PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8839225-0 1995 Protective effect of the nitrate ester ITF 296 against methacholine-induced myocardial ischemia in the anesthetized rat. Methacholine Chloride 55-67 trefoil factor 3 Rattus norvegicus 39-42 8839225-1 1995 The activity of ITF 296 against methacholine-induced myocardial ischemia was investigated in anesthetized rats in comparison with the organic nitrates nitroglycerin (NTG) and isosorbide dinitrate (ISDN), the K(+)-channel openers nicorandil and cromakalim, the Ca(2+)-channel blocker amlodipine, and the vasodilator dipyridamole. Methacholine Chloride 32-44 trefoil factor 3 Rattus norvegicus 16-19 8839225-3 1995 boluses, ITF 296 (0.1-100 micrograms/kg) dose-dependently prevented methacholine-induced ST-segment elevation without affecting mean arterial blood pressure or heart rate to a significant extent. Methacholine Chloride 68-80 trefoil factor 3 Rattus norvegicus 9-12