PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10454832-14 1999 IL-1 is required for increased leukotriene and prostacyclin levels in this model, but it is not involved in thromboxane release. Leukotrienes 31-42 interleukin 1 alpha Homo sapiens 0-4 10384913-4 1999 In tape stripped skin, levels of prostaglandin E2 and interleukin-1alpha were increased 3.4-fold and 3.3-fold, respectively (p<0.0001; p<0.02), levels of tumour necrosis factor-alpha were decreased 3.0-fold (p<0.01), whereas levels of interleukin-6 and leukotriene B4 in blister fluids remained relatively unchanged. Leukotrienes 262-273 interleukin 1 alpha Homo sapiens 54-72 3532812-2 1986 Interleukin-1 (IL-1) was found to be several log times more potent in this respect than C5a des Arg, leukotriene B4, and f-Met-Leu-Phe and of comparable potency to endotoxin. Leukotrienes 101-112 interleukin 1 alpha Homo sapiens 0-13 8722494-1 1996 Prostaglandins and leukotrienes differentially regulate the production of interleukin-1 (IL-1) in monocytes. Leukotrienes 19-31 interleukin 1 alpha Homo sapiens 89-93 2357213-1 1990 The objective of this work was to investigate the role of leukotrienes in the production of IL-1 by activated human peripheral blood monocytes and mouse peritoneal macrophages. Leukotrienes 58-70 interleukin 1 alpha Homo sapiens 92-96 2841909-5 1988 Leukotriene products in addition to being pro-inflammatory per se also enhance IL-1 formation whilst cyclo-oxygenase products inhibit IL-1. Leukotrienes 0-11 interleukin 1 alpha Homo sapiens 79-83 9242341-1 1997 OBJECTIVE: The purpose of the study was to identify the changes in plasma prostaglandin, leukotriene, and cytokine levels during clinical severe sepsis for which interleukin-1 was necessary. Leukotrienes 89-100 interleukin 1 alpha Homo sapiens 162-175 11859379-9 1996 Although IL-1-induced IL-6 expression was only affected when both prostaglandin and leukotriene biosynthesis were inhibited, elevated levels of PGE(2) but not leukotriene B(4), C(4), D(4), or E(4) were observed in the culture medium of IL-1-treated chondrocytes. Leukotrienes 84-95 interleukin 1 alpha Homo sapiens 9-13 34064821-0 2021 Leukotriene B4 Receptors Are Necessary for the Stimulation of NLRP3 Inflammasome and IL-1beta Synthesis in Neutrophil-Dominant Asthmatic Airway Inflammation. Leukotrienes 0-11 interleukin 1 alpha Homo sapiens 85-93 2540636-0 1989 Leukotrienes and macrophage activation: augmented cytotoxic activity and enhanced interleukin 1, tumor necrosis factor and hydrogen peroxide production. Leukotrienes 0-12 interleukin 1 alpha Homo sapiens 82-118 2999234-9 1985 These results indicate that leukotrienes can modulate IL 1 production by human monocytes and suggest that they may play a role in IL 1-mediated functions of monocytes in inflammatory and immune reactions. Leukotrienes 28-40 interleukin 1 alpha Homo sapiens 54-58 2999234-0 1985 Leukotrienes augment interleukin 1 production by human monocytes. Leukotrienes 0-12 interleukin 1 alpha Homo sapiens 21-34 2999234-1 1985 The effects of leukotrienes (LT) on production of interleukin 1 (IL 1) by human peripheral blood monocytes were examined. Leukotrienes 15-27 interleukin 1 alpha Homo sapiens 50-69 2999234-9 1985 These results indicate that leukotrienes can modulate IL 1 production by human monocytes and suggest that they may play a role in IL 1-mediated functions of monocytes in inflammatory and immune reactions. Leukotrienes 28-40 interleukin 1 alpha Homo sapiens 130-134