PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30484341-8	2019	The cardiotoxicity associated with chronic coxib use, and the expectation that COX-2 inhibition will influence the levels of endocannabinoids, leukotrienes, and lipoxins as well as the prostaglandins and their endocannabinoid metabolite analogs, is shifting attention toward downstream synthases and receptors that mediate inflammation in the brain.	Leukotrienes	143-155	prostaglandin-endoperoxide synthase 2	Homo sapiens	79-84	
16417352-1	2006	5-Lipoxygenase and cyclooxygenase-2 (COX-2) initiate the biosynthesis of distinct families of mediators from arachidonic acid (leukotrienes and prostaglandins, respectively) and are each the target of anti-inflammatory medications.	Leukotrienes	127-139	prostaglandin-endoperoxide synthase 2	Homo sapiens	19-35	
21482803-1	2011	The prostaglandin and leukotriene families of lipid mediators are formed via two distinct biosynthetic pathways that are initiated by the oxygenation of arachidonic acid by either cyclooxygenase-2 (COX-2) or 5-lipoxygenase (5-LOX), respectively.	Leukotrienes	22-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	180-196	
21482803-1	2011	The prostaglandin and leukotriene families of lipid mediators are formed via two distinct biosynthetic pathways that are initiated by the oxygenation of arachidonic acid by either cyclooxygenase-2 (COX-2) or 5-lipoxygenase (5-LOX), respectively.	Leukotrienes	22-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	198-203	
16417352-1	2006	5-Lipoxygenase and cyclooxygenase-2 (COX-2) initiate the biosynthesis of distinct families of mediators from arachidonic acid (leukotrienes and prostaglandins, respectively) and are each the target of anti-inflammatory medications.	Leukotrienes	127-139	prostaglandin-endoperoxide synthase 2	Homo sapiens	37-42	
15705869-1	2005	Searching for a link between inflammation and colon cancer, we have found that the inflammatory mediator leukotriene D(4) (LTD(4)), via its receptor CysLT(1), induces cyclooxygenase-2 expression, survival, and proliferation in intestinal epithelial cells.	Leukotrienes	105-116	prostaglandin-endoperoxide synthase 2	Homo sapiens	167-183	
12604350-0	2003	Regulation of leukotriene-dependent induction of cyclooxygenase-2 and Bcl-2.	Leukotrienes	14-25	prostaglandin-endoperoxide synthase 2	Homo sapiens	49-65	
12604350-1	2003	Leukotrienes play an important pathophysiological role in chronic inflammatory states and, as previously shown, cause increased levels of cyclooxygenase-2 (COX-2) in intestinal epithelial cells.	Leukotrienes	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	138-154	
12604350-1	2003	Leukotrienes play an important pathophysiological role in chronic inflammatory states and, as previously shown, cause increased levels of cyclooxygenase-2 (COX-2) in intestinal epithelial cells.	Leukotrienes	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	156-161