. Nitroglycerin 47-50 calcitonin-related polypeptide alpha Rattus norvegicus 59-63 21331665-0 2011 Effects of heating coagulation of middle meningeal artery on plasma CGRP level and c-fos expression in migraine rat triggered by nitroglycerin. Nitroglycerin 129-142 calcitonin-related polypeptide alpha Rattus norvegicus 68-72 22539824-11 2012 CGRP receptors in the trigeminal ganglion may influence neuronal activity evoked by mechanical stimulation of meningeal afferents only after pretreatment with GTN. Nitroglycerin 159-162 calcitonin-related polypeptide alpha Rattus norvegicus 0-4 21331665-7 2011 Heat coagulation of middle meningeal artery may ameliorate sufferings of rat induced by NTG and play an important role in restraining the release of CGRP as well as the activation of neurons in trigeminal nucleus caudalis in rats following NTG infusion. Nitroglycerin 240-243 calcitonin-related polypeptide alpha Rattus norvegicus 149-153 21331665-5 2011 We found that NTG led to markedly increase in plasma CGRP level and c-fos expression in trigeminal nucleus caudalis compared with the isotonic saline-treated group (P < 0.05). Nitroglycerin 14-17 calcitonin-related polypeptide alpha Rattus norvegicus 53-57 19744475-1 2009 Four hours after systemic administration of the nitric oxide donor nitroglycerin (10 mg/kg bodyweight, s.c.), the neurons of the rat caudal trigeminal nucleus are activated, the area covered by calcitonin gene-related peptide (CGRP)-immunoreactive fibres is decreased and the neuronal nitric oxide synthase (nNOS)- and the calmodulin-dependent protein kinase II alpha (CamKIIalpha)-immunopositive neurons in the same area are increased. Nitroglycerin 67-80 calcitonin-related polypeptide alpha Rattus norvegicus 194-225 19864020-0 2009 Glyceroltrinitrate facilitates stimulated CGRP release but not gene expression of CGRP or its receptor components in rat trigeminal ganglia. Nitroglycerin 0-18 calcitonin-related polypeptide alpha Rattus norvegicus 42-46 21809559-0 2011 [Heat coagulation of middle meningeal artery affects plasma CGRP and substance P levels in migraine rat triggered by nitroglycerin]. Nitroglycerin 117-130 calcitonin-related polypeptide alpha Rattus norvegicus 60-64 21809559-1 2011 OBJECTIVE: To detect the influence of heat coagulation of middle meningeal artery (MMA) on plasma CGRP and SP levels in migraine rat triggered by nitroglycerin (NTG). Nitroglycerin 146-159 calcitonin-related polypeptide alpha Rattus norvegicus 98-102 21809559-1 2011 OBJECTIVE: To detect the influence of heat coagulation of middle meningeal artery (MMA) on plasma CGRP and SP levels in migraine rat triggered by nitroglycerin (NTG). Nitroglycerin 161-164 calcitonin-related polypeptide alpha Rattus norvegicus 98-102 21809559-10 2011 CONCLUSION: Heat coagulation of MMA may relieve symptoms of rats following nitroglycerin infusion, possibly by inhibiting the release of CGRP and SP. Nitroglycerin 75-88 calcitonin-related polypeptide alpha Rattus norvegicus 137-141 20974582-1 2011 BACKGROUND: Nitrovasodilators, such as glyceroltrinitrate (GTN), which produce nitric oxide (NO) in the organism, are known to cause delayed headaches in migraineurs, accompanied by increased plasma levels of calcitonin gene-related peptide (CGRP) in the cranial venous outflow. Nitroglycerin 39-57 calcitonin-related polypeptide alpha Rattus norvegicus 209-240 20974582-1 2011 BACKGROUND: Nitrovasodilators, such as glyceroltrinitrate (GTN), which produce nitric oxide (NO) in the organism, are known to cause delayed headaches in migraineurs, accompanied by increased plasma levels of calcitonin gene-related peptide (CGRP) in the cranial venous outflow. Nitroglycerin 39-57 calcitonin-related polypeptide alpha Rattus norvegicus 242-246 20974582-1 2011 BACKGROUND: Nitrovasodilators, such as glyceroltrinitrate (GTN), which produce nitric oxide (NO) in the organism, are known to cause delayed headaches in migraineurs, accompanied by increased plasma levels of calcitonin gene-related peptide (CGRP) in the cranial venous outflow. Nitroglycerin 59-62 calcitonin-related polypeptide alpha Rattus norvegicus 209-240 20974582-1 2011 BACKGROUND: Nitrovasodilators, such as glyceroltrinitrate (GTN), which produce nitric oxide (NO) in the organism, are known to cause delayed headaches in migraineurs, accompanied