PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31935425-4	2020	In mammalian cells, acetyl-CoA is produced by pyruvate dehydrogenase alpha 1 (PDHA1) translocated into the nucleus in special conditions.	Acetyl Coenzyme A	20-30	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	78-83	
7762627-5	1995	A decline in resting PDHa during 20 min of Ace infusion (0.37 +/- 0.08 vs. 0.16 +/- 0.03 mmol.min-1.kg wet wt-1) coincided with an elevation in the acetyl-CoA-to-free CoA ratio (acetyl-CoA/CoASH; 0.28 +/- 0.04 to 0.73 +/- 0.14).	Acetyl Coenzyme A	148-158	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	21-25	
8238502-3	1993	Resting PDHa was lower after a LCD (0.20 +/- 0.04 vs. 0.69 +/- 0.05 mmol.min-1.kg wet wt-1; P < 0.05) and coincided with a greater intramuscular acetyl-CoA-to-CoASH ratio, acetyl-CoA content, and acetylcarnitine content.	Acetyl Coenzyme A	148-158	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	8-12	
8238502-3	1993	Resting PDHa was lower after a LCD (0.20 +/- 0.04 vs. 0.69 +/- 0.05 mmol.min-1.kg wet wt-1; P < 0.05) and coincided with a greater intramuscular acetyl-CoA-to-CoASH ratio, acetyl-CoA content, and acetylcarnitine content.	Acetyl Coenzyme A	175-185	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	8-12	
8238502-6	1993	Under resting conditions PDHa was influenced by the availability of fat or carbohydrate fuels acting through changes in the acetyl-CoA-to-CoASH ratio.	Acetyl Coenzyme A	124-134	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	25-29	
32641713-6	2020	Oxidized ATM up-regulates GLUT1, PKM2, and PDHa expressions to enhance the uptake of glucose and production of pyruvate rather than lactate products, which facilitates glycolytic flux to mitochondrial pyruvate and citrate, thus resulting in accumulation of cytoplasmic acetyl-CoA instead of the tricarboxylic acid (TCA) cycle by regulating ATP-citrate lyase (ACLY) activity.	Acetyl Coenzyme A	269-279	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	43-47	
34488935-2	2021	Suppression of PDHA1 by PDK1 prevents the conversion of cytoplasmic pyruvate into Acetyl-CoA.	Acetyl Coenzyme A	82-92	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	15-20	
26137220-10	2015	By deleting the cytosolic isoform of IDH (IDH1), the enhanced contribution of glutamine to the lipogenic acetyl-CoA pool during PDHA1 suppression was eliminated, and growth was modestly suppressed.	Acetyl Coenzyme A	105-115	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	128-133	
25152236-1	2014	Pyruvate dehydrogenase E1alpha (PDHA1) is the first component enzyme of the pyruvate dehydrogenase (PDH) complex that transforms pyruvate, via pyruvate decarboxylation, into acetyl-CoA that is subsequently used by both the citric acid cycle and oxidative phosphorylation to generate ATP.	Acetyl Coenzyme A	174-184	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	32-37