PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28919040-9	2017	CYP3A4 AA epoxygenase inhibition by biguanides thus demonstrates convergence between eicosanoid activity in mitochondria and biguanide action in cancer, opening a new avenue for cancer drug discovery.	Biguanides	36-46	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6	
28919040-5	2017	Metformin bound to the active-site heme of CYP3A4 in a co-crystal structure, establishing CYP3A4 as a biguanide target.	Biguanides	102-111	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	43-49	
28919040-9	2017	CYP3A4 AA epoxygenase inhibition by biguanides thus demonstrates convergence between eicosanoid activity in mitochondria and biguanide action in cancer, opening a new avenue for cancer drug discovery.	Biguanides	36-45	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6	
28919040-5	2017	Metformin bound to the active-site heme of CYP3A4 in a co-crystal structure, establishing CYP3A4 as a biguanide target.	Biguanides	102-111	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	90-96	
16988011-2	2006	In this study, we showed in primary human hepatocytes that: 1) 5"-phosphoribosyl-5-aminoimidazol-4-carboxamide 1-beta-d-ribofuranoside and the biguanide metformin, known activators of AMPK, dose-dependently increase the expression of CYP2B6 and CYP3A4 to an extent similar to that of PB.	Biguanides	143-152	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	245-251