by increased plasma levels of calcitonin gene-related peptide (CGRP) in the cranial venous outflow. Nitroglycerin 59-62 calcitonin-related polypeptide alpha Rattus norvegicus 242-246 20974582-7 2011 RESULTS: The proportions of CGRP- and nNOS- as well as double-immunopositive neurons were increased after GTN infusion compared to saline treatment in all parts of the trigeminal ganglion (CGRP) or restricted to the ophthalmic region (nNOS). Nitroglycerin 106-109 calcitonin-related polypeptide alpha Rattus norvegicus 28-32 20974582-7 2011 RESULTS: The proportions of CGRP- and nNOS- as well as double-immunopositive neurons were increased after GTN infusion compared to saline treatment in all parts of the trigeminal ganglion (CGRP) or restricted to the ophthalmic region (nNOS). Nitroglycerin 106-109 calcitonin-related polypeptide alpha Rattus norvegicus 189-193 19925620-0 2010 Kynurenate derivative attenuates the nitroglycerin-induced CamKIIalpha and CGRP expression changes. Nitroglycerin 37-50 calcitonin-related polypeptide alpha Rattus norvegicus 75-79 19925620-1 2010 OBJECTIVE: To examine the efficacy of L-kynurenine and a novel kynurenic acid derivative on the nitroglycerin-induced calmodulin-dependent protein kinase II alpha (CamKIIalpha) and calcitonin gene-related peptide (CGRP) expression changes in the rat caudal trigeminal nucleus. Nitroglycerin 96-109 calcitonin-related polypeptide alpha Rattus norvegicus 181-212 19925620-1 2010 OBJECTIVE: To examine the efficacy of L-kynurenine and a novel kynurenic acid derivative on the nitroglycerin-induced calmodulin-dependent protein kinase II alpha (CamKIIalpha) and calcitonin gene-related peptide (CGRP) expression changes in the rat caudal trigeminal nucleus. Nitroglycerin 96-109 calcitonin-related polypeptide alpha Rattus norvegicus 214-218 19925620-3 2010 In the rat, nitroglycerin activates second-order neurons in the caudal trigeminal nucleus, and increases expression of the CamKIIalpha and decreases that of the CGRP there. Nitroglycerin 12-25 calcitonin-related polypeptide alpha Rattus norvegicus 161-165 19925620-9 2010 Results.- L-kynurenine and 2-(2-N,N-dimethylaminoethylamine-1-carbonyl)-1H-quinolin-4-one hydrochloride pretreatment attenuated the nitroglycerin-induced changes in CamKIIalpha and CGRP immunoreactivity in the rat caudal trigeminal nucleus. Nitroglycerin 132-145 calcitonin-related polypeptide alpha Rattus norvegicus 181-185 19744475-1 2009 Four hours after systemic administration of the nitric oxide donor nitroglycerin (10 mg/kg bodyweight, s.c.), the neurons of the rat caudal trigeminal nucleus are activated, the area covered by calcitonin gene-related peptide (CGRP)-immunoreactive fibres is decreased and the neuronal nitric oxide synthase (nNOS)- and the calmodulin-dependent protein kinase II alpha (CamKIIalpha)-immunopositive neurons in the same area are increased. Nitroglycerin 67-80 calcitonin-related polypeptide alpha Rattus norvegicus 227-231 19744475-3 2009 Accordingly, the aim of the present experiments was to examine the effects of probenecid administration on the nitroglycerin-induced expressions of nNOS, CamKIIalpha and CGRP in the rat caudal trigeminal nucleus. Nitroglycerin 111-124 calcitonin-related polypeptide alpha Rattus norvegicus 170-174 19744475-6 2009 The data suggest that the changes caused by nitroglycerin in the expressions of CGRP, nNOS and CamKIIalpha can be influenced by probenecid modulating the inflammatory functions in the nervous system. Nitroglycerin 44-57 calcitonin-related polypeptide alpha Rattus norvegicus 80-84 19002537-0 2009 Nitroglycerin protects small intestine from ischemia-reperfusion injury via NO-cGMP pathway and upregulation of alpha-CGRP. Nitroglycerin 0-13 calcitonin-related polypeptide alpha Rattus norvegicus 118-122 19576883-9 2009 The change of plasma CGRP level positively correlated with the change of nitroglycerin-induced hypotensive effects. Nitroglycerin 73-86 calcitonin-related polypeptide alpha Rattus norvegicus 21-25 19576883-12 2009 The change of CGRP release from the rings positively correlated with the nitroglycerin-induced vasodilator responses. Nitroglycerin 73-86 calcitonin-related polypeptide alpha Rattus norvegicus 14-18 19576883-13 2009 The present results suggest that both GST and ALDH-2 are involved