PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19230406-4 2008 The cell cycle distribution was altered and ratio of S phase and G2/M phase cell increased following the treatment with Tet combined with Nap, with Bcl-2 gene expression down-regulated, and BAX gene expression up-regulated. tet 120-123 BCL2 apoptosis regulator Homo sapiens 148-153 24989284-7 2014 After being treated with Tet alone, FQ-PCR and Western blot showed that the expressions of caspase-3 mRNA and caspase-3 protein were up-regulated, the expressions of BCL-2 mRNA and protein were down-regulated, the effect of both drug combination was more significant. tet 25-28 BCL2 apoptosis regulator Homo sapiens 166-171 24989284-9 2014 Combination of IM with Tet shows obvious synergistic effect, mechanism of which may associate with up-regulation of caspase-3 mRNA and protein expressions, and down-regulation of BCL-2 mRNA and protein expressions. tet 23-26 BCL2 apoptosis regulator Homo sapiens 179-184 22366014-1 2012 OBJECTIVE: To investigate the effect of tetrandrine (Tet) on the expression of bax, bcl-2, and transforming growth factor-beta2 (TGF-beta2) mRNA in cultured human fibroblasts of Tenon"s capsules (TCFS) and explore its possible mechanism. tet 53-56 BCL2 apoptosis regulator Homo sapiens 84-89 22366014-3 2012 RESULTS: The expression level of bax mRNA was obviously higher, while bcl-2 and TGF-beta2 mRNA levels were significantly lower in Tet-treated TCFS than those in the control cells (P<0.05). tet 130-133 BCL2 apoptosis regulator Homo sapiens 70-75 22366014-4 2012 CONCLUSION: Tet can inhibit the proliferation of TCFS possibly by reducing the expressions of bcl-2 and TGF-beta2 mRNA, enhancing the expression of bax mRNA and inducing cell apoptosis, suggesting its potential in preventing fibrous scar formation after glaucoma filtration surgery. tet 12-15 BCL2 apoptosis regulator Homo sapiens 96-101