PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16967052-4 2006 KEY RESULTS: Pyrrophenone potently inhibited LT, PGE2 and PAF biosynthesis in PMN with IC50s in the range of 1-20 nM. Leukotrienes 8-10 PCNA clamp associated factor Homo sapiens 58-61 18193345-4 2008 In addition, PAF administration can mimic some of abnormalities observed in asthma, including bronchoconstriction, bronchial hyper responsiveness, and gas exchange impairment, which may be mediated by leukotrienes acting as secondary mediators of some PAF effects. Leukotrienes 201-213 PCNA clamp associated factor Homo sapiens 13-16 18193345-4 2008 In addition, PAF administration can mimic some of abnormalities observed in asthma, including bronchoconstriction, bronchial hyper responsiveness, and gas exchange impairment, which may be mediated by leukotrienes acting as secondary mediators of some PAF effects. Leukotrienes 201-213 PCNA clamp associated factor Homo sapiens 252-255 16967052-1 2006 BACKGROUND AND PURPOSE: The biosynthesis of leukotrienes (LT) and platelet-activating factor (PAF) involves the release of their respective precursors, arachidonic acid (AA) and lyso-PAF by the group IVA PLA2 (cPLA2alpha). Leukotrienes 44-56 PCNA clamp associated factor Homo sapiens 183-186 16415501-3 2005 Despite the fact that PAF exerts these actions within minutes, they are mediated by other lipid mediators, in particular eicosanoids generated by cyclooxygenase and lipoxygenase enzymes and sphingolipids generated by acid sphingomyelinase.We will discuss the mechanisms of the PAF-induced pressor responses that are triggered by thromboxane A(2) and leukotrienes, as well the PAF-induced increase in vascular permeability that is mediated by prostaglandin E(2) (PGE(2)) and ceramide. Leukotrienes 350-362 PCNA clamp associated factor Homo sapiens 22-25 11175901-1 2001 Leukotriene (LT) A(4) hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc enzyme that catalyzes the biosynthesis of LTB4, a potent lipid chemoattractant involved in inflammation, immune responses, host defense against infection, and PAF-induced shock. Leukotrienes 0-11 PCNA clamp associated factor Homo sapiens 237-240 18034553-7 2000 In addition, at least part of the pulmonary effects of PAF could be related to the secondary release of leukotrienes. Leukotrienes 104-116 PCNA clamp associated factor Homo sapiens 55-58 9845549-11 1998 We hypothesize that the differential ability of PAF and fMLP to induce elastase release from surface-adherent neutrophils could arise from differential ability to generate leukotrienes, such as LTB4, and would be an appropriate mechanism for the control of elastase release during inflammation in vivo, where it is important that cytotoxic agents are not released until activated neutrophils have migrated into the extravascular tissues. Leukotrienes 172-184 PCNA clamp associated factor Homo sapiens 48-51 10886400-5 2000 PAF induced superoxide anion (O2-*) generation, leukotriene C4 (LTC4) release, intracellular calcium ion mobilization and tyrosine phosphorylation of multiple eosinophil proteins in a concentration-dependent manner. Leukotrienes 48-59 PCNA clamp associated factor Homo sapiens 0-3 10886400-8 2000 We conclude that PAF activates PTK in human eosinophils and that this signalling pathway is involved in eliciting respiratory burst and leukotriene production. Leukotrienes 136-147 PCNA clamp associated factor Homo sapiens 17-20 9648962-0 1998 Platelet-activating factor increases leukotriene B4 release in stimulated alveolar macrophages from asthmatic patients. Leukotrienes 37-48 PCNA clamp associated factor Homo sapiens 0-26 9763906-4 1998 Presence of LTs and high levels of PAF in 0" samples compared to levels in controls and significant increases in 1" samples suggested the alterations in PAF and LTs likely originated from the peripheral