in nitroglycerin action while ALDH-2 plays a major role, and the change of CGRP contents closely correlates with the biotransformation of nitroglycerin. Nitroglycerin 69-82 calcitonin-related polypeptide alpha Rattus norvegicus 141-145 19576883-13 2009 The present results suggest that both GST and ALDH-2 are involved in nitroglycerin action while ALDH-2 plays a major role, and the change of CGRP contents closely correlates with the biotransformation of nitroglycerin. Nitroglycerin 204-217 calcitonin-related polypeptide alpha Rattus norvegicus 141-145 18584896-0 2009 Delayed anti-arrhythmic effect of nitroglycerin in anesthetized rats: involvement of CGRP, PKC and mK ATP channels. Nitroglycerin 34-47 calcitonin-related polypeptide alpha Rattus norvegicus 85-89 18584896-8 2009 These results show that a low dose of NTG has a delayed anti-arrhythmic effect and this effect may share a common mechanism with anti-infarct effects of this drug, involving CGRP release and PKC and mK(ATP) activation. Nitroglycerin 38-41 calcitonin-related polypeptide alpha Rattus norvegicus 174-178 19002537-5 2009 The effects of nitric oxide (NO), cGMP, and alpha-calcitonin gene-related peptide (CGRP) synthesis on the effects of NTG were analyzed. Nitroglycerin 117-120 calcitonin-related polypeptide alpha Rattus norvegicus 83-87 19002537-10 2009 Reverse-transcription polymerase chain reaction analysis showed that NTG upregulates the expression of alpha-CGRP messenger RNA (mRNA), but not beta-CGRP mRNA in lumbar dorsal root ganglia. Nitroglycerin 69-72 calcitonin-related polypeptide alpha Rattus norvegicus 109-113 19121572-7 2009 Besides, for the nitroglycerin-induced headache rats, the c-fos gene expression in the brain stem and hypothalamus was remarkably inhibited and the level of plasma CGRP was reduced significantly after CXVO administration at both doses 90.0 and 135.0 microg/kg. Nitroglycerin 17-30 calcitonin-related polypeptide alpha Rattus norvegicus 164-168 14729435-0 2004 Delayed cardioprotection afforded by nitroglycerin is mediated by alpha-CGRP via activation of inducible nitric oxide synthase. Nitroglycerin 37-50 calcitonin-related polypeptide alpha Rattus norvegicus 72-76 18647185-12 2008 In anesthetized rats glibenclamide significantly attenuated CGRP induced dural and TES induced dural/pial artery dilatation (P = .001; P = .001; P = .005), but had no effect on dural/pial vasodilatation induced by GTN. Nitroglycerin 214-217 calcitonin-related polypeptide alpha Rattus norvegicus 60-64 18695513-3 2008 CGRP was not significantly different from normal saline in inducing face-grooming behavior but NTG facilitated the effect of CGRP. Nitroglycerin 95-98 calcitonin-related polypeptide alpha Rattus norvegicus 125-129 14729435-1 2004 Previous investigations have demonstrated that delayed preconditioning induced by nitroglycerin is mediated by endogenous calcitonin gene-related peptide (CGRP). Nitroglycerin 82-95 calcitonin-related polypeptide alpha Rattus norvegicus 122-153 14729435-1 2004 Previous investigations have demonstrated that delayed preconditioning induced by nitroglycerin is mediated by endogenous calcitonin gene-related peptide (CGRP). Nitroglycerin 82-95 calcitonin-related polypeptide alpha Rattus norvegicus 155-159 14729435-2 2004 In the present study, we examined whether CGRP-mediated delayed preconditioning induced by nitroglycerin is involved in activation of inducible nitric oxide synthase (iNOS). Nitroglycerin 91-104 calcitonin-related polypeptide alpha Rattus norvegicus 42-46 14729435-7 2004 Nitroglycerin caused a significant increase in the expression of alpha-CGRP mRNA, but not beta-CGRP mRNA, concomitant with an increase in plasma concentrations of cGMP and CGRP. Nitroglycerin 0-13 calcitonin-related polypeptide alpha Rattus norvegicus 71-75 14729435-11 2004 The present results suggest that delayed cardioprotection afforded by nitroglycerin is mediated by the alpha-CGRP isoform via generation of NO derived from iNOS. Nitroglycerin 70-83 calcitonin-related polypeptide alpha Rattus norvegicus 109-113 18695513-0 2008 Nitroglycerin facilitates calcitonin gene-related peptide-induced behavior. Nitroglycerin 0-13 calcitonin-related polypeptide alpha Rattus norvegicus 26-57 18695513-2 2008 The aim of this study was to test whether systemic