PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24989284-7	2014	After being treated with Tet alone, FQ-PCR and Western blot showed that the expressions of caspase-3 mRNA and caspase-3 protein were up-regulated, the expressions of BCL-2 mRNA and protein were down-regulated, the effect of both drug combination was more significant.	tet	25-28	BCL2 apoptosis regulator	Homo sapiens	166-171	
24989284-9	2014	Combination of IM with Tet shows obvious synergistic effect, mechanism of which may associate with up-regulation of caspase-3 mRNA and protein expressions, and down-regulation of BCL-2 mRNA and protein expressions.	tet	23-26	BCL2 apoptosis regulator	Homo sapiens	179-184	
19230406-4	2008	The cell cycle distribution was altered and ratio of S phase and G2/M phase cell increased following the treatment with Tet combined with Nap, with Bcl-2 gene expression down-regulated, and BAX gene expression up-regulated.	tet	120-123	BCL2 apoptosis regulator	Homo sapiens	148-153	
22366014-1	2012	OBJECTIVE: To investigate the effect of tetrandrine (Tet) on the expression of bax, bcl-2, and transforming growth factor-beta2 (TGF-beta2) mRNA in cultured human fibroblasts of Tenon"s capsules (TCFS) and explore its possible mechanism.	tet	53-56	BCL2 apoptosis regulator	Homo sapiens	84-89	
22366014-3	2012	RESULTS: The expression level of bax mRNA was obviously higher, while bcl-2 and TGF-beta2 mRNA levels were significantly lower in Tet-treated TCFS than those in the control cells (P<0.05).	tet	130-133	BCL2 apoptosis regulator	Homo sapiens	70-75	
22366014-4	2012	CONCLUSION: Tet can  inhibit  the proliferation of TCFS possibly by reducing the expressions of bcl-2 and TGF-beta2 mRNA, enhancing the expression of bax mRNA and inducing cell apoptosis, suggesting its potential in preventing fibrous scar formation after glaucoma filtration surgery.	tet	12-15	BCL2 apoptosis regulator	Homo sapiens	96-101