PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31316498-1 2019 5-lipoxygenase (5-LOX) is a non-heme iron-containing dioxygenase expressed in immune cells that catalyzes the two initial steps in the biosynthesis of leukotrienes. Leukotrienes 151-163 lysyl oxidase Homo sapiens 18-21 33568930-10 2021 As leukotrienes formed via the 5-lipoxygenase (5-LOX) pathway also play an important role in the mediation of inflammation, efforts are also being made to target both COX and LOX pathways. Leukotrienes 3-15 lysyl oxidase Homo sapiens 49-52 28791741-3 2018 Leukotrienes biosynthesis is initiated by the action of 5-LOX at the level of nuclear membrane and the mechanism of enzyme-membrane interaction is thought to involve structural flexibility and conformational changes at the level of the protein tertiary structure. Leukotrienes 0-12 lysyl oxidase Homo sapiens 58-61 29355395-1 2018 Prostaglandins and leukotrienes are produced in the COX and 5-LOX pathways of the inflammatory process. Leukotrienes 19-31 lysyl oxidase Homo sapiens 62-65 27363940-1 2016 Human 5-lipoxygenase (5-LOX) is responsible for the formation of leukotriene (LT)A4, a pivotal intermediate in the biosynthesis of the leukotrienes, a family of proinflammatory lipid mediators. Leukotrienes 135-147 lysyl oxidase Homo sapiens 24-27 27597418-1 2016 The biosynthesis of leukotrienes in one of the arachidonic acid pathways and PGE2 in the other by 5-LOX and mPGES1 respectively, play pivotal roles in augmenting inflammatory responses. Leukotrienes 20-32 lysyl oxidase Homo sapiens 100-103 27033421-1 2016 Human neutrophil 5-lipoxygenase (5-LOX) oxidizes arachidonic acid (AA) to 5S-hydro(pero)xy-6E,8Z,11Z, 14Z-eicosatetraenoic acid (5-H(p)ETE) and leukotriene (LT)A4, which is further converted to the chemoattractant LTB4. Leukotrienes 144-155 lysyl oxidase Homo sapiens 35-38 29648709-1 2016 Leukotrienes (LTs) belong to pro-inflammatory mediators that are biosynthesized from arachidonic acid (AA), inter alia, by 5-lipoxygenase (5-LOX) enzyme in association with 5-LOX-activating protein (FLAP). Leukotrienes 0-12 lysyl oxidase Homo sapiens 141-144 29648709-1 2016 Leukotrienes (LTs) belong to pro-inflammatory mediators that are biosynthesized from arachidonic acid (AA), inter alia, by 5-lipoxygenase (5-LOX) enzyme in association with 5-LOX-activating protein (FLAP). Leukotrienes 0-12 lysyl oxidase Homo sapiens 175-178 29648709-1 2016 Leukotrienes (LTs) belong to pro-inflammatory mediators that are biosynthesized from arachidonic acid (AA), inter alia, by 5-lipoxygenase (5-LOX) enzyme in association with 5-LOX-activating protein (FLAP). Leukotrienes 14-17 lysyl oxidase Homo sapiens 141-144 29648709-1 2016 Leukotrienes (LTs) belong to pro-inflammatory mediators that are biosynthesized from arachidonic acid (AA), inter alia, by 5-lipoxygenase (5-LOX) enzyme in association with 5-LOX-activating protein (FLAP). Leukotrienes 14-17 lysyl oxidase Homo sapiens 175-178 27161402-11 2016 Moreover, the plant extract blocked leukotriene LTB4 release, the major end product of the 5-LOX pathway from PBMC. Leukotrienes 36-47 lysyl oxidase Homo sapiens 93-96 24480307-1 2014 5-Lipoxygenase (5-LOX) catalyzes two steps in conversion of arachidonic acid to proinflammatory leukotrienes. Leukotrienes 96-108 lysyl oxidase Homo sapiens 18-21 25246560-2 2014 The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of proinflammatory leukotriene B4 (LTB4), whereas, in theory, cytoplasmic 5-LOX could favor the biosynthesis of proresolving lipoxin A4 (LXA4). Leukotrienes 209-220 lysyl oxidase Homo sapiens 146-149 25246560-2 2014 The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of proinflammatory leukotriene B4 (LTB4), whereas, in theory, cytoplasmic 5-LOX could favor the biosynthesis of proresolving lipoxin A4 (LXA4). Leukotrienes 209-220 lysyl oxidase Homo sapiens 162-165 25246560-2 2014 The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of proinflammatory leukotriene B4 (LTB4), whereas, in theory, cytoplasmic 5-LOX could favor the biosynthesis of proresolving lipoxin A4 (LXA4). Leukotrienes 209-220 lysyl oxidase Homo sapiens 162-165 23727898-3 2013 We found a significant increase in 5-LOX gene expression in AD subjects compared to healthy controls, paralleled by increased 5-LOX protein and leukotriene B4, the 5-LOX product. Leukotrienes 144-155 lysyl oxidase Homo sapiens 37-40 23752617-1 2013 Leukotrienes are the bioactive group of fatty acids and major constituents of arachidonic acid metabolism molded by the catalytic activity of 5-lipoxygenase (5-LOX). Leukotrienes 0-12 lysyl oxidase Homo sapiens 160-163 20181674-0 2010 "Lox on neovascularization": leukotrienes as mediators in endothelial biology. Leukotrienes 29-41 lysyl oxidase Homo sapiens 1-4 21169551-1 2011 Leukotrienes generated by 5-lipoxygenase (5-LOX)-catalyzed reaction are key regulators of inflammation. Leukotrienes 0-12 lysyl oxidase Homo sapiens 44-47 20016244-2 