PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29378206-8 2018 Consistent with these results, PSRC1 overexpression in apoE-/- mice decreased the plasma levels of TC, TG, LDL-C, TNF-alpha, IL-1beta and IL-6, increased the plasma HDL-C levels and improved HDL function. Technetium 99-101 apolipoprotein E Mus musculus 55-59 30526612-10 2018 RESULTS: The metabolic parameters such as total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and triglycerides (TG) levels were lower in ApoE-/-HD + CoQ10 mice than in ApoE-/- HD mice. Technetium 61-63 apolipoprotein E Mus musculus 155-159 30402125-3 2018 In this study, LHRD treatment significantly diminished total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels in apolipoprotein E gene-knockout (ApoE-/-) mice fed with high fat and high cholesterol diet (western diet). Technetium 74-76 apolipoprotein E Mus musculus 156-172 22340159-13 2011 RESULTS: Compared with control mice, apoE(-/-) mice showed increased plasma levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL), decreased high density lipoprotein (HDL), increased aortic plaque size, destroyed ultra-structure of aortic tissue, and increased expression of GRP78 and caspase-12 proteins. Technetium 105-107 apolipoprotein E Mus musculus 37-41 28177681-5 2017 ApoE-/- mice had significantly more atherosclerosis in the aortic root together with increased aortic ROS production, body mass, plasma triglyceride (TG) and total cholesterol (TC) concentration, decreased aortic eNOS expression, and plasma NO concentration. Technetium 177-179 apolipoprotein E Mus musculus 0-4 25864530-6 2015 RESULTS: In vivo [(99m)Tc]-AP39-SPECT imaging of apoE-/- mice demonstrated a significant signal activity in the plaque-ridden thoracic aorta (52.236 +- 40.646 cpm/cm3) that co-localized with the aortic arch and the supra-aortic arteries in MRI scans. Technetium 23-25 apolipoprotein E Mus musculus 49-53 29215758-6 2017 ApoE/Plin5 double knockout (ApoE-/- Plin5-/- ) exacerbated severer atherogenesis, accompanied with significantly disturbed plasma metabolic profiles, such as elevated triglyceride (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) levels and reduced high-density lipoprotein cholesterol (HDLC) contents. Technetium 205-207 apolipoprotein E Mus musculus 0-4 28668302-9 2017 In APOE-/- mice fed a high-fat diet (HFD) for 16weeks, serum lipid profiles (FFAs, TG, TC) and blood glucose levels were significantly increased compared with mice fed a normal diet. Technetium 87-89 apolipoprotein E Mus musculus 3-7 28615707-0 2017 99mTc-labeled bevacizumab for detecting atherosclerotic plaque linked to plaque neovascularization and monitoring antiangiogenic effects of atorvastatin treatment in ApoE-/- mice. Technetium 0-5 apolipoprotein E Mus musculus 166-170 27619241-5 2016 ApoE knock out mice with high fat diet-induced atherosclerosis were scanned via (99m)Tc-GNPs-Annexin V SPECT/CT. Technetium 85-87 apolipoprotein E Mus musculus 0-4 26764329-10 2016 In addition, serum concentrations of TC and TGs in ApoE-KO mice were significantly higher than those in control mice at 12 and 24 wk. Technetium 37-39 apolipoprotein E Mus musculus 51-55 26764329-11 2016 Treatment with AGE significantly suppressed the increases in serum concentrations of TC and TGs in ApoE-KO mice by 21% (P < 0.05) and 19% (P < 0.05) at 24 wk, respectively, and reduced the relative abundance of CD11b(+) cells in ApoE-KO mice by 24% (P < 0.05) at 12 wk. Technetium 85-87 apolipoprotein E Mus musculus 99-103 26955687-12 2016 Levels of TC, TG, and LDL-C increased in 12-week-old apoE(-/-) mice (P < 0.05). Technetium 10-12 apolipoprotein E Mus musculus 53-57 26955687-13 2016 Levels of TC, TG, LDL-C, and HDL-C increased in 16-week-old apoE(-/-) mice (P < 0.05, P < 