PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33721755-1 2021 The enzyme 5-lipoxygenase (5-LO) converts arachidonic acid to leukotrienes, which mediate inflammation. Leukotrienes 62-74 arachidonate 5-lipoxygenase Mus musculus 11-25 2844191-5 1988 L-651,896 (2,3-dihydro-6-[3-(2-hydroxymethyl)phenyl-2-propenyl]-5-benzofuranol), a 5-lipoxygenase inhibitor, reduced leukotriene levels but did not reduce swelling or prostaglandin levels. Leukotrienes 117-128 arachidonate 5-lipoxygenase Mus musculus 83-97 3099336-1 1986 In order to identify regulatory steps in leukotriene synthesis, the biochemical characteristics of a 5-lipoxygenase activity in the 100,000 xg supernatant from sonicates of cells of an IL-3 dependent murine mast cell clone, MC-9 were determined. Leukotrienes 41-52 arachidonate 5-lipoxygenase Mus musculus 101-115 3099336-12 1986 These results show that the 5-lipoxygenase requires hydroperoxide for activation and that cellular level of hydroperoxides may be an important factor regulating leukotriene synthesis. Leukotrienes 161-172 arachidonate 5-lipoxygenase Mus musculus 28-42 6318834-3 1984 The specific inhibitors for 5-lipoxygenase would be useful not only as tools for investigating the regulation mechanism of leukotriene biosynthesis, but also as drugs for clinical use. Leukotrienes 123-134 arachidonate 5-lipoxygenase Mus musculus 28-42 6318834-5 1984 We found that caffeic acid, which is one of the most common reagents, is a selective inhibitor for 5-lipoxygenase and therefore for leukotriene biosynthesis. Leukotrienes 132-143 arachidonate 5-lipoxygenase Mus musculus 99-113 33721755-1 2021 The enzyme 5-lipoxygenase (5-LO) converts arachidonic acid to leukotrienes, which mediate inflammation. Leukotrienes 62-74 arachidonate 5-lipoxygenase Mus musculus 27-31 33721755-4 2021 Mechanistically, the exogenous leukotrienes B4 and C4, the downstream products of 5-LO, could induce the epithelial-mesenchymal transition (EMT) in kidney epithelial cell cultures, based on assays of E-cadherin, vimentin and snail expression. Leukotrienes 31-43 arachidonate 5-lipoxygenase Mus musculus 82-86 31300449-4 2019 The functions of leukotriene in tumor cell proliferation and tumor growth in medulloblastoma were determined through knocking down 5-lipoxygenase (a critical enzyme for leukotriene synthesis) by shRNAs, or using 5-lipoxygenase-deficient mice. Leukotrienes 17-28 arachidonate 5-lipoxygenase Mus musculus 131-145 33484341-1 2021 5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is an arachidonic acid metabolite produced along with leukotrienes via the 5-lipoxygenase pathway. Leukotrienes 104-116 arachidonate 5-lipoxygenase Mus musculus 125-139 33679410-2 2021 5-lipoxygenase (5-LO) is the key enzyme that catalyzes arachidonic acid into leukotrienes. Leukotrienes 77-89 arachidonate 5-lipoxygenase Mus musculus 0-14 31642348-3 2020 In vitro mutagenesis of the triad determinants abolished the leukotriene synthesizing activity of ALOX5 but the biological consequences of these alterations have not been studied. Leukotrienes 61-72 arachidonate 5-lipoxygenase Mus musculus 98-103 30649890-1 2019 In inflammatory diseases, the 5-lipoxygenase (5-LO) pathway contributes to epithelial damage and fibrosis by catalyzing the production of leukotrienes (LTs). Leukotrienes 138-150 arachidonate 5-lipoxygenase Mus musculus 30-44 31167124-2 2019 5-Lipoxygenase (5-LO) is the key enzyme involved in synthesis of leukotrienes (LTs). Leukotrienes 65-77 arachidonate 5-lipoxygenase Mus musculus 0-14 31167124-2 2019 5-Lipoxygenase (5-LO) is the key enzyme involved in synthesis of leukotrienes (LTs). Leukotrienes 79-82 arachidonate 5-lipoxygenase Mus musculus 0-14 30649890-1 2019 In inflammatory diseases, the 5-lipoxygenase (5-LO) pathway contributes to epithelial damage and fibrosis by catalyzing the production of leukotrienes (LTs). Leukotrienes 152-155 arachidonate 5-lipoxygenase Mus musculus 30-44 30122897-1 2018 Background: Biosynthesis of leukotriene (LT) by arachidonic acid involves 5-lipoxygenase (5-LO) as an important precursor. Leukotrienes 28-39 arachidonate 5-lipoxygenase Mus musculus 74-88 28737505-1 2017 Proinflammatory leukotrienes (LTs) are produced by 5-lipoxygenase (5-LO) aided by 5-LO-activating protein (FLAP). Leukotrienes 16-28 arachidonate 5-lipoxygenase Mus musculus 51-65 29607621-1 2018 The 5-lipoxygenase (5LO) is a source of inflammatory leukotrienes and is upregulated in Alzheimer"s disease and related tauopathies. Leukotrienes 53-65 arachidonate 5-lipoxygenase Mus musculus 4-18 29311656-7 2018 Within the endothelial population, cells that transition from haemogenic endothelial to erythro-myeloid progenitors specifically express Alox5 and its co-factor Alox5ap, which control leukotriene production. Leukotrienes 184-195 arachidonate 5-lipoxygenase Mus musculus 137-142 28623130-4 2017 In