PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30484341-8 2019 The cardiotoxicity associated with chronic coxib use, and the expectation that COX-2 inhibition will influence the levels of endocannabinoids, leukotrienes, and lipoxins as well as the prostaglandins and their endocannabinoid metabolite analogs, is shifting attention toward downstream synthases and receptors that mediate inflammation in the brain. Leukotrienes 143-155 prostaglandin-endoperoxide synthase 2 Homo sapiens 79-84 16417352-1 2006 5-Lipoxygenase and cyclooxygenase-2 (COX-2) initiate the biosynthesis of distinct families of mediators from arachidonic acid (leukotrienes and prostaglandins, respectively) and are each the target of anti-inflammatory medications. Leukotrienes 127-139 prostaglandin-endoperoxide synthase 2 Homo sapiens 19-35 21482803-1 2011 The prostaglandin and leukotriene families of lipid mediators are formed via two distinct biosynthetic pathways that are initiated by the oxygenation of arachidonic acid by either cyclooxygenase-2 (COX-2) or 5-lipoxygenase (5-LOX), respectively. Leukotrienes 22-33 prostaglandin-endoperoxide synthase 2 Homo sapiens 180-196 21482803-1 2011 The prostaglandin and leukotriene families of lipid mediators are formed via two distinct biosynthetic pathways that are initiated by the oxygenation of arachidonic acid by either cyclooxygenase-2 (COX-2) or 5-lipoxygenase (5-LOX), respectively. Leukotrienes 22-33 prostaglandin-endoperoxide synthase 2 Homo sapiens 198-203 16417352-1 2006 5-Lipoxygenase and cyclooxygenase-2 (COX-2) initiate the biosynthesis of distinct families of mediators from arachidonic acid (leukotrienes and prostaglandins, respectively) and are each the target of anti-inflammatory medications. Leukotrienes 127-139 prostaglandin-endoperoxide synthase 2 Homo sapiens 37-42 15705869-1 2005 Searching for a link between inflammation and colon cancer, we have found that the inflammatory mediator leukotriene D(4) (LTD(4)), via its receptor CysLT(1), induces cyclooxygenase-2 expression, survival, and proliferation in intestinal epithelial cells. Leukotrienes 105-116 prostaglandin-endoperoxide synthase 2 Homo sapiens 167-183 12604350-0 2003 Regulation of leukotriene-dependent induction of cyclooxygenase-2 and Bcl-2. Leukotrienes 14-25 prostaglandin-endoperoxide synthase 2 Homo sapiens 49-65 12604350-1 2003 Leukotrienes play an important pathophysiological role in chronic inflammatory states and, as previously shown, cause increased levels of cyclooxygenase-2 (COX-2) in intestinal epithelial cells. Leukotrienes 0-12 prostaglandin-endoperoxide synthase 2 Homo sapiens 138-154 12604350-1 2003 Leukotrienes play an important pathophysiological role in chronic inflammatory states and, as previously shown, cause increased levels of cyclooxygenase-2 (COX-2) in intestinal epithelial cells. Leukotrienes 0-12 prostaglandin-endoperoxide synthase 2 Homo sapiens 156-161