2009 LOX enzymes catalyze the dioxygenation of arachidonic acid into hydroxyperoxyeicosatetraenoic acids, which is followed by their conversion to their corresponding eicosanoids as hydroxyeicosatetraenoic acids, leukotrienes, lipoxins and hepoxilins, which in turn act as cellular messengers. Leukotrienes 208-220 lysyl oxidase Homo sapiens 0-3 17305569-5 2007 It is further advantageous for a drug to have both COX and 5-LOX inhibiting activities because prostaglandins enhance leukotriene-mediated inflammation. Leukotrienes 118-129 lysyl oxidase Homo sapiens 61-64 18448265-5 2008 Recent studies showed that lipoxidase/leukotrienes (LOX/LTs) pathway played important role in the ignition and development of atherosclerosis, whereas resolvins (E-series resolvins and D-series resolvins) and protectins [protectin D1 (PD1) and neuroprotectin D1 (NPD1)], endogenous lipid-derived mediators, inhibited inflammation through pro-resolution and counter-modulating immune inflammation reaction in atherosclerosis. Leukotrienes 38-50 lysyl oxidase Homo sapiens 52-55 17484769-1 2007 5-Lipoxygenase (5-LOX) is the key enzyme responsible for the synthesis of the biologically active leukotrienes. Leukotrienes 98-110 lysyl oxidase Homo sapiens 18-21 17305569-8 2007 Indeed, both COX-2 and 5-LOX are also involved in the development and progression of several types of cancer; in these conditions, selective inhibition of COX-2 alone may lead to a shunt of arachidonic acid metabolism towards the leukotriene pathway, and therefore the blockade of both COX-2 and 5-LOX may produce a better anticancer response. Leukotrienes 230-241 lysyl oxidase Homo sapiens 25-28 10877840-3 2000 Lipoxygenases are enzymes that, as cyclooxygenases (COX), can insert oxygen into the molecule of arachidonic acid and thereby synthesize inflammatory eicosanoids: leukotrienes [due to 5-lipoxygenase (5-LOX) activity] and prostaglandins (via COX activity). Leukotrienes 163-175 lysyl oxidase Homo sapiens 202-205 11966455-7 2002 Finally, both COX and LOX derivatives (prostanoids and leukotrienes, respectively) are involved in other diseases than inflammation such as cancer proliferation where the use of dual inhibitors could be an interesting approach. Leukotrienes 55-67 lysyl oxidase Homo sapiens 22-25 11728379-7 2001 Arachidonic acid can also be converted to leukotrienes (LTs) by the action of 5-lipoxygenase (5-LOX). Leukotrienes 42-54 lysyl oxidase Homo sapiens 96-99 11728379-7 2001 Arachidonic acid can also be converted to leukotrienes (LTs) by the action of 5-lipoxygenase (5-LOX). Leukotrienes 56-59 lysyl oxidase Homo sapiens 96-99 9630716-4 1998 MK-886, a potent inhibitor of leukotriene biosynthesis, blocked the FLAP dependent S.t.LOX activation after preincubation with FLAP transfected membranes. Leukotrienes 30-41 lysyl oxidase Homo sapiens 87-90 10381823-2 1999 5-lipoxygenase (5-LOX) catalyses the first steps in the synthesis of leukotrienes from arachidonic acid, and its activity is dependent on 5-LOX activating protein (FLAP). Leukotrienes 69-81 lysyl oxidase Homo sapiens 18-21 10381823-2 1999 5-lipoxygenase (5-LOX) catalyses the first steps in the synthesis of leukotrienes from arachidonic acid, and its activity is dependent on 5-LOX activating protein (FLAP). Leukotrienes 69-81 lysyl oxidase Homo sapiens 140-143 7741044-7 1994 The use of BAY X 1005 has helped to elucidate part of the complex FLAP/5-LOX interaction by showing that FLAP appears to represent a 5-LOX substrate transfer protein channelling endogenous and exogenous arachidonic acid to the leukotriene synthetizing 5-LOX. Leukotrienes 227-238 lysyl oxidase Homo sapiens 73-76 7741044-7 1994 The use of BAY X 1005 has helped to elucidate part of the complex FLAP/5-LOX interaction by showing that FLAP appears to represent a 5-LOX substrate transfer protein channelling endogenous and exogenous arachidonic acid to the leukotriene synthetizing 5-LOX. Leukotrienes 227-238 lysyl oxidase Homo sapiens 135-138 7741044-7 1994 The use of BAY X 1005 has helped to elucidate part of the complex FLAP/5-LOX interaction by showing that FLAP appears to represent a 5-LOX substrate transfer protein channelling endogenous and exogenous arachidonic acid to the leukotriene synthetizing 5-LOX. Leukotrienes 227-238 lysyl oxidase Homo sapiens 135-138 8031320-1 1994 A series of quinoline derivatives were analysed for the influence on leukotriene synthesis as a parameter for 5-LOX (EC 1.13.11.34) activity in a cell-free system of the 10,000 g supernatant of human PMNL (polymorphonuclear leukocytes). Leukotrienes 69-80 lysyl oxidase Homo sapiens 112-115 34487716-3 2021 We describe herein early work identifying 5-LOX as the key enzyme that initiates LT biosynthesis and the discovery of its membrane-embedded helper protein required to execute the two-step reaction that transforms AA to the progenitor leukotriene A4 (LTA4). Leukotrienes 234-245 lysyl oxidase Homo sapiens 44-47