PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2182697-3 1990 Thus, this dose of beta 2-adrenoceptor agonist displaced the concentration-response curves for methacholine, histamine, and AMP to the right in a parallel fashion by 8.8 (0.6 to 29.3)-, 10.3 (1.4 to 33)-, and 26.6 (1.5 to 76.6)-fold, respectively, the difference between the results for AMP and those for histamine and methacholine being statistically significant (p less than 0.01). Methacholine Chloride 95-107 adrenoceptor beta 2 Homo sapiens 19-38 2182697-3 1990 Thus, this dose of beta 2-adrenoceptor agonist displaced the concentration-response curves for methacholine, histamine, and AMP to the right in a parallel fashion by 8.8 (0.6 to 29.3)-, 10.3 (1.4 to 33)-, and 26.6 (1.5 to 76.6)-fold, respectively, the difference between the results for AMP and those for histamine and methacholine being statistically significant (p less than 0.01). Methacholine Chloride 319-331 adrenoceptor beta 2 Homo sapiens 19-38 25799096-9 2015 The addition of ASM-024 relaxed concentration-dependently intact or beta2-AR desensitized tracheal rings precontracted with methacholine. Methacholine Chloride 124-136 adrenoceptor beta 2 Homo sapiens 68-76 23384627-0 2013 Methacholine PC20 in African Americans and whites with asthma with homozygous genotypes at ADRB2 codon 16. Methacholine Chloride 0-12 adrenoceptor beta 2 Homo sapiens 91-96 23384627-2 2013 Adrenoceptor beta 2, surface gene (ADRB2) Gly16Arg genotypes have been associated with beta2-agonist bronchodilator response, asthma exacerbation rate, response to methacholine, and lung function decline but not specifically in African Americans. Methacholine Chloride 164-176 adrenoceptor beta 2 Homo sapiens 0-19 23384627-2 2013 Adrenoceptor beta 2, surface gene (ADRB2) Gly16Arg genotypes have been associated with beta2-agonist bronchodilator response, asthma exacerbation rate, response to methacholine, and lung function decline but not specifically in African Americans. Methacholine Chloride 164-176 adrenoceptor beta 2 Homo sapiens 35-40 23384627-3 2013 OBJECTIVE: We sought to compare the provocative concentration of methacholine that causes a 20% fall in FEV1 (PC20) in African Americans and whites with asthma who were ADRB2 homozygous at codon 16 (Arg16Arg or Gly16Gly). Methacholine Chloride 65-77 adrenoceptor beta 2 Homo sapiens 169-174 23548524-0 2013 Influence of beta(2)-adrenergic receptor polymorphism on methacholine hyperresponsiveness in asthmatic patients. Methacholine Chloride 57-69 adrenoceptor beta 2 Homo sapiens 13-40 23548524-3 2013 OBJECTIVE: To assess the effect of the ADRB2 polymorphism in methacholine-responsive patients with asthma. Methacholine Chloride 61-73 adrenoceptor beta 2 Homo sapiens 39-44 12905693-5 2002 The dose of methacholine was low in asthmatics carrying Gln27 homozygous beta 2AR than Glu27 homozygous beta 2AR and Gln/Glu27 heterozygous beta 2AR in brocho-challenge test [(0.205 +/- 0.275) vs (2.11 +/- 3.00) vs (1.575 +/- 0.828) mumol, P < 0.05]. Methacholine Chloride 12-24 adrenoceptor beta 2 Homo sapiens 73-81 12905693-5 2002 The dose of methacholine was low in asthmatics carrying Gln27 homozygous beta 2AR than Glu27 homozygous beta 2AR and Gln/Glu27 heterozygous beta 2AR in brocho-challenge test [(0.205 +/- 0.275) vs (2.11 +/- 3.00) vs (1.575 +/- 0.828) mumol, P < 0.05]. Methacholine Chloride 12-24 adrenoceptor beta 2 Homo sapiens 104-112 12905693-5 2002 The dose of methacholine was low in asthmatics carrying Gln27 homozygous beta 2AR than Glu27 homozygous beta 2AR and Gln/Glu27 heterozygous beta 2AR in brocho-challenge test [(0.205 +/- 0.275) vs (2.11 +/- 3.00) vs (1.575 +/- 0.828) mumol, P < 0.05]. Methacholine Chloride 12-24 adrenoceptor beta 2 Homo sapiens 104-112 8655889-1 1996 BACKGROUND: Inhalation of a single dose of the long-acting beta 2-adrenoceptor agonist salmeterol protects against methacholine-induced airway obstruction and other bronchoconstricting stimuli for at least 12 hours. Methacholine Chloride 115-127 adrenoceptor beta 2 Homo sapiens 59-78 7901034-0 1993 Chronic exposure to a beta 2-adrenoceptor agonist increases the airway response to methacholine. Methacholine Chloride 83-95 adrenoceptor beta 2 Homo sapiens 22-41 7901034-2 1993 We wanted to determine whether a 28-day in vivo exposure to albuterol (beta 2-adrenoceptor agonist) altered the response of rabbit airways to the cholinergic agonist methacholine. Methacholine Chloride 166-178 adrenoceptor beta 2 Homo sapiens 71-90 7901034-8 1993 These data demonstrate that chronic in vivo exposure to a beta 2-adrenoceptor agonist can alter the in vitro tissue bath response of airway smooth muscle to methacholine. Methacholine Chloride 157-169 adrenoceptor beta 2 Homo sapiens 58-77 16899844-12 2006 CONCLUSION: This study indicates that a specific beta(2)-AR polymorphism at codon 16 might be a genetic determinant of AHR, as judged by methacholine-induced bronchoconstriction in asymptomatic healthy subjects. Methacholine Chloride 137-149 adrenoceptor beta 2 Homo sapiens 49-59 11888952-1 2002 STUDY OBJECTIVES: To exclude genetic linkage between the beta(2)-adrenoceptor gene and asthma, allergy, and methacholine airway hyperresponsiveness. Methacholine Chloride 108-120 adrenoceptor beta 2 Homo sapiens 57-77