PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26090892-0	2015	TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells.	TAE226	0-6	epidermal growth factor receptor	Mus musculus	56-60	
26090892-0	2015	TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells.	TAE226	0-6	epidermal growth factor receptor	Mus musculus	127-131	
26090892-3	2015	TAE226 was more effective against cells with mutant EGFR, including the T790M mutant, than against cells with wild-type one.	TAE226	0-6	epidermal growth factor receptor	Mus musculus	52-56	
26090892-4	2015	TAE226 preferentially inhibited phospho-EGFR and its downstream signaling mediators in the cells with mutant EGFR than in those with wild-type one.	TAE226	0-6	epidermal growth factor receptor	Mus musculus	40-44	
26090892-4	2015	TAE226 preferentially inhibited phospho-EGFR and its downstream signaling mediators in the cells with mutant EGFR than in those with wild-type one.	TAE226	0-6	epidermal growth factor receptor	Mus musculus	109-113	
26090892-7	2015	Of interest, the L858R/T790M or delE746_A750/T790M mutant enhanced the binding affinity for TAE226 compared with the L858R or delE746_A750 mutant, resulting in the effectiveness of TAE226 against T790M mutant cells despite the T790M mutation restoring the ATP affinity for the mutant EGFR close to that for the wild-type.	TAE226	92-98	epidermal growth factor receptor	Mus musculus	284-288	
26090892-7	2015	Of interest, the L858R/T790M or delE746_A750/T790M mutant enhanced the binding affinity for TAE226 compared with the L858R or delE746_A750 mutant, resulting in the effectiveness of TAE226 against T790M mutant cells despite the T790M mutation restoring the ATP affinity for the mutant EGFR close to that for the wild-type.	TAE226	181-187	epidermal growth factor receptor	Mus musculus	284-288	
26090892-10	2015	In summary, we showed that TAE226 inhibited the activation of mutant EGFR and exhibited anti-proliferative activity against NSCLCs carrying EGFR mutations, including T790M mutation.	TAE226	27-33	epidermal growth factor receptor	Mus musculus	69-73	
26090892-10	2015	In summary, we showed that TAE226 inhibited the activation of mutant EGFR and exhibited anti-proliferative activity against NSCLCs carrying EGFR mutations, including T790M mutation.	TAE226	27-33	epidermal growth factor receptor	Mus musculus	140-144