leukocyte activation. Leukotrienes 12-15 PCNA clamp associated factor Homo sapiens 153-156 9603138-2 1998 We investigated whether PAF-induced neutropenia and lung function disturbances are secondary to activation of the 5-lipoxygenase (5-LO) pathway with the consequent liberation of leukotrienes. Leukotrienes 178-190 PCNA clamp associated factor Homo sapiens 24-27 9603138-8 1998 These findings indicate that PAF-induced systemic and pulmonary effects in patients with mild asthma are effectively mediated by the ongoing release of leukotrienes. Leukotrienes 152-164 PCNA clamp associated factor Homo sapiens 29-32 8724598-4 1996 The intracellular function of PAF and its analogs is discussed in terms of their influence on prostaglandin and leukotriene biosynthesis as well as with reference to the biological activity of 1-acyl-2-acetyl-sn-glycerols and lysophosphatidylcholine. Leukotrienes 112-123 PCNA clamp associated factor Homo sapiens 30-33 9041476-3 1997 PAF effects are induced by direct actions of PAF on cardiac tissue to modify chronotropic and inotropic activity, or indirectly via the release of eicosanoids such as thromboxane A2 (TXA2), leukotrienes (LT) or cytokines (TNF alpha). Leukotrienes 190-202 PCNA clamp associated factor Homo sapiens 0-3 9583202-3 1998 Leukotrienes (LT) are mediators released by either leukocytes or glomerular cells under the PAF effect. Leukotrienes 0-12 PCNA clamp associated factor Homo sapiens 92-95 9583202-3 1998 Leukotrienes (LT) are mediators released by either leukocytes or glomerular cells under the PAF effect. Leukotrienes 14-16 PCNA clamp associated factor Homo sapiens 92-95 8071595-1 1994 We studied the effect of the linoleic acid metabolite 13-hydroxyoctadecadienoic acid (13-HODE) on the increase of the intracellular calcium concentration, [Ca2+]i, induced by platelet-activating factor (PAF), leukotriene B4 (LTB4), and formyl-Met-Leu-Phe (fMLP) in human polymorphonuclear leukocytes (PMNs). Leukotrienes 209-220 PCNA clamp associated factor Homo sapiens 175-201 1711077-3 1991 In this study we examined the effect of PAF upon the release of histamine and leukotriene (LT) C4 by basophils when added alone and in combination with different agonists and cytokines. Leukotrienes 78-89 PCNA clamp associated factor Homo sapiens 40-43 8019762-0 1994 Autocrine enhancement of leukotriene synthesis by endogenous leukotriene B4 and platelet-activating factor in human neutrophils. Leukotrienes 25-36 PCNA clamp associated factor Homo sapiens 80-106 1655549-13 1991 Our data also demonstrate that leukocytes and the release of leukotrienes participate in PAF priming. Leukotrienes 61-73 PCNA clamp associated factor Homo sapiens 89-92 1330924-1 1992 Platelet activating factor (PAF) is a potent lipid mediator that induces the release of leukotrienes and prostaglandins from various cells and tissues. Leukotrienes 88-100 PCNA clamp associated factor Homo sapiens 0-26 1330924-1 1992 Platelet activating factor (PAF) is a potent lipid mediator that induces the release of leukotrienes and prostaglandins from various cells and tissues. Leukotrienes 88-100 PCNA clamp associated factor Homo sapiens 28-31 1661723-0 1991 Inhaled PAF stimulates leukotriene and thromboxane A2 production in humans. Leukotrienes 23-34 PCNA clamp associated factor Homo sapiens 8-11 1657632-0 1991 Platelet-activating factor impairs mucociliary transport and increases plasma leukotriene B4 in man. Leukotrienes 78-89 PCNA clamp associated factor Homo sapiens 0-26 1846895-4 1991 Human neutrophils stimulated with PAF in the range of 10(-5) to 10(-7) M for 15 min released small quantities of leukotriene B4 and its omega-oxidation products, 20-OH- and 20-COOH-leukotriene B4 in amounts that were detectable by enzyme immunoassay. Leukotrienes 113-124 PCNA clamp associated factor Homo sapiens 34-37 1846895-11 