PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16226706-4 2005 A key enzyme linking glucose metabolism to lipid synthesis is ATP citrate lyase (ACL), which catalyzes the conversion of citrate to cytosolic acetyl-CoA. Acetyl Coenzyme A 142-152 ATP citrate lyase Homo sapiens 62-79 16226706-4 2005 A key enzyme linking glucose metabolism to lipid synthesis is ATP citrate lyase (ACL), which catalyzes the conversion of citrate to cytosolic acetyl-CoA. Acetyl Coenzyme A 142-152 ATP citrate lyase Homo sapiens 81-84 12079877-1 2002 Mammals metabolize citrate to acetyl-CoA and oxaloacetate via the enzyme, ATP:citrate lyase. Acetyl Coenzyme A 30-40 ATP citrate lyase Homo sapiens 74-91 16007201-5 2005 The net conversion of glucose to lipid is dependent on the ability of cells to produce cytosolic acetyl CoA from mitochondria-derived citrate through the action of ATP citrate lyase (ACL). Acetyl Coenzyme A 97-107 ATP citrate lyase Homo sapiens 164-181 16007201-5 2005 The net conversion of glucose to lipid is dependent on the ability of cells to produce cytosolic acetyl CoA from mitochondria-derived citrate through the action of ATP citrate lyase (ACL). Acetyl Coenzyme A 97-107 ATP citrate lyase Homo sapiens 183-186 15234082-5 2004 The primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis. Acetyl Coenzyme A 239-249 ATP citrate lyase Homo sapiens 124-141 11101469-1 2000 BACKGROUND: (-)-Hydroxycitrate (HCA), a competitive inhibitor of ATP-citrate lyase, should reduce the extramitochondrial acetyl-CoA pool. Acetyl Coenzyme A 121-131 ATP citrate lyase Homo sapiens 65-82 11171136-1 2000 We have characterized the expression of potential acetyl-CoA-generating genes (acetyl-CoA synthetase, pyruvate decarboxylase, acetaldehyde dehydrogenase, plastidic pyruvate dehydrogenase complex and ATP-citrate lyase), and compared these with the expression of acetyl-CoA-metabolizing genes (heteromeric and homomeric acetyl-CoA carboxylase). Acetyl Coenzyme A 50-60 ATP citrate lyase Homo sapiens 199-216 7669753-1 1995 ATP-citrate lyase (CL) catalyzes the conversion of citrate and CoA to oxaloacetate (OA) and acetyl-CoA. Acetyl Coenzyme A 92-102 ATP citrate lyase Homo sapiens 0-17 9693110-4 1998 Consistent with an important role of ATP citrate-lyase in the supply of acetyl-CoA units for lipid synthesis de novo, SB-204990 inhibited cholesterol synthesis and fatty acid synthesis in Hep G2 cells (dose-related inhibition of up to 91% and 82% respectively) and rats (76% and 39% respectively). Acetyl Coenzyme A 72-82 ATP citrate lyase Homo sapiens 37-54 10777536-9 2000 Therefore, SREBPs transcriptionally regulates ACL enzyme activity, which generates the cytosolic acetyl CoA required for both cholesterol and fatty acid synthesis. Acetyl Coenzyme A 97-107 ATP citrate lyase Homo sapiens 46-49 8784456-2 1996 ATP-citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Acetyl Coenzyme A 83-93 ATP citrate lyase Homo sapiens 0-17 1675605-3 1991 Experiments performed with ATP citrate lyase and S-(3,4-dicarboxy-3-hydroxybutyl)-CoA are consistent with citryl-CoA but not with citryl-enzyme being the direct precursor of the products acetyl-CoA and oxaloacetate. Acetyl Coenzyme A 187-197 ATP citrate lyase Homo sapiens 27-44 34155695-1 2021 ATP citrate lyase (ACLY), generating most of the nucleocytosolic acetyl coenzyme A (acetyl-CoA) for histone acetylation, links cell metabolism to epigenetic regulation. Acetyl Coenzyme A 84-94 ATP citrate lyase Homo sapiens 0-17 34635427-2 2021 Acly is a key metabolic enzyme synthesizing