PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
4878435-0	1968	Effects of methacholine on insulin secretion in man.	Methacholine Chloride	11-23	insulin	Homo sapiens	27-34	
4918328-3	1970	In concentrations identical with those considered necessary for adequate anticonvulsant therapy in man, DPH markedly decreases the insulin secretory response of pancreatic pieces to methacholine, 1 mug/ml, tolbutamide, 250 mug/ml, and glucose, 200 mg/100 ml, without any demonstrable alteration in the oxidative conversion of glucose-1-(14)C or glucose-6-(14)C to (14)CO(2) by isolated islets.	Methacholine Chloride	182-194	insulin	Homo sapiens	131-138	
33501891-8	2021	Insulin, not IGF-1, significantly increased methacholine-induced contraction of rat and human isolated airway smooth muscle.	Methacholine Chloride	44-56	insulin	Homo sapiens	0-7	
33501891-9	2021	In cultured rat tracheal smooth muscle cells, insulin significantly increased M2, not M3, mRNA expression and enhanced methacholine- and serotonin-induced increase in intracellular calcium.	Methacholine Chloride	119-131	insulin	Homo sapiens	46-53	
9276741-8	1997	Replacement of basal insulin levels during SRIF resulted in a fall of FFA levels from 545+/-47 to 228+/-61 micromol, and prevented the impairment of Mch-induced vasodilation seen with SRIF alone.	Methacholine Chloride	149-152	insulin	Homo sapiens	21-28	
10905485-6	2000	We found a positive relationship between the Mch-modulated increase in LGU and insulin sensitivity (GDR) (r = 0.60, P < 0.02), suggesting that the most insulin-sensitive subjects had the greatest enhancement of LGU in response to augmentation of muscle perfusion.	Methacholine Chloride	45-48	insulin	Homo sapiens	79-86	
10905485-6	2000	We found a positive relationship between the Mch-modulated increase in LGU and insulin sensitivity (GDR) (r = 0.60, P < 0.02), suggesting that the most insulin-sensitive subjects had the greatest enhancement of LGU in response to augmentation of muscle perfusion.	Methacholine Chloride	45-48	insulin	Homo sapiens	155-162	
10418855-5	1999	Studies of the response to the endothelium-dependent vasodilator methacholine chloride in lean and obese nondiabetic subjects and obese subjects with type 2 diabetes mellitus indicate that there may be marked endothelial dysfunction very early in insulin resistance.	Methacholine Chloride	65-86	insulin	Homo sapiens	247-254