1991 These results indicate that preincubation of peripheral blood neutrophils with GM-CSF enhances the ability of PAF to stimulate leukotriene synthesis by increasing both arachidonic acid availability and 5-lipoxygenase activation in response to PAF. Leukotrienes 127-138 PCNA clamp associated factor Homo sapiens 110-113 1846895-8 1991 In addition to its effect on PAF-induced leukotriene synthesis, GM-CSF also augmented intracellular calcium mobilization by PAF. Leukotrienes 41-52 PCNA clamp associated factor Homo sapiens 29-32 2790041-0 1989 Platelet-activating factor induces the production of leukotrienes by human monocytes. Leukotrienes 53-65 PCNA clamp associated factor Homo sapiens 0-26 2274568-0 1990 Platelet-activating factor (PAF) and its relation to prostaglandins, leukotrienes and other aspects of arachidonate metabolism. Leukotrienes 69-81 PCNA clamp associated factor Homo sapiens 0-26 2274568-0 1990 Platelet-activating factor (PAF) and its relation to prostaglandins, leukotrienes and other aspects of arachidonate metabolism. Leukotrienes 69-81 PCNA clamp associated factor Homo sapiens 28-31 1966811-0 1990 Enhancement of platelet-activating factor-induced leukotriene synthesis in neutrophils by granulocyte-macrophage colony-stimulating factor (GM-CSF): studies on the mechanism of action of GM-CSF. Leukotrienes 50-61 PCNA clamp associated factor Homo sapiens 15-41 1966811-1 1990 Preincubation with granulocyte-macrophage colony-stimulating factor (GM-CSF) increased the synthesis of leukotriene B4 and its omega-oxidation products by neutrophils in response to 10(-7) M platelet-activating factor (PAF) by more than 10-fold compared to untreated cells. Leukotrienes 104-115 PCNA clamp associated factor Homo sapiens 191-217 1966811-1 1990 Preincubation with granulocyte-macrophage colony-stimulating factor (GM-CSF) increased the synthesis of leukotriene B4 and its omega-oxidation products by neutrophils in response to 10(-7) M platelet-activating factor (PAF) by more than 10-fold compared to untreated cells. Leukotrienes 104-115 PCNA clamp associated factor Homo sapiens 219-222 2478607-12 1989 These data indicate that PAF is a significant RGC secretagogue that affects the RGC-secreting cells via the lipoxygenase pathway of arachidonic acid metabolism and the generation of leukotrienes in the airways, but not through the cholinergic receptors on the secretory cells. Leukotrienes 182-194 PCNA clamp associated factor Homo sapiens 25-28 2790041-1 1989 The aim of this study was to evaluate the role of platelet-activating factor (PAF) as a stimulator of leukotriene production by human monocytes. Leukotrienes 102-113 PCNA clamp associated factor Homo sapiens 50-76 2790041-1 1989 The aim of this study was to evaluate the role of platelet-activating factor (PAF) as a stimulator of leukotriene production by human monocytes. Leukotrienes 102-113 PCNA clamp associated factor Homo sapiens 78-81 6322256-1 1984 Polymorphonuclear neutrophils, when stimulated, rapidly form platelet-activating factor (PAF) and metabolize their arachidonate into 5-hydroperoxyeicosatetraenoate (5-HPETE), 5-hydroxyeicosatetraenoate (5-HETE), leukotriene (LT)A4, and LTB4. Leukotrienes 212-223 PCNA clamp associated factor Homo sapiens 89-92 3195800-10 1988 Other indirect effects, such as the release of sulfidopeptide leukotrienes, or a direct effect on airway smooth muscle may also contribute to PAF-induced bronchoconstriction. Leukotrienes 62-74 PCNA clamp associated factor Homo sapiens 142-145 3147587-4 1988 Leukotrienes (LTB4) are also powerful chemotactic factors and predominantly attract neutrophils, which stimulates dependent release lipid mediators (hydroxyeicosatetraenoic acids--HETES, leukotrienes, PAF) and thus amplify the inflammatory process. Leukotrienes 0-12 PCNA clamp associated factor Homo sapiens 201-204