acetyl-CoA as the building block of cholesterol and fatty acids. Acetyl Coenzyme A 44-54 ATP citrate lyase Homo sapiens 0-4 34831186-3 2021 In this context, the metabolic enzyme ATP citrate lyase (ACLY), the producer of citrate-derived acetyl-coenzyme A (CoA), plays a critical role in supporting a proinflammatory response. Acetyl Coenzyme A 96-113 ATP citrate lyase Homo sapiens 38-55 34831186-3 2021 In this context, the metabolic enzyme ATP citrate lyase (ACLY), the producer of citrate-derived acetyl-coenzyme A (CoA), plays a critical role in supporting a proinflammatory response. Acetyl Coenzyme A 96-113 ATP citrate lyase Homo sapiens 57-61 34831186-3 2021 In this context, the metabolic enzyme ATP citrate lyase (ACLY), the producer of citrate-derived acetyl-coenzyme A (CoA), plays a critical role in supporting a proinflammatory response. Acetyl Coenzyme A 115-118 ATP citrate lyase Homo sapiens 38-55 34831186-3 2021 In this context, the metabolic enzyme ATP citrate lyase (ACLY), the producer of citrate-derived acetyl-coenzyme A (CoA), plays a critical role in supporting a proinflammatory response. Acetyl Coenzyme A 115-118 ATP citrate lyase Homo sapiens 57-61 34620845-4 2021 Here, we show that ATP-citrate lyase (Acly) is enriched in vesicles and provide Acetyl-Coenzyme-A (Acetyl-CoA) to Atat1. Acetyl Coenzyme A 80-97 ATP citrate lyase Homo sapiens 19-36 34620845-4 2021 Here, we show that ATP-citrate lyase (Acly) is enriched in vesicles and provide Acetyl-Coenzyme-A (Acetyl-CoA) to Atat1. Acetyl Coenzyme A 80-97 ATP citrate lyase Homo sapiens 38-42 34620845-4 2021 Here, we show that ATP-citrate lyase (Acly) is enriched in vesicles and provide Acetyl-Coenzyme-A (Acetyl-CoA) to Atat1. Acetyl Coenzyme A 99-109 ATP citrate lyase Homo sapiens 19-36 34620845-4 2021 Here, we show that ATP-citrate lyase (Acly) is enriched in vesicles and provide Acetyl-Coenzyme-A (Acetyl-CoA) to Atat1. Acetyl Coenzyme A 99-109 ATP citrate lyase Homo sapiens 38-42 34716958-8 2022 In addition, FABP7wt overexpression increased the levels of H3K27ac on the caveolin-1 promoter through controlling the nuclear acetyl-CoA level via the interaction with ACLY. Acetyl Coenzyme A 127-137 ATP citrate lyase Homo sapiens 169-173 34155695-1 2021 ATP citrate lyase (ACLY), generating most of the nucleocytosolic acetyl coenzyme A (acetyl-CoA) for histone acetylation, links cell metabolism to epigenetic regulation. Acetyl Coenzyme A 84-94 ATP citrate lyase Homo sapiens 19-23 34155695-4 2021 In the current study, we found that ACLY was gradually activated during RANKL-induced osteoclast differentiation from bone marrow-derived macrophages (BMMs), both ACLY knock-down and small molecular ACLY inhibitor BMS-303141 significantly decreased nucleocytosolic acetyl-CoA in BMMs and osteoclasts and suppressed osteoclast formation in vitro, BMS-303141 also suppressed osteoclast formation in vivo and prevents OVX-induced bone loss. Acetyl Coenzyme A 265-275 ATP citrate lyase Homo sapiens 36-40 34155695-4 2021 In the current study, we found that ACLY was gradually activated during RANKL-induced osteoclast differentiation from bone marrow-derived macrophages (BMMs), both ACLY knock-down and small molecular ACLY inhibitor BMS-303141 significantly decreased nucleocytosolic acetyl-CoA in BMMs and osteoclasts and suppressed osteoclast formation in vitro, BMS-303141 also suppressed osteoclast formation in vivo and prevents OVX-induced bone loss. Acetyl Coenzyme A 265-275 ATP citrate lyase Homo sapiens 163-167 34573442-5 2021 In addition to playing a