PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20154710-9	2010	CONCLUSION: FLZ exerted neuroprotection at least partly through enhancing the BDNF/TrkB/CREB pathway and inhibiting neuronal apoptosis in APP/PS1 mice, which suggests that FLZ can be explored as a potential therapeutic agent in long-term Alzheimer"s disease therapy.	flz	172-175	cAMP responsive element binding protein 1	Mus musculus	88-92	
20154710-0	2010	The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice.	flz	34-37	cAMP responsive element binding protein 1	Mus musculus	57-61	
20154710-1	2010	AIM: The aim of this study was to study the effects of compound FLZ, a novel cyclic derivative of squamosamide from Annona glabra, on brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element-binding protein (CREB) signaling and neuronal apoptosis in the hippocampus of the amyloid precursor protein (APP)/presenilin-1 (PS1) double transgenic mice.	flz	64-67	cAMP responsive element binding protein 1	Mus musculus	251-255	
20154710-7	2010	In addition, FLZ promoted BDNF high-affinity receptor TrkB phosphorylation and activated its downstream ERK, thus increasing phosphorylation of CREB at Ser133 in the hippocampus of APP/PS1 mice.	flz	13-16	cAMP responsive element binding protein 1	Mus musculus	144-148	
20154710-9	2010	CONCLUSION: FLZ exerted neuroprotection at least partly through enhancing the BDNF/TrkB/CREB pathway and inhibiting neuronal apoptosis in APP/PS1 mice, which suggests that FLZ can be explored as a potential therapeutic agent in long-term Alzheimer"s disease therapy.	flz	12-15	cAMP responsive element binding protein 1	Mus musculus	88-92