an experimental mouse CML model system, the leukotriene pathway, and specifically, the expression ALOX5, encoding 5-lipoxygenase (5-LO), has been reported as a critical regulator of the LSC. Leukotrienes 47-58 arachidonate 5-lipoxygenase Mus musculus 101-106 28623130-4 2017 In an experimental mouse CML model system, the leukotriene pathway, and specifically, the expression ALOX5, encoding 5-lipoxygenase (5-LO), has been reported as a critical regulator of the LSC. Leukotrienes 47-58 arachidonate 5-lipoxygenase Mus musculus 117-131 28737505-1 2017 Proinflammatory leukotrienes (LTs) are produced by 5-lipoxygenase (5-LO) aided by 5-LO-activating protein (FLAP). Leukotrienes 30-33 arachidonate 5-lipoxygenase Mus musculus 51-65 28894350-3 2017 Leukotrienes (LTs), lipid mediators produced from 5-lipoxygenase (5-LO) enzyme, increase FcgammaR-mediated phagocytosis. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 50-64 28894350-3 2017 Leukotrienes (LTs), lipid mediators produced from 5-lipoxygenase (5-LO) enzyme, increase FcgammaR-mediated phagocytosis. Leukotrienes 14-17 arachidonate 5-lipoxygenase Mus musculus 50-64 27530926-1 2016 5-Lipoxygenase (5-LOX) is an enzyme that converts arachidonic acid from the cell membrane into leukotriene, a signal lipid mediator. Leukotrienes 95-106 arachidonate 5-lipoxygenase Mus musculus 0-14 27530926-1 2016 5-Lipoxygenase (5-LOX) is an enzyme that converts arachidonic acid from the cell membrane into leukotriene, a signal lipid mediator. Leukotrienes 95-106 arachidonate 5-lipoxygenase Mus musculus 16-21 27262746-6 2016 Leukotrienes are lipid mediators derived from arachidonic acid metabolites via 5-lipoxygenase (5LO) enzyme. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 79-93 26649828-8 2015 Genetic or pharmacological inhibition of the leukotriene-generating enzyme arachidonate 5-lipoxygenase (Alox5) abrogates neutrophil pro-metastatic activity and consequently reduces metastasis. Leukotrienes 45-56 arachidonate 5-lipoxygenase Mus musculus 75-102 26690703-8 2016 In an SCD mouse model, we observed increased AHR and higher leukotriene levels that were abrogated by anti-PlGF Ab or the 5-lipoxygenase inhibitor zileuton. Leukotrienes 60-71 arachidonate 5-lipoxygenase Mus musculus 122-136 26663781-1 2016 Eicosanoids, including PGs, produced by cyclooxygenases (COX), and leukotrienes, produced by 5-lipoxygenase (5-LO) have been implicated in cancer progression. Leukotrienes 67-79 arachidonate 5-lipoxygenase Mus musculus 93-107 27198524-2 2016 In addition, some evidence suggests that inflammatory mediators such as leukotrienes (LTs), which include the 5-lipoxygenase (LOX) family, can regulate endothelial cell differentiation. Leukotrienes 72-84 arachidonate 5-lipoxygenase Mus musculus 110-124 27198524-2 2016 In addition, some evidence suggests that inflammatory mediators such as leukotrienes (LTs), which include the 5-lipoxygenase (LOX) family, can regulate endothelial cell differentiation. Leukotrienes 72-84 arachidonate 5-lipoxygenase Mus musculus 126-129 27198524-2 2016 In addition, some evidence suggests that inflammatory mediators such as leukotrienes (LTs), which include the 5-lipoxygenase (LOX) family, can regulate endothelial cell differentiation. Leukotrienes 86-89 arachidonate 5-lipoxygenase Mus musculus 110-124 27198524-2 2016 In addition, some evidence suggests that inflammatory mediators such as leukotrienes (LTs), which include the 5-lipoxygenase (LOX) family, can regulate endothelial cell differentiation. Leukotrienes 86-89 arachidonate 5-lipoxygenase Mus musculus 126-129 26649828-8 2015 Genetic or pharmacological inhibition of the leukotriene-generating enzyme arachidonate 5-lipoxygenase (Alox5) abrogates neutrophil pro-metastatic activity and consequently reduces metastasis. Leukotrienes 45-56 arachidonate 5-lipoxygenase Mus musculus 104-109 26432605-1 2015 5-Lipoxygenase synthesizes leukotrienes from arachidonic acid. Leukotrienes 27-39 arachidonate 5-lipoxygenase Mus musculus 0-14 25747113-4 2015 The levels of 5-lipoxygenase (5-LO), the key enzyme for leukotrienes production, are increased in colon cancer specimens and colonic dysplastic lesions. Leukotrienes 56-68 arachidonate 5-lipoxygenase Mus musculus 14-28 25583526-4 2015 5-Lipoxygenase (5-LO) is an enzyme required for the production of the lipid mediators leukotrienes and lipoxins. Leukotrienes 86-98 arachidonate 5-lipoxygenase Mus musculus 16-20 26265153-3 2015 The 5-lipoxygenase (5-LOX) is a key enzyme in the biosynthesis of the leukotrienes and has been implicated and in the central nervous system (CNS) disorders such as Alzheimer"s disease and acute ischemic stroke. Leukotrienes 70-82 arachidonate 5-lipoxygenase Mus musculus 4-18 26265153-3 2015 The 5-lipoxygenase (5-LOX) is a key enzyme in the biosynthesis of the leukotrienes and has been implicated and in the central nervous system (CNS) disorders such as Alzheimer"s disease and acute ischemic stroke. Leukotrienes 70-82 arachidonate 5-lipoxygenase Mus musculus 20-25 25324573-1 2014 OBJECTIVE: The impact of leukotriene production by the 5-lipoxygenase (5-LO) pathway in the pathophysiology of abdominal aortic aneurysms (AAAs) has been debated. Leukotrienes 25-36 arachidonate 5-lipoxygenase Mus musculus 55-69 24892983-1 2014 Leukotrienes (LTs) are 5-lipoxygenase (5-LO) metabolites which are implicated in sex-dependent inflammatory diseases (asthma, autoimmune diseases, etc.). Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 23-37 24892983-1 2014 Leukotrienes (LTs) are 5-lipoxygenase (5-LO) metabolites which are implicated in sex-dependent inflammatory diseases (asthma, autoimmune diseases, etc.). Leukotrienes 14-17 arachidonate 5-lipoxygenase Mus musculus 23-37 25032067-2 2014 Cyclooxygenase-1 and cyclooxygenase-2 mediate the production of prostanoids, whereas 5-lipoxygenase mediates the production of leukotrienes and hydroxyeicosatetraenoic acids. Leukotrienes 127-139 arachidonate 5-lipoxygenase Mus musculus 85-99 25025775-0 2014 5-Lipoxygenase activating protein (FLAP) dependent leukotriene biosynthesis inhibition (MK591) attenuates Lipid A endotoxin-induced inflammation. Leukotrienes 51-62 arachidonate 5-lipoxygenase Mus musculus 0-14 25025775-11 2014 Together, these data clarify the mechanistic association between 5-lipoxygenase activating protein-mediated leukotriene biosynthesis and 5-LO dependent eicosanoid metabolites in mediating the TLR-dependent inflammatory response after endotoxin exposure typical of bacterial sepsis. Leukotrienes 108-119 arachidonate 5-lipoxygenase Mus musculus 65-79 24795811-3 2014 Cyclooxygenase (COX-1 or COX-2) and 5-lipoxygenase (5-LO) catalyze the initial enzymatic steps in the synthesis of prostaglandins and leukotrienes, respectively. Leukotrienes 134-146 arachidonate 5-lipoxygenase Mus musculus 36-50 23947598-2 2014 Leukotrienes (LTs) are important lipid mediators of infection and inflammation derived from the 5-lipoxygenase (5-LO) metabolism of arachidonate with the potential to contribute to lung damage after sepsis. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 96-110 23947598-2 2014 Leukotrienes (LTs) are important lipid mediators of infection and inflammation derived from the 5-lipoxygenase (5-LO) metabolism of arachidonate with the potential to contribute to lung damage after sepsis. Leukotrienes 14-17 arachidonate 5-lipoxygenase Mus musculus 96-110 23800665-2 2013 5-Lipoxygenase (5-LOX) is the enzyme responsible for catalysing the synthesis of leukotriene or 5-HETE from arachidonic acid. Leukotrienes 81-92 arachidonate 5-lipoxygenase Mus musculus 0-14 23859654-1 2013 Leukotrienes (i.e., products of the 5-lipoxygenase pathway) are thought to be contributors to lung pathologies. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 36-50 23800665-2 2013 5-Lipoxygenase (5-LOX) is the enzyme responsible for catalysing the synthesis of leukotriene or 5-HETE from arachidonic acid. Leukotrienes 81-92 arachidonate 5-lipoxygenase Mus musculus 16-21 23991239-1 2013 Leukotrienes (LTs) produced from arachidonic acid by the action of 5-lipoxygenase (5-LO) are classical mediators of inflammatory responses. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 67-81 23991239-1 2013 Leukotrienes (LTs) produced from arachidonic acid by the action of 5-lipoxygenase (5-LO) are classical mediators of inflammatory responses. Leukotrienes 14-17 arachidonate 5-lipoxygenase Mus musculus 67-81 23954958-1 2013 BACKGROUND/AIMS: The unique role of enzyme 5-lipoxygenase (5-LO) in the production of leukotrienes makes it a therapeutic target for inflammatory bowel disease (IBD). Leukotrienes 86-98 arachidonate 5-lipoxygenase Mus musculus 43-57 23812248-3 2013 The enzyme 5-lipoxygenase (5-LOX) has a key role in the transformation of arachidonic acid in leukotrienes. Leukotrienes 94-106 arachidonate 5-lipoxygenase Mus musculus 11-25 23812248-3 2013 The enzyme 5-lipoxygenase (5-LOX) has a key role in the transformation of arachidonic acid in leukotrienes. Leukotrienes 94-106 arachidonate 5-lipoxygenase Mus musculus 27-32 23246375-1 2013 5-Lipoxygenase (ALOX5) is a key enzyme in biosynthesis of pro-inflammatory leukotrienes whereas 15-lipoxygenases (ALOX15) have been implicated in the formation of pro-resolving eicosanoids (lipoxins, resolvins). Leukotrienes 75-87 arachidonate 5-lipoxygenase Mus musculus 0-14 23357209-1 2013 The 5-lipoxygenase is an enzyme widely expressed in the central nervous system, where its activity is dependent on the presence the 5-lipoxygenase activating protein (FLAP) for the formation of leukotrienes, potent bioactive lipid mediators. Leukotrienes 194-206 arachidonate 5-lipoxygenase Mus musculus 4-18 23357209-1 2013 The 5-lipoxygenase is an enzyme widely