central role in generating cytosolic acetyl-CoA for de novo lipogenesis, a growing body of work indicates that ACLY also functions in the nucleus where it contributes to the nutrient-sensitive regulation of nuclear acetyl-CoA availability for histone acetylation in cancer cells. Acetyl Coenzyme A 62-72 ATP citrate lyase Homo sapiens 136-140 34573442-4 2021 ATP citrate lyase (ACLY) is a nucleo-cytoplasmic enzyme that produces acetyl coenzyme A (acetyl-CoA), which is the required acetyl donor for lysine acetylation by HATs. Acetyl Coenzyme A 70-87 ATP citrate lyase Homo sapiens 0-17 34573442-4 2021 ATP citrate lyase (ACLY) is a nucleo-cytoplasmic enzyme that produces acetyl coenzyme A (acetyl-CoA), which is the required acetyl donor for lysine acetylation by HATs. Acetyl Coenzyme A 70-87 ATP citrate lyase Homo sapiens 19-23 34573442-4 2021 ATP citrate lyase (ACLY) is a nucleo-cytoplasmic enzyme that produces acetyl coenzyme A (acetyl-CoA), which is the required acetyl donor for lysine acetylation by HATs. Acetyl Coenzyme A 89-99 ATP citrate lyase Homo sapiens 0-17 34573442-4 2021 ATP citrate lyase (ACLY) is a nucleo-cytoplasmic enzyme that produces acetyl coenzyme A (acetyl-CoA), which is the required acetyl donor for lysine acetylation by HATs. Acetyl Coenzyme A 89-99 ATP citrate lyase Homo sapiens 19-23 34573442-5 2021 In addition to playing a central role in generating cytosolic acetyl-CoA for de novo lipogenesis, a growing body of work indicates that ACLY also functions in the nucleus where it contributes to the nutrient-sensitive regulation of nuclear acetyl-CoA availability for histone acetylation in cancer cells. Acetyl Coenzyme A 240-250 ATP citrate lyase Homo sapiens 136-140 35436171-1 2022 INTRODUCTION: ATP citrate lyase (ACLY) is a key enzyme in cellular metabolism, being the main source of acetyl-Coenzyme A, an important precursor for fatty acid, cholesterol and isoprenoid biosynthesis, and it is also involved in protein acetylation. Acetyl Coenzyme A 104-121 ATP citrate lyase Homo sapiens 14-31 34323067-2 2021 Cytoplasmic citrate flux, mediated by plasma membrane citrate transporter (SLC13A5), mitochondrial citrate carrier (SLC25A1), and ATP-dependent citrate lyase (ACLY), determines the central carbon source for acetyl-CoA required in DNL. Acetyl Coenzyme A 207-217 ATP citrate lyase Homo sapiens 130-157 34323067-2 2021 Cytoplasmic citrate flux, mediated by plasma membrane citrate transporter (SLC13A5), mitochondrial citrate carrier (SLC25A1), and ATP-dependent citrate lyase (ACLY), determines the central carbon source for acetyl-CoA required in DNL. Acetyl Coenzyme A 207-217 ATP citrate lyase Homo sapiens 159-163 34294920-0 2021 Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase. Acetyl Coenzyme A 0-10 ATP citrate lyase Homo sapiens 66-83 34294921-0 2021 Reply to: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase. Acetyl Coenzyme A 10-20 ATP citrate lyase Homo sapiens 76-93 34205414-2 2021 Derived from mitochondrial synthesis and/or carboxylation of alpha-ketoglutarate, it is cleaved by ATP-citrate lyase into acetyl-CoA and oxaloacetate. Acetyl Coenzyme A 122-132 ATP citrate lyase Homo sapiens 99-116 34179312-9 2021 ACLY-encoded ATP citrate lyase is essential to maintain cellular acetyl-CoA levels. Acetyl Coenzyme A 65-75 ATP citrate lyase Homo sapiens 0-4 34179312-9 2021 ACLY-encoded ATP citrate lyase is essential to maintain cellular acetyl-CoA levels. Acetyl Coenzyme A 65-75 ATP citrate lyase Homo sapiens 13-30 34375734-6 2021 A hypothetical model of the