PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30918838-10	2019	Recently, drugs belonging to the biguanide class (including metformin) were reported to selectively inhibit CLIC1 activity in CSCs, impairing their viability and invasiveness, but sparing normal stem cells, thus representing potential novel antitumor drugs with a safe toxicological profile.	Biguanides	33-42	chloride intracellular channel 1	Homo sapiens	108-113	
30186163-0	2018	Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability.	Biguanides	58-67	chloride intracellular channel 1	Homo sapiens	14-46	
30186163-0	2018	Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability.	Biguanides	58-67	chloride intracellular channel 1	Homo sapiens	48-53	
30186163-7	2018	All biguanides inhibited CLIC1-mediated ion current, showing the same potency observed in the antiproliferative effects, with the exception of proguanil which was ineffective.	Biguanides	4-14	chloride intracellular channel 1	Homo sapiens	25-30	
30186163-10	2018	In conclusion, the inhibition of CLIC1 activity represents a biguanide class-effect to impair GSC viability, invasiveness, and self-renewal, although dissimilarities among different drugs were observed as far as potency, efficacy and selectivity as CLIC1 inhibitors.	Biguanides	61-70	chloride intracellular channel 1	Homo sapiens	33-38