PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21881044-3	2011	Here, as one remarkable example, studies using a novel and highly selective pharmacologic inhibitor of the spleen tyrosine kinase Syk [PRT060318; 2-((1R,2S)-2-aminocyclohexylamino)-4-(m-tolylamino)pyrimidine-5-carboxamide] coupled with genetic experiments, demonstrate that Syk inhibition ameliorates both the acute and chronic responses to vascular injury without affecting hemostasis.	2-(2-aminocyclohexylamino)-4-(m-tolylamino)pyrimidine-5-carboxamide	135-144	spleen tyrosine kinase	Mus musculus	130-133	
21881044-3	2011	Here, as one remarkable example, studies using a novel and highly selective pharmacologic inhibitor of the spleen tyrosine kinase Syk [PRT060318; 2-((1R,2S)-2-aminocyclohexylamino)-4-(m-tolylamino)pyrimidine-5-carboxamide] coupled with genetic experiments, demonstrate that Syk inhibition ameliorates both the acute and chronic responses to vascular injury without affecting hemostasis.	2-(2-aminocyclohexylamino)-4-(m-tolylamino)pyrimidine-5-carboxamide	135-144	spleen tyrosine kinase	Mus musculus	274-277	
21088136-0	2011	PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model.	2-(2-aminocyclohexylamino)-4-(m-tolylamino)pyrimidine-5-carboxamide	0-10	spleen tyrosine kinase	Mus musculus	20-23	
21088136-3	2011	We tested PRT-060318 (PRT318), a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment.	2-(2-aminocyclohexylamino)-4-(m-tolylamino)pyrimidine-5-carboxamide	10-20	spleen tyrosine kinase	Mus musculus	82-85	
21088136-3	2011	We tested PRT-060318 (PRT318), a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment.	2-(2-aminocyclohexylamino)-4-(m-tolylamino)pyrimidine-5-carboxamide	22-28	spleen tyrosine kinase	Mus musculus	82-85	
21088136-9	2011	The Syk inhibitor PRT318 thus prevented both HIT immune complex-induced thrombocytopenia and thrombosis in vivo, demonstrating its activity in HIT.	2-(2-aminocyclohexylamino)-4-(m-tolylamino)pyrimidine-5-carboxamide	18-24	spleen tyrosine kinase	Mus musculus	4-7