expressed in the central nervous system, where its activity is dependent on the presence the 5-lipoxygenase activating protein (FLAP) for the formation of leukotrienes, potent bioactive lipid mediators. Leukotrienes 194-206 arachidonate 5-lipoxygenase Mus musculus 132-146 23246375-1 2013 5-Lipoxygenase (ALOX5) is a key enzyme in biosynthesis of pro-inflammatory leukotrienes whereas 15-lipoxygenases (ALOX15) have been implicated in the formation of pro-resolving eicosanoids (lipoxins, resolvins). Leukotrienes 75-87 arachidonate 5-lipoxygenase Mus musculus 16-21 21755457-2 2012 Metabolites of the arachidonic acid derived from the 5-lipoxygenase pathway are known as leukotrienes that mediate various inflammatory processes during atherogenesis. Leukotrienes 89-101 arachidonate 5-lipoxygenase Mus musculus 53-67 23109727-1 2012 5-Lipoxygenase (5-LO) catalyzes the formation of two major groups of leukotrienes, leukotriene B4 and cysteinyl leukotrienes (CysLTs), and it has been implicated as a promising drug target to treat various inflammatory diseases. Leukotrienes 69-81 arachidonate 5-lipoxygenase Mus musculus 0-14 22128029-1 2012 5-Lipoxygenase catalyzes leukotriene generation from arachidonic acid. Leukotrienes 25-36 arachidonate 5-lipoxygenase Mus musculus 0-14 24288682-1 2013 5-Lipoxygenase (5-LO) converts arachidonic acid into leukotrienes (LTs) and is involved in inflammation. Leukotrienes 53-65 arachidonate 5-lipoxygenase Mus musculus 0-14 24288682-1 2013 5-Lipoxygenase (5-LO) converts arachidonic acid into leukotrienes (LTs) and is involved in inflammation. Leukotrienes 67-70 arachidonate 5-lipoxygenase Mus musculus 0-14 22688342-6 2012 Mice that are deficient for the enzyme 5-lipoxygenase (5-LO), and therefore lack LTs, exhibit a decrease in HFD-induced AT macrophage and T-cell infiltration and are partially protected from HFD-induced insulin resistance. Leukotrienes 81-84 arachidonate 5-lipoxygenase Mus musculus 39-53 20851170-7 2010 We propose that Purkinje cell-localized 5-LOX and FLAP expression may be involved in the cerebellar synthesis of leukotrienes and/or could influence the Dicer-mediated microRNA formation and processes of neuroplasticity. Leukotrienes 113-125 arachidonate 5-lipoxygenase Mus musculus 40-45 21506958-1 2011 BACKGROUND AND PURPOSE: 5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of pro-inflammatory leukotrienes (LTs) representing a potential target for pharmacological intervention with inflammation and allergic disorders. Leukotrienes 104-116 arachidonate 5-lipoxygenase Mus musculus 24-38 21506958-1 2011 BACKGROUND AND PURPOSE: 5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of pro-inflammatory leukotrienes (LTs) representing a potential target for pharmacological intervention with inflammation and allergic disorders. Leukotrienes 118-121 arachidonate 5-lipoxygenase Mus musculus 24-38 21270404-1 2011 The enzyme 5-lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid into the leukotrienes, which are critical regulators of inflammation and inflammatory diseases, such as asthma and arthritis. Leukotrienes 87-99 arachidonate 5-lipoxygenase Mus musculus 11-25 21067431-3 2010 Arachidonic acid is also converted into leukotrienes by 5-lipoxygenase (5-LO). Leukotrienes 40-52 arachidonate 5-lipoxygenase Mus musculus 56-70 20173212-3 2010 5-Lipoxygenase (5-LOX)-derived leukotrienes were significantly elevated in all the areas of white matter in the cALD brain. Leukotrienes 31-43 arachidonate 5-lipoxygenase Mus musculus 0-14 20381637-3 2010 T. cruzi infection in mice deficient in 5-lipoxygenase (5-LO), the enzyme responsible for the synthesis of LTs and other lipid inflammatory mediators, resulted in transiently increased parasitemia, and improved survival rate compared with WT mice. Leukotrienes 107-110 arachidonate 5-lipoxygenase Mus musculus 40-54 20173212-3 2010 5-Lipoxygenase (5-LOX)-derived leukotrienes were significantly elevated in all the areas of white matter in the cALD brain. Leukotrienes 31-43 arachidonate 5-lipoxygenase Mus musculus 16-21 19834040-6 2010 RESULTS: Bone marrow cells from nondiabetic mice expressed 5-lipoxygenase, the enzyme required for the initiation of leukotriene synthesis, and produced leukotriene B(4) (LTB(4)) when stimulated with the calcium ionophore A23187. Leukotrienes 117-128 arachidonate 5-lipoxygenase Mus musculus 59-73 19965960-1 2010 AIMS: It is well established that leukotrienes (LTs), products of the 5-lipoxygenase (5-LO) pathway, participate in inflammatory tissue reactions and immune responses. Leukotrienes 34-46 arachidonate 5-lipoxygenase Mus musculus 70-84 19965960-1 2010 AIMS: It is well established that leukotrienes (LTs), products of the 5-lipoxygenase (5-LO) pathway, participate in inflammatory tissue reactions and immune responses. Leukotrienes 48-51 arachidonate 5-lipoxygenase Mus musculus 70-84 