PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25594684-5	2015	Intranasal challenge of Cd38-deficient mice with TNF-alpha or IL-13, or the environmental fungus Alternaria alternata, causes significantly attenuated methacholine responsiveness compared with wild-type mice, with comparable airway inflammation.	Methacholine Chloride	151-163	interleukin 13	Mus musculus	62-67	
23921222-10	2013	The OVA-induced AHR in response to methacholine was enhanced by IL-13 in WT mice but not ASK1(-/-) mice.	Methacholine Chloride	35-47	interleukin 13	Mus musculus	64-69	
24133168-7	2013	Upregulation of TNF-alpha, TGF-beta, and chemokines, as well as increased collagen deposition and airway hyperreactivity to methacholine were all clearly sensitive to IL-13-PE.	Methacholine Chloride	124-136	interleukin 13	Mus musculus	167-172	
25132819-11	2014	But mice treated with IL-13 and GGsTop show attenuation of methacholine-stimulated airway hyper-reactivity, inhibition of Muc5ac and Muc5b gene induction, decreased airway epithelial cell mucous accumulation and a fourfold increase in LLF glutathione content compared to mice treated with IL-13 alone.	Methacholine Chloride	59-71	interleukin 13	Mus musculus	22-27	
19354064-4	2009	METHODS: The BHR to methacholine induced by IL-13 or ovalbumin was determined in BALB/c mice, and the provocation concentration of methacholine that caused an increase in enhanced pause in expiration of 200% (PC200) was calculated.	Methacholine Chloride	20-32	interleukin 13	Mus musculus	44-49	
21951583-5	2011	3 In naive mice, responsiveness to MCh was significantly increased by the combination of IL-1beta and TNF-alpha, IL-13 alone or in combination with IL-1beta, but not by treatment with IL-1beta or TNF-alpha alone.	Methacholine Chloride	35-38	interleukin 13	Mus musculus	113-118	
19237298-5	2009	Pulmonary function tests showed a significant increase in methacholine-induced airway hyperreactivity in OVA/OVA and IL-13-treated mice as compared with controls.	Methacholine Chloride	58-70	interleukin 13	Mus musculus	117-122	
16891391-6	2006	Changes in methacholine-induced R(L) were significantly greater in the WT than in the CD38KO mice following intranasal IL-13 challenges.	Methacholine Chloride	11-23	interleukin 13	Mus musculus	119-124	
16891391-7	2006	Airway reactivity after IL-13 exposure, as measured by the slope of the methacholine dose-response curve, was significantly higher in the WT than in the CD38KO mice.	Methacholine Chloride	72-84	interleukin 13	Mus musculus	24-29	
12789240-9	2003	Moreover, goblet cell metaplasia and airway responsiveness to methacholine could be reduced significantly by the IL-4/IL-13 inhibitor.	Methacholine Chloride	62-74	interleukin 13	Mus musculus	118-123