PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22366014-1 2012 OBJECTIVE: To investigate the effect of tetrandrine (Tet) on the expression of bax, bcl-2, and transforming growth factor-beta2 (TGF-beta2) mRNA in cultured human fibroblasts of Tenon"s capsules (TCFS) and explore its possible mechanism. tet 53-56 BCL2 associated X, apoptosis regulator Homo sapiens 79-82 22366014-3 2012 RESULTS: The expression level of bax mRNA was obviously higher, while bcl-2 and TGF-beta2 mRNA levels were significantly lower in Tet-treated TCFS than those in the control cells (P<0.05). tet 130-133 BCL2 associated X, apoptosis regulator Homo sapiens 33-36 22366014-4 2012 CONCLUSION: Tet can inhibit the proliferation of TCFS possibly by reducing the expressions of bcl-2 and TGF-beta2 mRNA, enhancing the expression of bax mRNA and inducing cell apoptosis, suggesting its potential in preventing fibrous scar formation after glaucoma filtration surgery. tet 12-15 BCL2 associated X, apoptosis regulator Homo sapiens 150-153 19230406-4 2008 The cell cycle distribution was altered and ratio of S phase and G2/M phase cell increased following the treatment with Tet combined with Nap, with Bcl-2 gene expression down-regulated, and BAX gene expression up-regulated. tet 120-123 BCL2 associated X, apoptosis regulator Homo sapiens 190-193