PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3031215-2 1987 Enzymes involved in its synthesis, arachidonate 5-lipoxygenase [arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid and subsequently to leukotriene A4] and leukotriene A4 hydrolase (leukotriene A4 to B4), were present in the cytosol fraction. Leukotrienes 163-174 arachidonate 5-lipoxygenase Cavia porcellus 35-62 3395791-2 1988 The effect of a novel series of orally-active acetohydroxamic acid inhibitors of arachidonate 5-lipoxygenase on "leukotriene-dependent" anaphylactic bronchoconstriction has been investigated in anaesthetized, pump-ventilated guinea-pigs actively sensitized to ovalbumin (OA). Leukotrienes 113-124 arachidonate 5-lipoxygenase Cavia porcellus 81-108