administration of nitroglycerin (NTG) influences the CGRP-induced behavior in awake rats and whether sumatriptan, a 5-HT1B/1D receptor agonist, can block the effects of NTG. Nitroglycerin 69-82 calcitonin-related polypeptide alpha Rattus norvegicus 104-108 18695513-2 2008 The aim of this study was to test whether systemic administration of nitroglycerin (NTG) influences the CGRP-induced behavior in awake rats and whether sumatriptan, a 5-HT1B/1D receptor agonist, can block the effects of NTG. Nitroglycerin 84-87 calcitonin-related polypeptide alpha Rattus norvegicus 104-108 17804099-1 2008 Previous studies have shown that the development of tolerance to nitroglycerin is related to reduction of endogenous calcitonin gene-related peptide (CGRP) release. Nitroglycerin 65-78 calcitonin-related polypeptide alpha Rattus norvegicus 117-148 17804099-1 2008 Previous studies have shown that the development of tolerance to nitroglycerin is related to reduction of endogenous calcitonin gene-related peptide (CGRP) release. Nitroglycerin 65-78 calcitonin-related polypeptide alpha Rattus norvegicus 150-154 17804099-2 2008 In the present study, Nitroglycerin caused a concentration-dependent relaxation concomitantly with a significant increase in the release of CGRP in the isolated rat thoracic aorta, an effect that was reduced by preincubation with capsaicin. Nitroglycerin 22-35 calcitonin-related polypeptide alpha Rattus norvegicus 140-144 17804099-3 2008 Pretreatment with nitroglycerin significantly decreased its vasodilation and depressor effect and the release of CGRP, which was restored in the presence of vinpocetine, an inhibitor of phosphodiesterase. Nitroglycerin 18-31 calcitonin-related polypeptide alpha Rattus norvegicus 113-117 17804099-4 2008 The present results suggest that reversal of tolerance to nitroglycerin with vinpocetine is related to the increased release of CGRP in the rat. Nitroglycerin 58-71 calcitonin-related polypeptide alpha Rattus norvegicus 128-132 15689199-0 2005 CGRP release and c-fos expression within trigeminal nucleus caudalis of the rat following glyceryltrinitrate infusion. Nitroglycerin 90-108 calcitonin-related polypeptide alpha Rattus norvegicus 0-4 12789484-11 2003 Since NO donors such as nitroglycerin are known to provoke headache and CGRP is released during migraine pain, the NO-stimulated CGRP release may be relevant for the development of vascular headaches that are accompanied by meningeal hyperaemia. Nitroglycerin 24-37 calcitonin-related polypeptide alpha Rattus norvegicus 129-133 12081660-0 2002 Effect of systemic nitroglycerin on CGRP and 5-HT afferents to rat caudal spinal trigeminal nucleus and its modulation by estrogen. Nitroglycerin 19-32 calcitonin-related polypeptide alpha Rattus norvegicus 36-40 12081660-4 2002 We studied the effect of nitroglycerin on the innervated area of calcitonin gene-related peptide (CGRP) and serotonin-immunoreactive afferents to the superficial laminae of the spinal portion of trigeminal nucleus caudalis, and its modulation by estrogen. Nitroglycerin 25-38 calcitonin-related polypeptide alpha Rattus norvegicus 65-96 12081660-5 2002 In male rats, nitroglycerin produced after 4 h a significant decrease of the area innervated by CGRP-immunoreactive afferents and an increase of that covered by serotonin-immunoreactive fibres. Nitroglycerin 14-27 calcitonin-related polypeptide alpha Rattus norvegicus 96-100 11521755-0 2001 The depressor effect of nitroglycerin is mediated by calcitonin gene-related peptide. Nitroglycerin 24-37 calcitonin-related polypeptide alpha Rattus norvegicus 53-84 11937102-1 2002 Previous studies have shown that the development of tolerance to nitroglycerin is related to a decrease in the release of endogenous calcitonin gene-related peptide (CGRP). Nitroglycerin 65-78 calcitonin-related polypeptide alpha Rattus norvegicus 133-164 11744139-7 2001 Nitroglycerin significantly increased plasma concentrations of CGRP and NO. Nitroglycerin 0-13 calcitonin-related polypeptide alpha Rattus norvegicus 63-67 11744139-8 2001 After pretreatment with capsaicin, which depletes neurotransmitters in sensory nerves, or methylene blue, a selective guanylate cyclase inhibitor, the protection and the elevated release of CGRP induced by nitroglycerin were abolished. Nitroglycerin 