PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18534085-10	2008	The correlation coefficient (r) between the changes in TNF-alpha values between 3 and 12 months of SIT and provocative concentrations of methacholine to cause a 20% fall in FEV(1) (PC20M) after 12 months of SIT was positive (r = 0.76; p < 0.0001); the greater the changes in TNF-alpha level, the higher the PC20.	Methacholine Chloride	137-149	tumor necrosis factor	Homo sapiens	278-287	
25202844-9	2015	However, there was a positive association between the degree of AHR to methacholine and serum levels of TNF-alpha (r = 0.36, P = 0.04).	Methacholine Chloride	71-83	tumor necrosis factor	Homo sapiens	104-113	
11264706-3	2001	Inhaled TNF-alpha increases airway responsiveness to methacholine in normal and asthmatic subjects associated with a sputum neutrophilia.	Methacholine Chloride	53-65	tumor necrosis factor	Homo sapiens	8-17	
12583324-8	2002	Significant negative correlation was detected between the serum TNF-alpha and sTNF-R2 concentrations and PD20 FEV1 methacholin (dose of methacholin resulting in a 20% reduction of forced exspiratory volume in 1 second) in hyperreactive patients.	Methacholine Chloride	115-126	tumor necrosis factor	Homo sapiens	64-73	
12583324-8	2002	Significant negative correlation was detected between the serum TNF-alpha and sTNF-R2 concentrations and PD20 FEV1 methacholin (dose of methacholin resulting in a 20% reduction of forced exspiratory volume in 1 second) in hyperreactive patients.	Methacholine Chloride	136-147	tumor necrosis factor	Homo sapiens	64-73	
16815142-10	2006	In addition, the levels of both TNF-alpha and TGF-beta were significantly correlated with the methacholine threshold and peak expiratory flow variability for the week.	Methacholine Chloride	94-106	tumor necrosis factor	Homo sapiens	32-41	
12644720-7	2003	Allergen challenge and clinical asthma are associated with synthesis and release of pro-inflammatory cytokines such as IL-1 and TNF-alpha which have been shown to decrease the response to beta-agonists and increased the reactivity to methacholine and the airways neutrophils and alveolar macrophages.	Methacholine Chloride	234-246	tumor necrosis factor	Homo sapiens	128-137