PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34137625-2	2021	The inflammatory cascade involves a multitude of cytokines ending ultimately with the activation of COX-2/LOX for the production of prostaglandins and leukotrienes.	Leukotrienes	151-163	cytochrome c oxidase II, mitochondrial	Mus musculus	100-105	
24795811-3	2014	Cyclooxygenase (COX-1 or COX-2) and 5-lipoxygenase (5-LO) catalyze the initial enzymatic steps in the synthesis of prostaglandins and leukotrienes, respectively.	Leukotrienes	134-146	cytochrome c oxidase II, mitochondrial	Mus musculus	25-30	
22551156-2	2012	Moreover, COX-2- and 5-lipoxygenase (5-LO)-derived prostaglandin and leukotriene biosynthesis can influence smooth muscle reactivity.	Leukotrienes	69-80	cytochrome c oxidase II, mitochondrial	Mus musculus	10-15	
22551156-12	2012	CONCLUSION AND IMPLICATIONS: The indomethacin-induced hypercontractility observed in Cav-1 KO tracheas was linked to increased expression of COX-2 and 5-LO, which probably enhanced arachidonic acid shunting and generation of pro-contractile leukotrienes when COX-2 was inhibited.	Leukotrienes	241-253	cytochrome c oxidase II, mitochondrial	Mus musculus	141-146	
15637091-10	2005	In summary, these results indicate that inhibition of COX-2 may lead to a shunt of arachidonic acid metabolism towards the leukotriene pathway during colonic tumorigenesis promoted by CSE.	Leukotrienes	123-134	cytochrome c oxidase II, mitochondrial	Mus musculus	54-59	
15223810-2	2004	Cyclooxygenase (COX)-2 is an enzyme that initiates the conversion of arachidonic acid (AA) into prostaglandins (PGs), whereas 5-lipoxygenase (5-LO) generates leukotrienes (LT).	Leukotrienes	158-170	cytochrome c oxidase II, mitochondrial	Mus musculus	0-22	
16272346-10	2005	Thus, deficiency of COX-1 and COX-2 leads to contrasting effects in the host response to influenza infection, and these differences are associated with altered production of prostaglandins and leukotrienes following infection.	Leukotrienes	193-205	cytochrome c oxidase II, mitochondrial	Mus musculus	30-35