PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27990118-2 2016 Many studies implicate polymorphisms in genes encoding the enzymes responsible for leukotriene synthesis and intracellular signaling through activation of seven transmembrane domain receptors, such as the cysteinyl leukotriene 1 (CYSLTR1) and 2 (CYSLTR2) receptors. Leukotrienes 83-94 cysteinyl leukotriene receptor 2 Homo sapiens 246-253 25760841-7 2015 CONCLUSIONS: CysLTR-1 and CysLTR-2 are highly expressed in the adenoid tissues from children with AH, suggesting that leukotrienes are involved in the pathogenesis of AH. Leukotrienes 118-130 cysteinyl leukotriene receptor 2 Homo sapiens 26-34 19077707-7 2009 Variants in ALOX5, LTA4H, LTC4S, ABCC1, CYSLTR2, and SLCO2B1 contribute to variability in response to leukotriene modifiers. Leukotrienes 102-113 cysteinyl leukotriene receptor 2 Homo sapiens 40-47 24361619-9 2014 CONCLUSIONS: These results indicate that mAbLTC and scFvLTC neutralize the biological activities of LTs by competing their binding to CysLT1R and CysLT2R. Leukotrienes 100-103 cysteinyl leukotriene receptor 2 Homo sapiens 146-153 17460547-10 2007 CYSLTR2 and ALOX5 polymorphisms may predispose a minority of individuals to excessive cysteinyl-leukotriene concentrations, yielding a distinct asthma phenotype most likely to respond to leukotriene modifier pharmacotherapy. Leukotrienes 96-107 cysteinyl leukotriene receptor 2 Homo sapiens 0-7 17394438-1 2007 The 5-Lipoxygenase pathway results in the formation of leukotrienes, including leukotriene B(4) (LTB(4)), 5-oxo-6E,8Z,11Z,14Z-eicosatetranoic acid and the cysteinyl leukotrienes (LTC(4), LTD(4) and LTE(4)) and activates all four leukotriene receptors, BLT1, BLT2, cysLT(1) and cysLT(2). Leukotrienes 55-67 cysteinyl leukotriene receptor 2 Homo sapiens 277-285 12816882-9 2003 CONCLUSIONS: Our data raise the possibility that MPhi-derived LTs differentially activate cysLT2-Rs via paracrine stimulation and cysLT1-Rs via autocrine and paracrine stimulation during inflammation and atherogenesis. Leukotrienes 62-65 cysteinyl leukotriene receptor 2 Homo sapiens 90-96 11093801-6 2000 The leukotriene analog BAY u9773, reported to be a dual CysLT(1)/CysLT(2) antagonist, was found to be an antagonist at CysLT(1) sites but acted as a partial agonist at this new receptor. Leukotrienes 4-15 cysteinyl leukotriene receptor 2 Homo sapiens 65-73