206-219 calcitonin-related polypeptide alpha Rattus norvegicus 190-194 11744139-9 2001 The present study suggests that improvement of preservation with cardioplegic solution by nitroglycerin-induced delayed preconditioning is due to stimulation of CGRP release in the rat heart, and that the protection of CGRP-mediated nitroglycerin is related to inhibition of TNF-alpha production. Nitroglycerin 90-103 calcitonin-related polypeptide alpha Rattus norvegicus 161-165 11744139-9 2001 The present study suggests that improvement of preservation with cardioplegic solution by nitroglycerin-induced delayed preconditioning is due to stimulation of CGRP release in the rat heart, and that the protection of CGRP-mediated nitroglycerin is related to inhibition of TNF-alpha production. Nitroglycerin 90-103 calcitonin-related polypeptide alpha Rattus norvegicus 219-223 11744139-9 2001 The present study suggests that improvement of preservation with cardioplegic solution by nitroglycerin-induced delayed preconditioning is due to stimulation of CGRP release in the rat heart, and that the protection of CGRP-mediated nitroglycerin is related to inhibition of TNF-alpha production. Nitroglycerin 233-246 calcitonin-related polypeptide alpha Rattus norvegicus 219-223 11557266-0 2001 Involvement of calcitonin gene-related peptide in the development of tolerance to nitroglycerin in the rat. Nitroglycerin 82-95 calcitonin-related polypeptide alpha Rattus norvegicus 15-46 11557266-1 2001 Previous studies have shown that the depressor effect of nitroglycerin is related to stimulation of endogenous calcitonin gene-related peptide (CGRP) release. Nitroglycerin 57-70 calcitonin-related polypeptide alpha Rattus norvegicus 111-142 11557266-1 2001 Previous studies have shown that the depressor effect of nitroglycerin is related to stimulation of endogenous calcitonin gene-related peptide (CGRP) release. Nitroglycerin 57-70 calcitonin-related polypeptide alpha Rattus norvegicus 144-148 11557266-2 2001 In the present study, we explored whether endogenous CGRP is involved in the development of tolerance to nitroglycerin in the rat. Nitroglycerin 105-118 calcitonin-related polypeptide alpha Rattus norvegicus 53-57 11557266-6 2001 significantly decreased blood pressure concomitantly with an increase in plasma concentration of nitric oxide (NO) and CGRP, and these effects of nitroglycerin disappeared after pretreatment with nitroglycerin for 8 days. Nitroglycerin 196-209 calcitonin-related polypeptide alpha Rattus norvegicus 119-123 11557266-7 2001 However, the nitroglycerin-induced depressor effect and elevation of NO and CGRP content were restored, partially or completely, 4 or 8 days after nitroglycerin removal in the tolerant rat. Nitroglycerin 13-26 calcitonin-related polypeptide alpha Rattus norvegicus 76-80 11557266-8 2001 The present study suggests that the development of tolerance to nitroglycerin is related to the decreased release of CGRP in the rat. Nitroglycerin 64-77 calcitonin-related polypeptide alpha Rattus norvegicus 117-121 11919648-0 2002 Delayed cardioprotection induced by nitroglycerin is mediated by alpha-calcitonin gene-related peptide. Nitroglycerin 36-49 calcitonin-related polypeptide alpha Rattus norvegicus 71-102 11919648-1 2002 Previous investigations have demonstrated that early preconditioning induced by nitroglycerin is mediated by calcitonin gene-related peptide (CGRP). Nitroglycerin 80-93 calcitonin-related polypeptide alpha Rattus norvegicus 109-140 11919648-1 2002 Previous investigations have demonstrated that early preconditioning induced by nitroglycerin is mediated by calcitonin gene-related peptide (CGRP). Nitroglycerin 80-93 calcitonin-related polypeptide alpha Rattus norvegicus 142-146 11919648-2 2002 In the present study, we addressed the question of whether delayed preconditioning induced by nitroglycerin in the rat is related to stimulation of the release and synthesis of CGRP. Nitroglycerin 94-107 calcitonin-related polypeptide alpha Rattus norvegicus 177-181 11919648-11 2002 The present results suggest that the delayed cardioprotection induced by nitroglycerin is mediated mainly by the alpha-CGRP isoform via the NO-cGMP pathway. Nitroglycerin 73-86 calcitonin-related polypeptide alpha Rattus norvegicus 119-123 11937102-1 2002 Previous