PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23483986-4 2013 We characterized the in vitro immuno-stimulatory activities of a novel benzazepine TLR8 agonist, VTX-294, in comparison to imidazoquinolines that activate TLR8 (R-848; (TLR7/8) CL075; (TLR8/7)), with respect to activation of human newborn and adult leukocytes. imidazoquinolines 123-140 toll like receptor 8 Homo sapiens 155-159 28582454-1 2017 The effects of imidazoquinolines on TLR8. imidazoquinolines 15-32 toll like receptor 8 Homo sapiens 36-40 28582454-2 2017 Imidazoquinolines are powerful immunostimulants (IMMS) that function through Toll-like receptors, particularly TLR7 and TLR8. imidazoquinolines 0-17 toll like receptor 8 Homo sapiens 120-124 26274907-2 2015 In contrast to most TLR agonists (TLRA), TLR8 agonists such as imidazoquinolines (IMQs) induce adult-level Th1-polarizing cytokine production from human neonatal cord blood monocytes and are candidate early life adjuvants. imidazoquinolines 63-80 toll like receptor 8 Homo sapiens 41-45 27718184-3 2017 Focused exploration of structure-activity relationships in the imidazoquinolines has led to the identification of several novel human TLR8-specific agonists. imidazoquinolines 63-80 toll like receptor 8 Homo sapiens 134-138 24441505-3 2014 RECENT FINDINGS: Particular attention has been focused upon Toll-like receptor (TLR) agonists, including imidazoquinolines, which can trigger TLR 7 and TLR 8, and cytosine-phosphate-guanine (CpG) oligodeoxynucleotides, which activate TLR 9-expressing cells. imidazoquinolines 105-122 toll like receptor 8 Homo sapiens 152-157 23483986-4 2013 We characterized the in vitro immuno-stimulatory activities of a novel benzazepine TLR8 agonist, VTX-294, in comparison to imidazoquinolines that activate TLR8 (R-848; (TLR7/8) CL075; (TLR8/7)), with respect to activation of human newborn and adult leukocytes. imidazoquinolines 123-140 toll like receptor 8 Homo sapiens 155-159 18031250-3 2007 Mechanisms underlying the remarkable efficacy of TLR8 agonists may include: (i) particularly robust activation of intracellular signalling cascades culminating in nuclear translocation of NF-kappaB (nuclear factor kappaB), (ii) activation of BTK (Bruton"s tyrosine kinase), and (iii) the ability of some imidazoquinolines to induce TLR-independent effects via antagonism of adenosine receptors. imidazoquinolines 304-321 toll like receptor 8 Homo sapiens 49-53 22521247-4 2012 TLR8 agonists, including imidazoquinolines (IMQs), such as the small synthetic 3M-002, induce adult-level TNF from neonatal monocytes, but the scope and mechanisms of IMQ-induced activation of neonatal monocytes and monocyte-derived dendritic cells (MoDCs) have not been reported. imidazoquinolines 25-42 toll like receptor 8 Homo sapiens 0-4 19234187-4 2009 Demonstrating that TLR7 and TLR8 are expressed on human LC, we hypothesized that imidazoquinolines would activate LC exposed to HPV16, leading to the induction of an HPV16-specific cell-mediated immune response. imidazoquinolines 81-98 toll like receptor 8 Homo sapiens 28-32 17932028-2 2007 TLR7 and TLR8 sense single-stranded RNA from viruses or host ribonucleoproteins and synthetic imidazoquinolines such as R848, whereas TLR9 senses unmethylated CpG motifs in viral and bacterial DNA and in host DNA. imidazoquinolines 94-111 toll like receptor 8 Homo sapiens 9-13 17114492-0 2006 Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines. imidazoquinolines 77-94 toll like receptor 8 Homo sapiens 69-73 17082568-1 2006 Synthetic immune response modifiers (IRM) such as imidazoquinolines can selectively activate human TLR7 or TLR8. imidazoquinolines 50-67 toll like receptor 8 Homo sapiens 107-111