PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10351919-1	1999	Short-acting beta2-agonists provide greater protection against bronchoconstriction induced by adenosine 5"-monophosphate (AMP) than by direct-acting bronchoconstrictors such as histamine and methacholine.	Methacholine Chloride	191-203	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	13-18	
10329815-2	1999	OBJECTIVES: The primary aim of this study was to evaluate whether there is a potential in vivo interaction between long- and short-acting beta2-agonists in the presence of increased airway tone induced by methacholine.	Methacholine Chloride	205-217	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	138-143	
10378545-4	1999	RESULTS: Inhalation of the beta2-agonist was associated with an increase in provocative concentration causing a 20% decrease in FEV1 (PC20) values (geometric mean) from 1.01+/-2.76 to 20.54+/-6.24 mg/mL for methacholine and from 2.29+/-2.26 to 19.82+/-5.93 mg/mL for histamine.	Methacholine Chloride	207-219	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	27-32	
9310023-2	1997	With short-acting beta 2-agonists, this is more readily demonstrable using indirectly acting agents such as adenosine monophosphate (AMP), which may act via mast cell degranulation, than using methacholine (MCh), implying more rapid mast cell than smooth muscle desensitization.	Methacholine Chloride	207-210	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	18-24	
9412548-2	1997	Because AMP produces bronchoconstriction through release of mediators from mast cells, and methacholine directly constricts airway smooth muscle, this suggests that beta(2)-agonists stabilize mast cells in vivo.	Methacholine Chloride	91-103	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	165-171	
9139768-1	1997	After complete abstinence, regular use of short-acting beta 2-agonists results in an increase in early and late asthmatic (allergen) response, exercise-induced bronchoconstriction, and nonspecific airways responsiveness (methacholine).	Methacholine Chloride	221-233	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	55-61	
9139768-2	1997	Regular use of long-acting beta 2-agonists also results in increased nonspecific airways responsiveness (methacholine) with or without concomitant inhaled corticosteroids and attenuates the response to escalating doses of inhaled short-acting beta 2-agonists such as might be used in an acute exacerbation.	Methacholine Chloride	105-117	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	27-33	
8568137-1	1996	BACKGROUND: Two adverse effects of inhaled beta 2-agonists are increased airway responsiveness to allergen and tolerance to the bronchoprotective effect of beta 2-agonists versus bronchoconstrictors (e.g., methacholine).	Methacholine Chloride	206-218	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	43-49	
1673830-0	1991	Prolonged protection against methacholine-induced bronchoconstriction by the inhaled beta 2-agonist formoterol.	Methacholine Chloride	29-41	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	85-91	
7582281-0	1995	Interaction of inhaled beta 2 agonist and inhaled corticosteroid on airway responsiveness to allergen and methacholine.	Methacholine Chloride	106-118	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	23-29	
7750333-0	1995	The reversibility of airway obstruction to an inhaled beta 2-adrenergic agent is less satisfactory after methacholine testing in asthmatic subjects.	Methacholine Chloride	105-117	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	54-60	
7750333-1	1995	AIMS: The aim of this work was to compare the response to an inhaled beta 2-adrenergic agent in two situations: (1) spontaneous airway obstruction in asthmatic subjects who had withheld treatment with the medication for more than 12 hs; and (2) after methacholine-induced airway obstruction once airway caliber had recovered to the premethacholine test value.	Methacholine Chloride	251-263	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	69-75	
7750333-7	1995	CONCLUSION: After a methacholine test, the reversibility of an inhaled beta 2 agent is not significantly different from a placebo and is less satisfactory than in a situation of spontaneous airway obstruction.	Methacholine Chloride	20-32	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	71-77	
8296255-0	1993	Changes in methacholine induced bronchoconstriction with the long acting beta 2 agonist salmeterol in mild to moderate asthmatic patients.	Methacholine Chloride	11-23	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	73-79	
8296255-1	1993	BACKGROUND: Beta-2 agonists protect against non-specific bronchoconstricting agents such as methacholine, but it has been suggested that the protection afforded by long acting beta 2 agonists wanes rapidly with regular treatment.	Methacholine Chloride	92-104	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	12-18	
8104272-1	1993	Regular inhaled beta 2 agonist causes tolerance to the acute protective effect of beta 2 agonist against bronchoconstriction induced by chemical stimuli such as AMP, histamine, and methacholine.	Methacholine Chloride	181-193	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	16-22	
8104272-1	1993	Regular inhaled beta 2 agonist causes tolerance to the acute protective effect of beta 2 agonist against bronchoconstriction induced by chemical stimuli such as AMP, histamine, and methacholine.	Methacholine Chloride	181-193	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	82-88	
8099699-6	1993	Single doses of long-acting beta 2-agonists give a prolonged protection against methacholine- and histamine-induced airway sensitivity of at least 12 hours.	Methacholine Chloride	80-92	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	28-34	
2566160-0	1989	[Effectiveness of a new beta 2-agonist (broxaterol) on bronchospasm induced by methacholine (blind study versus salbutamol)].	Methacholine Chloride	79-91	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	24-30	
15338791-0	2004	Relief of dyspnoea by beta2-agonists after methacholine-induced bronchoconstriction.	Methacholine Chloride	43-55	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	22-27	
21923426-0	2011	Methacholine challenge as a clinical bioassay of pulmonary delivery of a long-acting beta2-adrenergic agonist.	Methacholine Chloride	0-12	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	85-90	
21923426-1	2011	STUDY OBJECTIVE: To determine whether the methacholine challenge method used for albuterol can be applied to assess long-acting beta2-adrenergic agonist (LABA) bioequivalence, which would require a sufficiently steep dose-response curve.	Methacholine Chloride	42-54	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	128-133	
12640377-6	2003	The only significant relationship between asthma severity and height percentile was with methacholine bronchoprovocation in girls (beta 2.98, P =.019, covariate multiple regression).	Methacholine Chloride	89-101	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	131-137