studies have shown that the development of tolerance to nitroglycerin is related to a decrease in the release of endogenous calcitonin gene-related peptide (CGRP). Nitroglycerin 65-78 calcitonin-related polypeptide alpha Rattus norvegicus 166-170 11937102-2 2002 In the present study, we explored whether endogenous CGRP is involved in reversal of tolerance to nitroglycerin with N-acetylcysteine or captopril in rats in vivo and vitro. Nitroglycerin 98-111 calcitonin-related polypeptide alpha Rattus norvegicus 53-57 11937102-4 2002 Nitroglycerin (3 x 10(-9)-10(-6) M) caused a concentration-dependent relaxation in the isolated rat thoracic aorta, an effect that was reduced by CGRP-(8-37) (3 x 10(-7) M) or capsaicin (3 x 10(-7) M). Nitroglycerin 0-13 calcitonin-related polypeptide alpha Rattus norvegicus 146-150 11937102-9 2002 The present results suggest that reversal of tolerance to nitroglycerin with N-acetylcysteine or captopril is related to the increased release of CGRP in the rat. Nitroglycerin 58-71 calcitonin-related polypeptide alpha Rattus norvegicus 146-150 11711050-0 2001 Protective effects of nitroglycerin-induced preconditioning mediated by calcitonin gene-related peptide in rat small intestine. Nitroglycerin 22-35 calcitonin-related polypeptide alpha Rattus norvegicus 72-103 11711050-1 2001 Previous studies of myocardium have shown that ischemic preconditioning could be mimicked by nitroglycerin through stimulating the release of calcitonin gene-related peptide (CGRP). Nitroglycerin 93-106 calcitonin-related polypeptide alpha Rattus norvegicus 142-173 11711050-1 2001 Previous studies of myocardium have shown that ischemic preconditioning could be mimicked by nitroglycerin through stimulating the release of calcitonin gene-related peptide (CGRP). Nitroglycerin 93-106 calcitonin-related polypeptide alpha Rattus norvegicus 175-179 11711050-6 2001 However, the protection afforded by nitroglycerin was abolished by CGRP-(8-37), a selective CGRP acceptor antagonist. Nitroglycerin 36-49 calcitonin-related polypeptide alpha Rattus norvegicus 67-71 11711050-6 2001 However, the protection afforded by nitroglycerin was abolished by CGRP-(8-37), a selective CGRP acceptor antagonist. Nitroglycerin 36-49 calcitonin-related polypeptide alpha Rattus norvegicus 92-96 11711050-8 2001 In addition, the content of CGRP-like immunoreactivity in the effluent was increased during nitroglycerin perfusion. Nitroglycerin 92-105 calcitonin-related polypeptide alpha Rattus norvegicus 28-32 11711050-11 2001 All these findings suggest that nitroglycerin-induced preconditioning is related to stimulation of CGRP release in the rat small intestine. Nitroglycerin 32-45 calcitonin-related polypeptide alpha Rattus norvegicus 99-103 11521755-1 2001 Previous investigations have suggested that vasodilator responses to nitroglycerin involve in stimulation of calcitonin gene-related peptide (CGRP) release. Nitroglycerin 69-82 calcitonin-related polypeptide alpha Rattus norvegicus 109-140 11521755-1 2001 Previous investigations have suggested that vasodilator responses to nitroglycerin involve in stimulation of calcitonin gene-related peptide (CGRP) release. Nitroglycerin 69-82 calcitonin-related polypeptide alpha Rattus norvegicus 142-146 11521755-5 2001 Nitroglycerin (30 or 150 microg/kg) caused a depressor effect with an increase in plasma concentrations of CGRP. Nitroglycerin 0-13 calcitonin-related polypeptide alpha Rattus norvegicus 107-111 11521755-7 2001 The present study suggests that the depressor effect of nitroglycerin is related to stimulation of CGRP release in the rat. Nitroglycerin 56-69 calcitonin-related polypeptide alpha Rattus norvegicus 99-103 11741519-0 2001 Involvement of calcitonin gene-related peptide in nitroglycerin induced improvement of preservation with cardioplegic solution. Nitroglycerin 50-63 calcitonin-related polypeptide alpha Rattus norvegicus 15-46 11408036-1 2001 The delayed preconditioning of the heart by monophosphoryl lipid A is mediated by endogenous nitric oxide (NO), and the cardioprotection afforded by nitroglycerin is related to stimulation of calcitonin gene-related peptide (CGRP) release. Nitroglycerin 149-162 calcitonin-related polypeptide alpha Rattus norvegicus 192-223 11408036-1 2001 The delayed preconditioning of the heart