PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24824125-1 2014 OBJECTIVE: To study the role of tumor necrosis factor-alpha (TNFalpha) in the anti-replication effects of tetracycline (Tet) on hepatitis B virus (HBV). tet 120-123 tumor necrosis factor Homo sapiens 61-69 27880838-4 2016 To overcome this problem, we developed a TNF-alpha expression test (TET) using primary human monocyte-derived macrophages incubated in the presence or absence of the endotoxin inhibitor, polymyxin B sulfate, and found that this assay, performed with non-cytotoxic doses of the GBM samples, enabled unequivocal detection of endotoxin with a sensitivity that is comparable to the LAL assay. tet 68-71 tumor necrosis factor Homo sapiens 41-50 24824125-6 2014 TNFalpha expression from the vector was induced by exposure to various concentrations of Tet and measured by enzyme-linked immunosorbent assay to determine the appropriate Tet concentration for experimentation. tet 89-92 tumor necrosis factor Homo sapiens 0-8 24824125-6 2014 TNFalpha expression from the vector was induced by exposure to various concentrations of Tet and measured by enzyme-linked immunosorbent assay to determine the appropriate Tet concentration for experimentation. tet 172-175 tumor necrosis factor Homo sapiens 0-8 24824125-7 2014 To investigate whether Tet inhibits TNFalpha expression as a mechanism of its anti-replication activity against HBV, the HepG2.2.15 cell line stably transfected with pVITRO3-TOTR-TNFalpha was used as an HBV replication model. tet 23-26 tumor necrosis factor Homo sapiens 36-44 24824125-10 2014 RESULTS: The TNFalpha expression from the newly constructed pVITRO3-TOTR-TNFalpha vector was Tet-controllable in the eukaryotic cells examined. tet 93-96 tumor necrosis factor Homo sapiens 13-21 24824125-10 2014 RESULTS: The TNFalpha expression from the newly constructed pVITRO3-TOTR-TNFalpha vector was Tet-controllable in the eukaryotic cells examined. tet 93-96 tumor necrosis factor Homo sapiens 73-81 24824125-17 2014 CONCLUSION: A Tet-dependent regulatory fragment double-expressing TNFalpha single vector system was constructed successfully, achieving controllable TNFalpha expression in both transiently transfected eukaryotic cells and stable cell lines. tet 14-17 tumor necrosis factor Homo sapiens 66-74 24824125-17 2014 CONCLUSION: A Tet-dependent regulatory fragment double-expressing TNFalpha single vector system was constructed successfully, achieving controllable TNFalpha expression in both transiently transfected eukaryotic cells and stable cell lines. tet 14-17 tumor necrosis factor Homo sapiens 149-157 24824125-18 2014 In this HBV cell model system, Tet-induced overexpression of human TNFalpha inhibited HBV DNA replication and reduced HBsAg and HBeAg expression. tet 31-34 tumor necrosis factor Homo sapiens 67-75 18498042-4 2008 We found that TET decreased the release of NO, TNF-alpha, IL-6 and IL-1beta in LPS-activated astrocytes. tet 14-17 tumor necrosis factor Homo sapiens 47-56 30824537-5 2019 In contrast, prolonged TNFalpha treatment (several days) induced DNA demethylation at the promoter and a CpG island in the IL-32 gene in a TET (ten-eleven translocation) family enzyme- and NF-kappaB-dependent manner. tet 139-142 tumor necrosis factor Homo sapiens 23-31 30428756-7 2018 Furthermore, co-incubation with Tet significantly down-regulated HaCaT cell production of tumour necrosis factor (TNF)-alpha, IL-1beta, IL-6, IL-20 and chemokine (C-C motif) ligand 20 (CCL20) induced by IL-22. tet 32-35 tumor necrosis factor Homo sapiens 90-124