PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33694104-4 2021 In humans, there are three TET paralogs with tissue-specific expression, namely TET1, TET2, and TET3. tet 27-30 tet methylcytosine dioxygenase 2 Homo sapiens 86-90 35586434-4 2022 Recently, a novel cytosine-based inhibitor of TET, Bobcat339, was reported to have mid-muM inhibitory activity against TET1 and TET2. tet 46-49 tet methylcytosine dioxygenase 2 Homo sapiens 128-132 35494033-11 2022 Therefore, we explored the patterns of TET transcripts in plasma samples and we found that their profiles were variously regulated, with significant value for TET2. tet 39-42 tet methylcytosine dioxygenase 2 Homo sapiens 159-163 31033072-5 2019 Among the three TET genes, TET1 and TET2 expression levels have frequently been shown to be low in hepatocellular carcinoma (HCC) tissues and received most attention. tet 16-19 tet methylcytosine dioxygenase 2 Homo sapiens 36-40 29483655-2 2018 Unlike the other members of the TET family, TET2 does not contain a DNA-binding domain, and it remains unclear how it is recruited to chromatin. tet 32-35 tet methylcytosine dioxygenase 2 Homo sapiens 44-48 31055566-3 2019 The TET family includes three members: TET1, TET2, and TET3. tet 4-7 tet methylcytosine dioxygenase 2 Homo sapiens 45-49 25510268-4 2015 Among the three TET genes, TET2 recurrently undergoes inactivating mutations in a wide range of myeloid and lymphoid malignancies. tet 16-19 tet methylcytosine dioxygenase 2 Homo sapiens 27-31 29175454-7 2018 To gain an understanding into how iAs might impact TET expression, we found that iAs inhibits the binding of CTCF at the proximal, weak CTCF binding sites of the TET1 and TET2 gene promoters and enhances CTCF binding at the stronger distal binding site. tet 51-54 tet methylcytosine dioxygenase 2 Homo sapiens 171-175 29048538-5 2017 We also discovered that TET expression was enhanced under low oxygen (5%) culture conditions, which facilitated CNS2 DNA demethylation and stabilization of Foxp3 expression in a TET2- and TET3-dependent manner. tet 24-27 tet methylcytosine dioxygenase 2 Homo sapiens 178-182 27523618-6 2016 Notably, we demonstrate that MCPIP1 reduces TET (TET1/TET2/TET3) levels and then decreases 5-hydroxymethylcytosine levels. tet 44-47 tet methylcytosine dioxygenase 2 Homo sapiens 54-58 26633372-3 2015 Three TET paralogs have been identified (TET1, TET2, and TET3) in humans. tet 6-9 tet methylcytosine dioxygenase 2 Homo sapiens 47-51 26378518-2 2015 The TET family includes TET1, TET2 and TET3 members in mammals. tet 4-7 tet methylcytosine dioxygenase 2 Homo sapiens 30-34 23222540-1 2013 Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. tet 26-29 tet methylcytosine dioxygenase 2 Homo sapiens 56-60 23730200-4 2012 These new modifications, putative intermediates in a pathway to erase DNA methylation marks, are catalyzed by the ten-eleven translocation (Tet) proteins, specifically by Tet1 and Tet2 in ES cells. tet 140-143 tet methylcytosine dioxygenase 2 Homo sapiens 180-184 21324307-4 2011 5hmC, on the other hand, has only recently entered center stage when it was shown that the Ten-Eleven-Translocation (TET) family of oxygenases catalyzes the conversion of 5mC to 5hmC, and that one of these enzymes, TET2, is frequently mutated in myeloid neoplasms. tet 117-120 tet methylcytosine dioxygenase 2 Homo sapiens 215-219