18804760-0 2009 Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice. Leukotrienes 61-72 arachidonate 5-lipoxygenase Mus musculus 46-60 20091263-4 2009 (-)-Nyasol also inhibited 5-lipoxygenase (5-LOX)-mediated leukotriene production in A23187-treated RBL-1 cells. Leukotrienes 58-69 arachidonate 5-lipoxygenase Mus musculus 26-40 20091263-4 2009 (-)-Nyasol also inhibited 5-lipoxygenase (5-LOX)-mediated leukotriene production in A23187-treated RBL-1 cells. Leukotrienes 58-69 arachidonate 5-lipoxygenase Mus musculus 42-47 19573621-7 2009 By directly immuno-localizing leukotrienes at their sites of synthesis, we showed that oxLDL-induced newly formed lipid bodies function as active sites of LTB(4) and LTC(4) synthesis, since oxLDL-induced lipid bodies within foam macrophages compartmentalized the enzyme 5-lipoxygenase and five lipoxygenase-activating protein (FLAP) as well as newly formed LTB(4) and LTC(4). Leukotrienes 30-42 arachidonate 5-lipoxygenase Mus musculus 270-284 18804760-1 2009 The 5-lipoxygenase (5-LO) catalyzed formation of leukotriene (LT) lipid mediators is a pathway contributing to inflammatory events in asthma and more recently has been associated with cardiovascular disease. Leukotrienes 49-60 arachidonate 5-lipoxygenase Mus musculus 4-18 17392829-0 2007 Selective 5-lipoxygenase expression in Langerhans cells and impaired dendritic cell migration in 5-LO-deficient mice reveal leukotriene action in skin. Leukotrienes 124-135 arachidonate 5-lipoxygenase Mus musculus 10-24 19776641-7 2009 The 5-lipoxygenase (5-LO)/leukotriene (LT) biosynthesis pathway has been biochemically and genetically associated with CVD traits in mice and humans, particularly in the context of dietary AA and EPA/DHA. Leukotrienes 26-37 arachidonate 5-lipoxygenase Mus musculus 4-18 18004232-1 2008 Leukotrienes (LTs), metabolites of arachidonic acid through 5-lipoxygenase (5-LOX), have been known to play a role in leukocyte recruitment. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 60-74 18004232-1 2008 Leukotrienes (LTs), metabolites of arachidonic acid through 5-lipoxygenase (5-LOX), have been known to play a role in leukocyte recruitment. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 76-81 18004232-1 2008 Leukotrienes (LTs), metabolites of arachidonic acid through 5-lipoxygenase (5-LOX), have been known to play a role in leukocyte recruitment. Leukotrienes 14-17 arachidonate 5-lipoxygenase Mus musculus 60-74 18004232-1 2008 Leukotrienes (LTs), metabolites of arachidonic acid through 5-lipoxygenase (5-LOX), have been known to play a role in leukocyte recruitment. Leukotrienes 14-17 arachidonate 5-lipoxygenase Mus musculus 76-81 18059327-1 2008 BACKGROUND AND PURPOSE: 5-lipoxygenase (5-LO) is the key enzyme in leukotriene (LT) biosynthesis from arachidonic acid (AA). Leukotrienes 67-78 arachidonate 5-lipoxygenase Mus musculus 24-38 17998412-1 2008 5-Lipoxygenase (5LO), by producing leukotrienes, is a proinflammatory enzyme, and there is evidence suggesting that it is up-regulated with aging and may be involved in Alzheimer"s disease (AD). Leukotrienes 35-47 arachidonate 5-lipoxygenase Mus musculus 0-14 18336255-3 2008 Studies have found that increased IgE levels, eosinophilia, positive skin-prick tests, self-reported asthma and enzymes that regulate leukotriene synthesis (5-lipoxygenase) predict a high risk for atherosclerosis, stroke and myocardial infarction. Leukotrienes 134-145 arachidonate 5-lipoxygenase Mus musculus 157-171 18048478-1 2008 Leukotrienes are potent lipid mediators derived from the metabolism of arachidonic acid by the enzyme 5-lipoxygenase (5-LO). Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 102-116 17586489-4 2007 Therefore, we tested the effect of ischemia reperfusion in mice with targeted deletion of 5-lipoxygenase, the enzyme converting arachidonic acid in leukotrienes. Leukotrienes 148-160 arachidonate 5-lipoxygenase Mus musculus 90-104 17392829-1 2007 5-Lipoxygenase (5-LO) catalyzes the initial steps in the formation of leukotrienes (LTs), which are implicated in immune reactions. Leukotrienes 70-82 arachidonate 5-lipoxygenase Mus musculus 0-14 17392829-1 2007 5-Lipoxygenase (5-LO) catalyzes the initial steps in the formation of leukotrienes (LTs), which are implicated in immune reactions. Leukotrienes 84-87 arachidonate 5-lipoxygenase Mus musculus 0-14 17334599-1 2007 The leukotrienes (LTs) are metabolic products of arachidonic acid via the 5-lipoxygenase (5-LO) pathway. Leukotrienes 4-16 arachidonate 5-lipoxygenase Mus musculus 74-88 17397875-1 2007 Leukotrienes are lipid mediators of inflammation derived from the 5-lipoxygenase pathway of arachidonic acid metabolism, and recent evidence suggests that they play an important role in pulmonary fibrosis. