PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27718184-3	2017	Focused exploration of structure-activity relationships in the imidazoquinolines has led to the identification of several novel human TLR8-specific agonists.	imidazoquinolines	63-80	toll like receptor 8	Homo sapiens	134-138	
28582454-1	2017	The effects of imidazoquinolines on TLR8.	imidazoquinolines	15-32	toll like receptor 8	Homo sapiens	36-40	
28582454-2	2017	Imidazoquinolines are powerful immunostimulants (IMMS) that function through Toll-like receptors, particularly TLR7 and TLR8.	imidazoquinolines	0-17	toll like receptor 8	Homo sapiens	120-124	
26274907-2	2015	In contrast to most TLR agonists (TLRA), TLR8 agonists such as imidazoquinolines (IMQs) induce adult-level Th1-polarizing cytokine production from human neonatal cord blood monocytes and are candidate early life adjuvants.	imidazoquinolines	63-80	toll like receptor 8	Homo sapiens	41-45	
24441505-3	2014	RECENT FINDINGS: Particular attention has been focused upon Toll-like receptor (TLR) agonists, including imidazoquinolines, which can trigger TLR 7 and TLR 8, and cytosine-phosphate-guanine (CpG) oligodeoxynucleotides, which activate TLR 9-expressing cells.	imidazoquinolines	105-122	toll like receptor 8	Homo sapiens	152-157	
17932028-2	2007	TLR7 and TLR8 sense single-stranded RNA from viruses or host ribonucleoproteins and synthetic imidazoquinolines such as R848, whereas TLR9 senses unmethylated CpG motifs in viral and bacterial DNA and in host DNA.	imidazoquinolines	94-111	toll like receptor 8	Homo sapiens	9-13	
23483986-4	2013	We characterized the in vitro immuno-stimulatory activities of a novel benzazepine TLR8 agonist, VTX-294, in comparison to imidazoquinolines that activate TLR8 (R-848; (TLR7/8) CL075; (TLR8/7)), with respect to activation of human newborn and adult leukocytes.	imidazoquinolines	123-140	toll like receptor 8	Homo sapiens	155-159	
23483986-4	2013	We characterized the in vitro immuno-stimulatory activities of a novel benzazepine TLR8 agonist, VTX-294, in comparison to imidazoquinolines that activate TLR8 (R-848; (TLR7/8) CL075; (TLR8/7)), with respect to activation of human newborn and adult leukocytes.	imidazoquinolines	123-140	toll like receptor 8	Homo sapiens	155-159	
22521247-4	2012	TLR8 agonists, including imidazoquinolines (IMQs), such as the small synthetic 3M-002, induce adult-level TNF from neonatal monocytes, but the scope and mechanisms of IMQ-induced activation of neonatal monocytes and monocyte-derived dendritic cells (MoDCs) have not been reported.	imidazoquinolines	25-42	toll like receptor 8	Homo sapiens	0-4	
19234187-4	2009	Demonstrating that TLR7 and TLR8 are expressed on human LC, we hypothesized that imidazoquinolines would activate LC exposed to HPV16, leading to the induction of an HPV16-specific cell-mediated immune response.	imidazoquinolines	81-98	toll like receptor 8	Homo sapiens	28-32	
18031250-3	2007	Mechanisms underlying the remarkable efficacy of TLR8 agonists may include: (i) particularly robust activation of intracellular signalling cascades culminating in nuclear translocation of NF-kappaB (nuclear factor kappaB), (ii) activation of BTK (Bruton"s tyrosine kinase), and (iii) the ability of some imidazoquinolines to induce TLR-independent effects via antagonism of adenosine receptors.	imidazoquinolines	304-321	toll like receptor 8	Homo sapiens	49-53	
17114492-0	2006	Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines.	imidazoquinolines	77-94	toll like receptor 8	Homo sapiens	69-73	
17082568-1	2006	Synthetic immune response modifiers (IRM) such as imidazoquinolines can selectively activate human TLR7 or TLR8.	imidazoquinolines	50-67	toll like receptor 8	Homo sapiens	107-111