PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27984722-5	2016	Biguanide-induced inactivation of mTORC1 subsequently inhibits growth through transcriptional induction of ACAD10.	Biguanides	0-9	CREB regulated transcription coactivator 1	Mus musculus	34-40	
30244971-4	2018	The mTORC1/4E-BP axis regulates aspartate, asparagine, and serine synthesis by modulating mRNA translation, while ablation of 4E-BP1/2 substantially decreases sensitivity of breast cancer and melanoma cells to KI/biguanide combinations.	Biguanides	213-222	CREB regulated transcription coactivator 1	Mus musculus	4-10	
22861817-1	2013	BACKGROUND: Recent evidence indicates that metformin, a biguanide used as first-line treatment for type 2 diabetes, prevents the conversion of carcinogen-induced oral dysplasias into head and neck squamous cell carcinomas (HNSCC), most likely by inhibiting mammalian target of rapamycin complex 1 (mTORC1) oncogenic signaling.	Biguanides	56-65	CREB regulated transcription coactivator 1	Mus musculus	298-304	
20444419-3	2010	It is thought that agents that increase the cellular AMP/ATP ratio, such as the antidiabetic biguanides metformin and phenformin, inhibit mTORC1 through AMPK activation of TSC1/2-dependent or -independent mechanisms.	Biguanides	93-103	CREB regulated transcription coactivator 1	Mus musculus	138-144	
20444419-4	2010	Unexpectedly, we found that biguanides inhibit mTORC1 signaling, not only in the absence of TSC1/2 but also in the absence of AMPK.	Biguanides	28-38	CREB regulated transcription coactivator 1	Mus musculus	47-53	
20444419-6	2010	We found that the ability of biguanides to inhibit mTORC1 activation and signaling is, instead, dependent on the Rag GTPases.	Biguanides	29-39	CREB regulated transcription coactivator 1	Mus musculus	51-57