0.01). Technetium 10-12 apolipoprotein E Mus musculus 60-64 24325064-9 2013 RESULTS: Typical pathological changes of simple fatty liver were manifested in the ApoE(-/-) hyperlipidemia group, TC, TG, and LDL-C increased, the macrophage ratio increased, the expression level of macrophage surface receptor CD206 decreased, showing statistical difference when compared with the ApoE(-/-) common food group (P < 0.01, P < 0.05). Technetium 115-117 apolipoprotein E Mus musculus 83-87 20646585-9 2010 In apoE(-/-) groups (both L-NAME and NS groups), the plasma concentrations of total TC and TG were higher than those of WT groups (P < 0.05). Technetium 84-86 apolipoprotein E Mus musculus 3-7 20835264-6 2010 RESULTS: ApoE-/- mice fed a "Western-style diet" showed an significant age-dependent increase in total cholesterol (TC), LV wall thickness, myocardial cell diameter and LV collagen content (P<0.05). Technetium 116-118 apolipoprotein E Mus musculus 9-13 20734503-17 2004 developed a (99m)Tc-labeled polyclonal antibody F(ab")2 fragment against RAGE and further demonstrated that uptake of the fragment in the atherosclerotic plaques could be visualized with planar gamma imaging in a nondiabetic apolipoprotein E-null (ApoE(-/-)) mouse model (2). Technetium 17-19 apolipoprotein E Mus musculus 248-252 35337573-6 2022 Dietary PSE intervention obviously alleviated the lipid metabolism disorder in ApoE-/- mice by reducing the serum TC and LDL-C contents and increasing the HDL-C content. Technetium 114-116 apolipoprotein E Mus musculus 79-83 18288358-13 2008 The serum TC, TG, LDL-C and HDL-C contents in apoE(-/-) mice aged from 14-day old to 3-month old were higher than those in age-matched WT mice. Technetium 10-12 apolipoprotein E Mus musculus 46-50 17531457-7 2008 ApoE-/- mice, with increased TC and TG concentrations, had higher systemic (P<.05) and retinal (P<.01) levels of lipid peroxidation than wild-type strains. Technetium 29-31 apolipoprotein E Mus musculus 0-4 12588770-7 2003 However, treatment of the cells with beta-DX resulted in all 3 exogenously derived apoE isoforms" reducing TC and EC contents significantly. Technetium 107-109 apolipoprotein E Mus musculus 83-87 34730924-4 2021 After being fed with a high-fat diet, the ApoE knockout mice developed pro-atherogenic lipid profiles with elevated total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C). Technetium 135-137 apolipoprotein E Mus musculus 42-46 34409103-9 2021 Serum levels of TG, TC, and LDL-c were lower in ApoE-/- HD+S mice than in ApoE-/- HD mice. Technetium 20-22 apolipoprotein E Mus musculus 48-52 34409103-9 2021 Serum levels of TG, TC, and LDL-c were lower in ApoE-/- HD+S mice than in ApoE-/- HD mice. Technetium 20-22 apolipoprotein E Mus musculus 74-78 31731717-6 2019 Additionally, after combined therapy with simvastatin and lunasin for four weeks, ApoE-/- mice had significantly lower PCSK9 and higher LDLR levels in hepatic tissues and remarkably reduced plasma concentrations of total cholesterol (TC) and LDL-C, as compared to each monotherapy. Technetium 234-236 apolipoprotein E Mus musculus 82-86 31210194-3 2019 Here, we found that the serum LDL-C, TG and TC levels were elevated and the HDL-C level was decreased in HFD-fed ApoE-/- mice. Technetium 44-46 apolipoprotein E Mus musculus 113-117 32623702-11 2022 ApoE-/- mice treated with CIH had increased TG and TC levels (all P<0.01) and atherosclerotic plaque. Technetium 51-53 apolipoprotein E Mus musculus 0-4 31144159-8 2020 RESULTS: ApoE-/- mice fed with a high-fat diet had notable atherosclerosis lesions, with reduced ABCA1, LXR-alpha and IL-10 levels (all P<0.01), elevated PCSK9, TNF-alpha and IL-6 expression, and increased TC and LDL-C contents (all P<0.01). Technetium 209-211 apolipoprotein E Mus musculus 9-13