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 66-80 17347013-1 2007 Leukotrienes produced from arachidonic acid by the action of 5-lipoxygenase (5-LO) are classical mediators of inflammatory responses. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 61-75 17334599-1 2007 The leukotrienes (LTs) are metabolic products of arachidonic acid via the 5-lipoxygenase (5-LO) pathway. Leukotrienes 18-21 arachidonate 5-lipoxygenase Mus musculus 74-88 16506957-2 2006 Leukotrienes are produced by 5-lipoxygenase co-operating with five lipoxygenase activating protein (FLAP). Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 29-43 16624488-6 2006 Administration of TQ before OVA challenge inhibited 5-lipoxygenase, the main enzyme in leukotriene biosynthesis, expression by lung cells and significantly reduced the levels of LTB4 and LTC4. Leukotrienes 87-98 arachidonate 5-lipoxygenase Mus musculus 52-66 16489117-9 2006 This hyperresponsiveness was inhibited by 5-lipoxygenase inhibitor and IL-13 neutralization, suggesting that airway responses were induced through IL-13 and leukotriene pathway. Leukotrienes 157-168 arachidonate 5-lipoxygenase Mus musculus 42-56 17182931-1 2006 Activation of the 5-lipoxygenase (5-LO) pathway leads to the biosynthesis of proinflammatory leukotriene (LT) lipid mediators in macrophages, mast cells, and other inflammatory cell types. Leukotrienes 93-104 arachidonate 5-lipoxygenase Mus musculus 18-32 20477620-2 2006 The 5-LO pathway plays a fundamental role in the biosynthesis of leukotrienes, essential inflammatory lipid mediators. Leukotrienes 65-77 arachidonate 5-lipoxygenase Mus musculus 4-8 20477620-6 2006 Human genetic studies as well as disruption of the 5-LO gene in mouse models of hyperlipidemia revealed that 5-LO and 5-LO-activating protein are associated with risks of human cardiovascular disease, and that this cascade plays an important role in aortic aneurysm pathogenesis through leukotriene-mediated inflammatory chemokine production. Leukotrienes 287-298 arachidonate 5-lipoxygenase Mus musculus 109-113 20477620-6 2006 Human genetic studies as well as disruption of the 5-LO gene in mouse models of hyperlipidemia revealed that 5-LO and 5-LO-activating protein are associated with risks of human cardiovascular disease, and that this cascade plays an important role in aortic aneurysm pathogenesis through leukotriene-mediated inflammatory chemokine production. Leukotrienes 287-298 arachidonate 5-lipoxygenase Mus musculus 109-113 15821759-2 2005 The unique role of the enzyme 5-lipoxygenase (5-LO) in the production of leukotrienes makes it as therapeutic target for inflammatory conditions like inflammatory bowel disease (IBD). Leukotrienes 73-85 arachidonate 5-lipoxygenase Mus musculus 30-44 15894604-3 2005 Recent experimental studies have revealed an important role for leukotriene (LT) biosynthesis by 5-lipoxygenase (5LO) in the impairment of HPV by endotoxin. Leukotrienes 64-75 arachidonate 5-lipoxygenase Mus musculus 97-111 16046553-1 2005 Leukotrienes (LT) and prostaglandins (PG) are proinflammatory mediators generated by the conversion of arachidonic acid via 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 124-138 16081317-1 2005 Leukotrienes (LTs) are powerful inflammatory lipid mediators derived from the 5-lipoxygenase (5-LO) cascade of arachidonic acid. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 78-92 16081317-1 2005 Leukotrienes (LTs) are powerful inflammatory lipid mediators derived from the 5-lipoxygenase (5-LO) cascade of arachidonic acid. Leukotrienes 14-17 arachidonate 5-lipoxygenase Mus musculus 78-92 11518028-4 2001 All above-mentioned furocoumarins showed significant effect on 5-lipoxygenase (leukotriene C4) with IC50 values of < 15 microM. Leukotrienes 79-90 arachidonate 5-lipoxygenase Mus musculus 63-77 15353362-4 2004 We have demonstrated that leukotrienes (LTs; 5-LOX-derived eicosanoids) and various isomers of epoxyeicosatrienoic acids (EETs; epoxygenase-derived eicosanoids) contribute to the process of endogenous antipyresis or cryogenesis, which limits the height of fever. Leukotrienes 26-38 arachidonate 5-lipoxygenase Mus musculus 45-50 15322539-1 2004 Activation of the 5-lipoxygenase (5-LO) pathway leads to the biosynthesis of proinflammatory leukotriene lipid mediators. Leukotrienes 93-104 arachidonate 5-lipoxygenase Mus musculus 18-32 11919084-1 2002 5-lipoxygenase (ALOX5), an enzyme essential for the formation of all leukotrienes, is highly regulated at multiple levels, including gene transcription. Leukotrienes 69-81 arachidonate 5-lipoxygenase Mus musculus 0-14 11919084-1 2002 5-lipoxygenase (ALOX5), an enzyme essential for the formation of all leukotrienes, is highly regulated at multiple levels, including gene transcription. Leukotrienes 69-81 arachidonate 5-lipoxygenase Mus musculus 16-21 12237493-1 2002 PURPOSE: 5-Lipoxygenase (5LOX) is an enzyme critical for leukotriene synthesis from arachidonic