PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2209152-4 1990 We sought to elucidate the role of PAF in airway hyperreactivity by comparing the effect of inhaled PAF on methacholine and isoproterenol airway responsiveness in six nonasthmatic and six asthmatic subjects. Methacholine Chloride 107-119 PCNA clamp associated factor Homo sapiens 100-103 8836652-8 1996 The provocative dose of PAF causing a 35% fall in sGaw (PD35,sGaw) PAF was only twofold lower in the asthmatics than in the normal subjects (p < 0.05), while it was 11 fold lower for methacholine (p < 0.001). Methacholine Chloride 186-198 PCNA clamp associated factor Homo sapiens 24-27 8000412-5 1994 Two days after PAF inhalation a leftward shift of the concentration-response curve to MCh was observed. Methacholine Chloride 86-89 PCNA clamp associated factor Homo sapiens 15-18 8000412-6 1994 The MCh concentration causing a 20% fall in FEV1 (PC20FEV1) was 11.25 +/- 1.78 and 2.38 +/- 1.29 mg.ml-1 (geometric mean +/- GSEM; p < 0.05) before and after PAF inhalation, respectively. Methacholine Chloride 4-7 PCNA clamp associated factor Homo sapiens 161-164 1657632-7 1991 Only three out of seven subjects showed a bronchial hyperresponsiveness to methacholine measured 24 h after PAF. Methacholine Chloride 75-87 PCNA clamp associated factor Homo sapiens 108-111 2009789-0 1991 Effects of PAF antagonist, BN52021, on the PAF-, methacholine-, and allergen-induced bronchoconstriction in asthmatic children. Methacholine Chloride 49-61 PCNA clamp associated factor Homo sapiens 11-14 2005318-3 1991 There was a significant correlation between the baseline plasma PAF levels and the degree of bronchial hyperresponsiveness to methacholine. Methacholine Chloride 126-138 PCNA clamp associated factor Homo sapiens 64-67 2209152-6 1990 Asthmatics had increased airway responsiveness to methacholine at two hours post-PAF, which did not persist. Methacholine Chloride 50-62 PCNA clamp associated factor Homo sapiens 81-84 3030311-3 1987 In the functional studies, a subthreshold dose of PAF (0.1 microM) significantly reduced the potency of isoproterenol to reverse methacholine or histamine-induced contraction. Methacholine Chloride 129-141 PCNA clamp associated factor Homo sapiens 50-53 2142013-1 1990 We investigated acute bronchoconstriction and changes in airway responsiveness to methacholine following the inhalation of platelet activating factor (PAF) in an open study of 12 non-asthmatic subjects. Methacholine Chloride 82-94 PCNA clamp associated factor Homo sapiens 151-154 2142013-5 1990 Ten subjects showed some increase in airway responsiveness to methacholine 1 or 3 days following PAF. Methacholine Chloride 62-74 PCNA clamp associated factor Homo sapiens 97-100 3288683-4 1988 On the day placebo was received, airway responsiveness to methacholine increased after PAF exposure with the concentration needed to cause a 40% fall in baseline partial expiratory flow rate (PC40), decreasing from 69.2 mg/ml (geometric standard error of the mean, 2.69) to 23.3 mg/ml (2.34) on day 3 (p less than 0.001). Methacholine Chloride 58-70 PCNA clamp associated factor Homo sapiens 87-90 3314611-5 1987 The 8 PAF responders were 5 to 836 times more sensitive to PAF than to methacholine when SGaw was used to assess the airway response. Methacholine Chloride 71-83 PCNA clamp associated factor Homo sapiens 6-9 3314611-11 1987 Finally, PAF sensitized the airways of all normal subjects to methacholine, including the one PAF nonresponder (p less than 0.02), but it did not sensitize the airways of the asthmatic subjects. Methacholine Chloride 62-74 PCNA clamp associated factor Homo sapiens 9-12