by monophosphoryl lipid A is mediated by endogenous nitric oxide (NO), and the cardioprotection afforded by nitroglycerin is related to stimulation of calcitonin gene-related peptide (CGRP) release. Nitroglycerin 149-162 calcitonin-related polypeptide alpha Rattus norvegicus 225-229 11741519-1 2001 AIM: To study improvement of preservation with cardioplegic solution induced by nitroglycerin was related to stimulation of calcitonin gene-related peptide (CG RP) release. Nitroglycerin 80-93 calcitonin-related polypeptide alpha Rattus norvegicus 124-155 11741519-1 2001 AIM: To study improvement of preservation with cardioplegic solution induced by nitroglycerin was related to stimulation of calcitonin gene-related peptide (CG RP) release. Nitroglycerin 80-93 calcitonin-related polypeptide alpha Rattus norvegicus 157-162 11741519-5 2001 The protection induced by nitroglycerin was abolished by CGRP(8-37), the selective CGRP receptor antagonist, or pretreatment wit h capsaicin to deplete sensory nerves neurotransmitter content, but was unaltered by treatment w ith glibenclamide, the blocker of the ATP-sensitive potassium channel (KATP). Nitroglycerin 26-39 calcitonin-related polypeptide alpha Rattus norvegicus 57-61 11741519-5 2001 The protection induced by nitroglycerin was abolished by CGRP(8-37), the selective CGRP receptor antagonist, or pretreatment wit h capsaicin to deplete sensory nerves neurotransmitter content, but was unaltered by treatment w ith glibenclamide, the blocker of the ATP-sensitive potassium channel (KATP). Nitroglycerin 26-39 calcitonin-related polypeptide alpha Rattus norvegicus 83-87 11741519-7 2001 Levels of CGRP-LI in the coronary effluent were significantly increased in the hearts treated with nitroglycerin. Nitroglycerin 99-112 calcitonin-related polypeptide alpha Rattus norvegicus 10-14 11741519-8 2001 However, the elevated level of CGRP-LI by nitroglycerin was abolished by pretreatment with capsaicin. Nitroglycerin 42-55 calcitonin-related polypeptide alpha Rattus norvegicus 31-35 11741519-9 2001 CONCLUSION: The improvement of preservation with cardioplegic solution induced by nitroglycerin was related to stimulation of CGRP release in the rat heart, and the effect is not related to the activation of the KATP channel. Nitroglycerin 82-95 calcitonin-related polypeptide alpha Rattus norvegicus 126-130 10799659-4 2000 CGRP(8-37) (0.63 microM) induced rightward shifts in the vasodilatory concentration-response curves for nitroglycerin (NTG), Piloty"s acid (PA), and SIN-1 (linsidomine). Nitroglycerin 104-117 calcitonin-related polypeptide alpha Rattus norvegicus 0-4 10799659-6 2000 The release of CGRP from rat aorta in response to NTG and PA was measured specifically by radioimmunoassay. Nitroglycerin 50-53 calcitonin-related polypeptide alpha Rattus norvegicus 15-19 10799659-7 2000 Thirty-minute incubations of NTG or PA with rat aorta induced 189.5 and 214.6% increases, respectively, in CGRP release when compared with the control (P < 0.05). Nitroglycerin 29-32 calcitonin-related polypeptide alpha Rattus norvegicus 107-111 10799659-10 2000 These results indicate that only NTG and PA, and to a lesser extent SIN-1, stimulate the release of CGRP from the rat aorta, which subsequently contributes to the vasodilatory activity of these agents. Nitroglycerin 33-36 calcitonin-related polypeptide alpha Rattus norvegicus 100-104 10799659-4 2000 CGRP(8-37) (0.63 microM) induced rightward shifts in the vasodilatory concentration-response curves for nitroglycerin (NTG), Piloty"s acid (PA), and SIN-1 (linsidomine). Nitroglycerin 119-122 calcitonin-related polypeptide alpha Rattus norvegicus 0-4 10206178-0 1999 The cardioprotective effects of nitroglycerin-induced preconditioning are mediated by calcitonin gene-related peptide. Nitroglycerin 32-45 calcitonin-related polypeptide alpha Rattus norvegicus 86-117 10206178-1 1999 Previous investigations have shown that endogenous calcitonin gene-related peptide (CGRP) may play an important role in the mediation of ischemic preconditioning and that nitroglycerin evokes the release of CGRP. Nitroglycerin 171-184 calcitonin-related polypeptide alpha Rattus norvegicus 207-211 10206178-5 1999 The content of CGRP-like immunoreactivity in coronary effluent was increased during nitroglycerin