acid. Leukotrienes 57-68 arachidonate 5-lipoxygenase Mus musculus 9-23 12237493-1 2002 PURPOSE: 5-Lipoxygenase (5LOX) is an enzyme critical for leukotriene synthesis from arachidonic acid. Leukotrienes 57-68 arachidonate 5-lipoxygenase Mus musculus 25-29 11714834-2 2001 LTs, the products of the 5-lipoxygenase (5-LO) pathway, are potent lipid mediators with a broad range of biologic activities. Leukotrienes 0-3 arachidonate 5-lipoxygenase Mus musculus 25-39 15661924-1 2005 The 5-lipoxygenase (5-LO)-derived leukotrienes (LTs) influence both local innate immunity and vascular responses, but the relative importance of effects on these two processes in sepsis is unknown. Leukotrienes 34-46 arachidonate 5-lipoxygenase Mus musculus 4-18 15661924-1 2005 The 5-lipoxygenase (5-LO)-derived leukotrienes (LTs) influence both local innate immunity and vascular responses, but the relative importance of effects on these two processes in sepsis is unknown. Leukotrienes 48-51 arachidonate 5-lipoxygenase Mus musculus 4-18 15361791-10 2004 Novel data have also shown that many types of cells in lesions express 5-lipoxygenase, which indicates a rich source of leukotrienes in plaque. Leukotrienes 120-132 arachidonate 5-lipoxygenase Mus musculus 71-85 15328042-3 2004 In contrast, 5-lipoxygenase (5-LO) produces the generally proinflammatory leukotrienes (LTs) which would be expected to worsen EAE. Leukotrienes 74-86 arachidonate 5-lipoxygenase Mus musculus 13-27 15328042-3 2004 In contrast, 5-lipoxygenase (5-LO) produces the generally proinflammatory leukotrienes (LTs) which would be expected to worsen EAE. Leukotrienes 88-91 arachidonate 5-lipoxygenase Mus musculus 13-27 15223810-2 2004 Cyclooxygenase (COX)-2 is an enzyme that initiates the conversion of arachidonic acid (AA) into prostaglandins (PGs), whereas 5-lipoxygenase (5-LO) generates leukotrienes (LT). Leukotrienes 158-170 arachidonate 5-lipoxygenase Mus musculus 126-140 12730086-2 2003 An athero-resistance gene cluster has been localized at the central region of chromosome 6, and among the candidate genes of this locus, the 5-lipoxygenase has attracted particular attention because of its involvement in the biosynthesis of proinflammatory leukotrienes. Leukotrienes 257-269 arachidonate 5-lipoxygenase Mus musculus 141-155 12142344-2 2002 5-Lipoxygenase (5-LO) is the rate-limiting enzyme in leukotriene synthesis and was among the chromosome 6 locus candidate genes that we examined. Leukotrienes 53-64 arachidonate 5-lipoxygenase Mus musculus 0-14 12021253-2 2002 The production of leukotrienes is tightly regulated, and expression of 5-lipoxygenase, the enzyme required for the first step in leukotriene synthesis, is generally restricted to leukocytes. Leukotrienes 18-29 arachidonate 5-lipoxygenase Mus musculus 71-85 11451994-4 2001 An initial transient arachidonate release occurs during cell attachment to fibronectin, and is sufficient to signal the cell spreading stage after its oxidation by 5-lipoxygenase to leukotrienes. Leukotrienes 182-194 arachidonate 5-lipoxygenase Mus musculus 164-178 11160610-1 2001 The metabolism of arachidonic acid by the 5-lipoxygenase pathway not only leads to the formation of leukotrienes but also to the biologically active eicosanoid 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE). Leukotrienes 100-112 arachidonate 5-lipoxygenase Mus musculus 42-56 11254552-4 2001 Inhibition of endogenous leukotriene synthesis by 5-lipoxygenase knockout in mice or by pharmacologic means in human peripheral blood neutrophils attenuated phagocytosis of opsonized K. pneumoniae. Leukotrienes 25-36 arachidonate 5-lipoxygenase Mus musculus 50-64 10779800-1 2000 Leukotrienes (LT) are potent lipid mediators synthesized by the 5-lipoxygenase pathway of arachidonic acid (AA) metabolism. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 64-78 11082424-2 2000 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. Leukotrienes 167-178 arachidonate 5-lipoxygenase Mus musculus 68-82 10514459-1 1999 5-Lipoxygenase catalyzes the synthesis of leukotrienes from arachidonic acid. Leukotrienes 42-54 arachidonate 5-lipoxygenase Mus musculus 0-14 10586081-1 1999 Arachidonic acid metabolism by 5-lipoxygenase leads to production of the potent inflammatory mediators, leukotriene (LT) B4 and the cysteinyl LT. Leukotrienes 104-115 arachidonate 5-lipoxygenase Mus musculus 31-45 10514459-8 1999 As nuclear import of 5-lipoxygenase may regulate leukotriene production, natural or induced mutations in this bipartite nuclear localization sequence may also be important in affecting leukotriene synthesis. Leukotrienes 49-60 arachidonate 5-lipoxygenase Mus musculus 21-35 10514459-8 1999 As nuclear import of 5-lipoxygenase may regulate leukotriene production, natural or induced mutations in this bipartite nuclear localization sequence may also be important in affecting leukotriene synthesis. Leukotrienes 185-196 arachidonate 5-lipoxygenase Mus musculus 21-35 10384136-1 1999 Leukotrienes, the 5-lipoxygenase (5LO) products of arachidonic acid metabolism, have many proinflammatory actions that have been implicated in the pathogenesis of a variety of inflammatory diseases. