PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15195554-1	2004	Although angiotensin II (Ang II) causes bronchoconstriction and bronchial hyperresponsiveness to methacholine in mildly asthmatic patients, the responsible mechanisms for these reactions are unclear.	Methacholine Chloride	97-109	angiotensinogen	Homo sapiens	9-23	
8620948-0	1995	Angiotensin II potentiates methacholine-induced bronchoconstriction in human airway both in vitro and in vivo.	Methacholine Chloride	27-39	angiotensinogen	Homo sapiens	0-14	
8620948-9	1995	Pre-incubation with low concentrations of angiotensin II significantly enhanced contractions to methacholine.	Methacholine Chloride	96-108	angiotensinogen	Homo sapiens	42-56	
8620948-11	1995	Compared to placebo, angiotensin II 2 ng.kg-1.min, but not 1 ng.kg-1.min, evoked a significant increase in bronchial reactivity to methacholine.	Methacholine Chloride	131-143	angiotensinogen	Homo sapiens	21-35	
8620948-12	1995	Angiotensin II in subthreshold concentrations enhances methacholine-evoked bronchoconstrictions both in human in vitro and in mild asthmatic patients in vivo.	Methacholine Chloride	55-67	angiotensinogen	Homo sapiens	0-14	
8667214-4	1996	The preferential inhibitory effect of platelet-activating factor on angiotensin II-mediated renal vasoconstriction was mimicked by the intrarenal infusion of either 0.2 to 5 micrograms/min/kg methacholine (endothelium-dependent vasodilator) or 2 micrograms/min/kg sodium nitroprusside (nitric oxide donor).	Methacholine Chloride	192-204	angiotensinogen	Homo sapiens	68-82	
8667214-5	1996	After inhibition of nitric oxide synthesis with NG-monomethyl-L-arginine, intrarenal infusion of PAF or methacholine reduced angiotensin II-mediated renal vasoconstriction significantly less than that observed in the absence of NG-monomethyl-L-arginine.	Methacholine Chloride	104-116	angiotensinogen	Homo sapiens	125-139	
8667214-6	1996	Therefore, this study provides evidence that the shared ability of platelet-activating factor and methacholine to selectively reduce angiotensin II-mediated renal vasoconstriction involves endothelium-derived nitric oxide.	Methacholine Chloride	98-110	angiotensinogen	Homo sapiens	133-147	
15195554-1	2004	Although angiotensin II (Ang II) causes bronchoconstriction and bronchial hyperresponsiveness to methacholine in mildly asthmatic patients, the responsible mechanisms for these reactions are unclear.	Methacholine Chloride	97-109	angiotensinogen	Homo sapiens	25-31	
15195554-6	2004	The Ang II infusion elicited bronchial hyperresponsiveness to methacholine.	Methacholine Chloride	62-74	angiotensinogen	Homo sapiens	4-10	
15195554-7	2004	The provocative concentration of methacholine, which produced a 200% increase above the baseline Pao (PC200), decreased from 306.9 to 156.1 micrograms/mL upon Ang II infusion.	Methacholine Chloride	33-45	angiotensinogen	Homo sapiens	159-165	
15195554-9	2004	The authors conclude that Ang II caused bronchoconstriction and induced bronchial hyperresponsiveness to methacholine via the AT1 receptors and that this effect did not involve the release of other bronchoactive mediators.	Methacholine Chloride	105-117	angiotensinogen	Homo sapiens	26-32	
9488894-2	1997	Angiotensin II causes bronchoconstriction in mild asthmatics and potentiates methacholine-evoked bronchoconstriction both in vitro and in vivo.	Methacholine Chloride	77-89	angiotensinogen	Homo sapiens	0-14	
10027431-2	1999	Angiotensin II (Ang II) is increased in plasma in acute severe asthma, causes bronchoconstriction in asthmatics, and potentiates contractions induced by ET-1 in bovine bronchial smooth muscle in vitro, and contractions induced by methacholine both in vitro and in vivo.	Methacholine Chloride	230-242	angiotensinogen	Homo sapiens	0-14	
14510783-8	2003	Methacholine (50 nm) antagonised Ang II-facilitated autoregulation in the presence and absence of NOS/COX inhibition.	Methacholine Chloride	0-12	angiotensinogen	Homo sapiens	33-39