PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21862836-9	2011	The results also suggest a new potential mechanism for active DNA demethylation, involving TDG excision of Tet-produced fC (or caC) and subsequent BER.	tet	107-110	thymine DNA glycosylase	Homo sapiens	91-94	
33561435-7	2021	We show that collaborative TET-TDG oxidation-excision activity is only marginally reduced for CA versus CG contexts.	tet	27-30	thymine DNA glycosylase	Homo sapiens	31-34	
27580719-3	2016	Essential for DNA demethylation, TDG excises 5-formylcytosine and 5-carboxylcytosine, derivatives of mC generated by Tet (ten-eleven translocation) enzymes.	tet	117-120	thymine DNA glycosylase	Homo sapiens	33-36	
27805810-2	2016	Performing a critical step in a pathway for active DNA demethylation, TDG removes 5-formylcytosine and 5-carboxylcytosine, oxidized derivatives of 5-methylcytosine that are generated by TET (ten-eleven translocation) enzymes.	tet	186-189	thymine DNA glycosylase	Homo sapiens	70-73	
26932196-4	2016	Here we show that TET1 and TDG physically interact to oxidize and excise 5mC, and proof by biochemical reconstitution that the TET-TDG-BER system is capable of productive DNA demethylation.	tet	18-21	thymine DNA glycosylase	Homo sapiens	131-134	
26358812-3	2015	In DNA demethylation, TDG excises 5-formylcytosine (fC) and 5-carboxylcytosine (caC), which are generated from mC by Tet (ten-eleven translocation) enzymes.	tet	117-120	thymine DNA glycosylase	Homo sapiens	22-25	
25845601-3	2015	Here, we demonstrate that Gadd45a promotes active DNA demethylation through thymine DNA glycosylase (TDG) which has recently been shown to excise 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) generated in Ten-eleven-translocation (Tet)-initiated oxidative demethylation.	tet	238-241	thymine DNA glycosylase	Homo sapiens	76-99	
25845601-3	2015	Here, we demonstrate that Gadd45a promotes active DNA demethylation through thymine DNA glycosylase (TDG) which has recently been shown to excise 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) generated in Ten-eleven-translocation (Tet)-initiated oxidative demethylation.	tet	238-241	thymine DNA glycosylase	Homo sapiens	101-104	
26932196-3	2016	This implicated a pathway operating through oxidation of 5mC by TET proteins, which generates substrates for TDG-dependent base excision repair (BER) that then replaces 5mC with C. Yet, direct evidence for a productive coupling of TET with BER has never been presented.	tet	64-67	thymine DNA glycosylase	Homo sapiens	109-112	
26932196-3	2016	This implicated a pathway operating through oxidation of 5mC by TET proteins, which generates substrates for TDG-dependent base excision repair (BER) that then replaces 5mC with C. Yet, direct evidence for a productive coupling of TET with BER has never been presented.	tet	231-234	thymine DNA glycosylase	Homo sapiens	109-112	
21817016-0	2011	Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.	tet	0-3	thymine DNA glycosylase	Homo sapiens	65-68	
21817016-6	2011	These data suggest that oxidation of 5mC by Tet proteins followed by TDG-mediated base excision of 5caC constitutes a pathway for active DNA demethylation.	tet	44-47	thymine DNA glycosylase	Homo sapiens	69-72	
34567494-6	2021	The TET-TDG-BER pathway could cause the production of DNA strand breaks and therefore jeopardize the integrity of genomes.	tet	4-7	thymine DNA glycosylase	Homo sapiens	8-11	
34567494-8	2021	Our results clearly demonstrated the decarboxylation of 5caC occurring in mammalian genomes, which unveiled that, in addition to the TET-TDG-BER pathway, the direct decarboxylation of TET-produced 5caC constituted a new pathway for active demethylation of 5mC in mammalian genomes.	tet	133-136	thymine DNA glycosylase	Homo sapiens	137-140