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 18-32 9091580-2 1997 The synthesis of these lipids is believed to be dependent not only on the expression of the enzyme 5-lipoxygenase (5-LO), which catalyzes the first steps in the synthesis of leukotrienes, but also on expression of a nuclear membrane protein termed the 5-LO-activating protein (FLAP). Leukotrienes 174-186 arachidonate 5-lipoxygenase Mus musculus 99-113 9744535-1 1998 5-Lipoxygenase is a key enzyme in the metabolism of arachidonic acid to leukotrienes. Leukotrienes 72-84 arachidonate 5-lipoxygenase Mus musculus 0-14 8915769-3 1996 Here, we show the effects of the third metabolic product of the 5-lipoxygenase (5-LO) pathway of arachidonic acid metabolism, the leukotriene LTB4, on osteoclastic bone resorption both in vivo and in vitro. Leukotrienes 130-141 arachidonate 5-lipoxygenase Mus musculus 64-78 7969451-0 1994 Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Leukotrienes 8-20 arachidonate 5-lipoxygenase Mus musculus 60-74 7510095-8 1993 5-Lipoxygenase metabolites, the leukotrienes, stimulate isolated osteoclasts to form resorption pits as well as cause osteoclastic bone resorption in organ cultures of neonatal mouse calvariae. Leukotrienes 32-44 arachidonate 5-lipoxygenase Mus musculus 0-14 1880419-8 1991 The 5-lipoxygenase inhibitor A-63162 blocked leukotriene production in a dose-dependent manner in both sets of mice. Leukotrienes 45-56 arachidonate 5-lipoxygenase Mus musculus 4-18 1825502-11 1991 Collectively these data suggest that the leukotriene products of the 5"-lipoxygenase pathway, LTC4 and LTB4, regulate the expression of lysosomal enzymes by apparently priming macrophages, thereby increasing their sensitivity to triggering agents such as beta 1,3-glucan. Leukotrienes 41-52 arachidonate 5-lipoxygenase Mus musculus 69-84 2116176-1 1990 Mammalian 5-lipoxygenase systems exist in inactive or cryptic states and have to be stimulated in order to metabolize exogenous [14C]arachidonic acid to 5-HETE and leukotrienes. Leukotrienes 164-176 arachidonate 5-lipoxygenase Mus musculus 10-24 34896181-5 2022 Leukotrienes (LTs) are lipid mediators derived from the oxidation of arachidonic acid by 5-lipoxygenase (5-LO), and are classically involved in inflammation, allergies, and asthma. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 89-103 34896181-5 2022 Leukotrienes (LTs) are lipid mediators derived from the oxidation of arachidonic acid by 5-lipoxygenase (5-LO), and are classically involved in inflammation, allergies, and asthma. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 105-109 34896181-5 2022 Leukotrienes (LTs) are lipid mediators derived from the oxidation of arachidonic acid by 5-lipoxygenase (5-LO), and are classically involved in inflammation, allergies, and asthma. Leukotrienes 14-17 arachidonate 5-lipoxygenase Mus musculus 89-103 34896181-5 2022 Leukotrienes (LTs) are lipid mediators derived from the oxidation of arachidonic acid by 5-lipoxygenase (5-LO), and are classically involved in inflammation, allergies, and asthma. Leukotrienes 14-17 arachidonate 5-lipoxygenase Mus musculus 105-109 34677413-1 2021 Arachidonic acid 5-lipoxygenase (ALOX5) is the key enzyme in the biosynthesis of pro-inflammatory leukotrienes. Leukotrienes 98-110 arachidonate 5-lipoxygenase Mus musculus 33-38 34677413-7 2021 These results were somewhat surprising since in previous loss-of-function studies targeting leukotriene biosynthesis (Alox5-/- mice, inhibitor studies), more severe inflammatory symptoms were observed in the EAE model but the degree of inflammation in DSS colitis was attenuated. Leukotrienes 92-103 arachidonate 5-lipoxygenase Mus musculus 118-123 8955165-1 1996 Leukotrienes (LTs) are potent mediators of inflammation derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Leukotrienes 0-12 arachidonate 5-lipoxygenase Mus musculus 73-87 8955165-1 1996 Leukotrienes (LTs) are potent mediators of inflammation derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Leukotrienes 14-17 arachidonate 5-lipoxygenase Mus musculus 73-87 7679445-9 1993 It is concluded that the swelling-induced activation of the taurine leak pathway involves a release of arachidonic acid from the membrane phospholipids and an increased oxidation of arachidonic acid into leukotrienes via the 5-lipoxygenase pathway. Leukotrienes 204-216 arachidonate 5-lipoxygenase Mus musculus 225-239 1419079-6 1992 The 5-lipoxygenase inhibitor A-63162 blocked the leukotriene formation. Leukotrienes 49-60 arachidonate 5-lipoxygenase Mus musculus 4-18