perfusion. Nitroglycerin 84-97 calcitonin-related polypeptide alpha Rattus norvegicus 15-19 10206178-6 1999 However, the cardioprotection afforded by nitroglycerin was abolished by CGRP-(8-37) (10(-7) M), a selective CGRP receptor antagonist. Nitroglycerin 42-55 calcitonin-related polypeptide alpha Rattus norvegicus 73-77 10206178-6 1999 However, the cardioprotection afforded by nitroglycerin was abolished by CGRP-(8-37) (10(-7) M), a selective CGRP receptor antagonist. Nitroglycerin 42-55 calcitonin-related polypeptide alpha Rattus norvegicus 109-113 10206178-7 1999 Pretreatment with capsaicin (50 mg/kg, s.c.), which specifically depletes the transmitter content of sensory nerves, also abolished the protective effects of nitroglycerin and markedly reduced the release of CGRP from the heart during nitroglycerin perfusion. Nitroglycerin 235-248 calcitonin-related polypeptide alpha Rattus norvegicus 208-212 9351518-0 1997 Nitroglycerin-inhibited whole blood aggregation is partially mediated by calcitonin gene-related peptide -- a neurogenic mechanism. Nitroglycerin 0-13 calcitonin-related polypeptide alpha Rattus norvegicus 73-104 9351518-2 1997 The role of the vasculature and calcitonin gene-related peptide (CGRP) in nitroglycerin (NTG)-mediated platelet inhibition was studied. Nitroglycerin 74-87 calcitonin-related polypeptide alpha Rattus norvegicus 65-69 9351518-14 1997 Furthermore, NTG apparently evokes the release of CGRP from vascular tissue and this neuropeptide contributes to the antiplatelet actions of NTG. Nitroglycerin 13-16 calcitonin-related polypeptide alpha Rattus norvegicus 50-54 9351518-14 1997 Furthermore, NTG apparently evokes the release of CGRP from vascular tissue and this neuropeptide contributes to the antiplatelet actions of NTG. Nitroglycerin 141-144 calcitonin-related polypeptide alpha Rattus norvegicus 50-54 34979902-2 2022 Although the NF-kappaB pathway is involved in an increase in CGRP levels and activation of the trigeminal system in the NTG model, the relationship between NTG and neuroinflammation remains unclear. Nitroglycerin 120-123 calcitonin-related polypeptide alpha Rattus norvegicus 61-65 8170522-7 1994 Nitroglycerin also potentiated rCGRP-induced vasorelaxations in endothelium-denuded rings, thus uncovering a direct (endothelium-independent) relaxant effect of rCGRP in rat aorta. Nitroglycerin 0-13 calcitonin-related polypeptide alpha Rattus norvegicus 31-36 8170522-9 1994 This nitroglycerin-induced potentiation of CGRP effects likely involves inhibition of cyclic-GMP-inhibited-phosphodiesterase in smooth muscle cells, thus allowing cyclic AMP to accumulate and mediate the direct vasodilator effects of rCGRP. Nitroglycerin 5-18 calcitonin-related polypeptide alpha Rattus norvegicus 43-47 8170522-9 1994 This nitroglycerin-induced potentiation of CGRP effects likely involves inhibition of cyclic-GMP-inhibited-phosphodiesterase in smooth muscle cells, thus allowing cyclic AMP to accumulate and mediate the direct vasodilator effects of rCGRP. Nitroglycerin 5-18 calcitonin-related polypeptide alpha Rattus norvegicus 234-239 8170522-0 1994 Nitroglycerin (exogenous nitric oxide) substitutes for endothelium-derived nitric oxide in potentiating vasorelaxations and cyclic AMP elevations induced by calcitonin gene-related peptide (CGRP) in rat aorta. Nitroglycerin 0-13 calcitonin-related polypeptide alpha Rattus norvegicus 157-188 8170522-0 1994 Nitroglycerin (exogenous nitric oxide) substitutes for endothelium-derived nitric oxide in potentiating vasorelaxations and cyclic AMP elevations induced by calcitonin gene-related peptide (CGRP) in rat aorta. Nitroglycerin 0-13 calcitonin-related polypeptide alpha Rattus norvegicus 190-194 33713748-0 2021 Insulin-Like Growth Factor-1 Inhibits Nitroglycerin-Induced Trigeminal Activation of Oxidative Stress, Calcitonin Gene-Related Peptide and c-Fos Expression. Nitroglycerin 38-51 calcitonin-related polypeptide alpha Rattus norvegicus 103-134 33713748-9 2021 Measurements taken two hours later after nitroglycerin alone showed increased surrogate markers of trigeminal activation - oxidative stress and CGRP in the trigeminal ganglion and c-Fos in the trigeminocervical complex compared to vehicle control. Nitroglycerin 41-54 calcitonin-related polypeptide alpha Rattus norvegicus 144-148