PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16393274-3	2006	This study investigated whether an anti-TNF-alpha antibody would inhibit pulmonary inflammation and methacholine (Mch) hyper-responsiveness in a mouse model of asthma induced by a house dust extract containing both endotoxin and cockroach allergens.	Methacholine Chloride	100-112	tumor necrosis factor	Mus musculus	40-49	
16393274-3	2006	This study investigated whether an anti-TNF-alpha antibody would inhibit pulmonary inflammation and methacholine (Mch) hyper-responsiveness in a mouse model of asthma induced by a house dust extract containing both endotoxin and cockroach allergens.	Methacholine Chloride	114-117	tumor necrosis factor	Mus musculus	40-49	
12356572-5	2002	Airway inflammation, goblet cell metaplasia, epithelial cell damage, and nonspecific airway reactivity to methacholine challenge, measured 24 h following the last challenge, were reduced to baseline levels in TNF-alpha null mice and athymic mice.	Methacholine Chloride	106-118	tumor necrosis factor	Mus musculus	209-218	
26717421-7	2016	RESULTS: Treatment of anti-TNF-alpha mAb during sensitization period significantly reduced airway eosinophilia, serum OVA-specific IgE levels and methacholine AHR compared to isotype Ab.	Methacholine Chloride	146-158	tumor necrosis factor	Mus musculus	27-36	
22481960-6	2012	We observed that preincubation of the tracheal rings with LPS for 90 min enhanced the subsequent MCh-induced contractile response (hyperreactivity), which was prevented by prior neutralization of TNFalpha with a specific antibody.	Methacholine Chloride	97-100	tumor necrosis factor	Mus musculus	196-204	
25594684-5	2015	Intranasal challenge of Cd38-deficient mice with TNF-alpha or IL-13, or the environmental fungus Alternaria alternata, causes significantly attenuated methacholine responsiveness compared with wild-type mice, with comparable airway inflammation.	Methacholine Chloride	151-163	tumor necrosis factor	Mus musculus	49-58	
21297077-8	2011	In Balb/c mice, dominant-negative TNF biologics administered during immunization decreased the recruitment of eosinophils and lymphocytes into the bronchoalveolar space and lung parenchyma, reduced specific serum IgE, goblet-cell hyperplasia, and eosinophilic inflammation, and suppressed methacholine-induced airway hyperreactivity.	Methacholine Chloride	289-301	tumor necrosis factor	Mus musculus	34-37	
21951583-5	2011	3 In naive mice, responsiveness to MCh was significantly increased by the combination of IL-1beta and TNF-alpha, IL-13 alone or in combination with IL-1beta, but not by treatment with IL-1beta or TNF-alpha alone.	Methacholine Chloride	35-38	tumor necrosis factor	Mus musculus	102-111