oncogenic acetylome was proposed that growing demands for histone acetylation in tumor cells would drive the relocalization of acetyl-CoA to the nucleus, which may contribute to the global deacetylation of mitochondrial proteins to support the nuclear acetyl-CoA pool in an ACLY-dependent manner. Acetyl Coenzyme A 155-165 ATP citrate lyase Homo sapiens 302-306 34375734-6 2021 A hypothetical model of the oncogenic acetylome was proposed that growing demands for histone acetylation in tumor cells would drive the relocalization of acetyl-CoA to the nucleus, which may contribute to the global deacetylation of mitochondrial proteins to support the nuclear acetyl-CoA pool in an ACLY-dependent manner. Acetyl Coenzyme A 280-290 ATP citrate lyase Homo sapiens 302-306 34205266-1 2021 Cancer cells rely on ATP-citrate lyase (Acly)-derived acetyl-CoA for lipid biogenesis and proliferation, marking Acly as a promising therapeutic target. Acetyl Coenzyme A 54-64 ATP citrate lyase Homo sapiens 21-38 34205266-1 2021 Cancer cells rely on ATP-citrate lyase (Acly)-derived acetyl-CoA for lipid biogenesis and proliferation, marking Acly as a promising therapeutic target. Acetyl Coenzyme A 54-64 ATP citrate lyase Homo sapiens 40-44 34205266-1 2021 Cancer cells rely on ATP-citrate lyase (Acly)-derived acetyl-CoA for lipid biogenesis and proliferation, marking Acly as a promising therapeutic target. Acetyl Coenzyme A 54-64 ATP citrate lyase Homo sapiens 113-117 35436171-1 2022 INTRODUCTION: ATP citrate lyase (ACLY) is a key enzyme in cellular metabolism, being the main source of acetyl-Coenzyme A, an important precursor for fatty acid, cholesterol and isoprenoid biosynthesis, and it is also involved in protein acetylation. Acetyl Coenzyme A 104-121 ATP citrate lyase Homo sapiens 33-37 35316657-6 2022 Metabolomic, epigenetic, and transcriptomic analyses linked GLUT3 to mitochondrial glucose oxidation and ACLY-dependent acetyl-CoA generation as a rate-limiting step in the epigenetic regulation of inflammatory gene expression. Acetyl Coenzyme A 120-130 ATP citrate lyase Homo sapiens 105-109 35385700-3 2022 The authors show that GLUT3-mediated glucose import and ACLY-dependent acetyl-CoA generation control histone acetylation and, hence, the epigenetic imprinting of effector gene expression in differentiated effector CD4+ T cells. Acetyl Coenzyme A 71-81 ATP citrate lyase Homo sapiens 56-60 32808657-7 2020 Multiple linear regression revealed that ATP citrate lyase was the only main effect affecting the level of acetyl-CoA. Acetyl Coenzyme A 107-117 ATP citrate lyase Homo sapiens 41-58 35402505-6 2022 To do this, we used genome editing to knock out ATP citrate lyase (ACLY), the enzyme responsible for converting citrate to oxaloacetate and acetyl-CoA in the cytoplasm and nucleus. Acetyl Coenzyme A 140-150 ATP citrate lyase Homo sapiens 48-65 35402505-6 2022 To do this, we used genome editing to knock out ATP citrate lyase (ACLY), the enzyme responsible for converting citrate to oxaloacetate and acetyl-CoA in the cytoplasm and nucleus. Acetyl Coenzyme A 140-150 ATP citrate lyase Homo sapiens 67-71 33679780-5 2021 One of the main enzymes catalyzing cytosolic acetyl-CoA formation is ATP-citrate lyase (ACLY). Acetyl Coenzyme A 45-55 ATP citrate lyase Homo sapiens 69-86 33679780-5 2021 One of the main enzymes catalyzing cytosolic acetyl-CoA formation is ATP-citrate lyase (ACLY). Acetyl Coenzyme A 45-55 ATP citrate lyase Homo sapiens 88-92 33679780-6 2021 In addition to its classical function in the provision of acetyl-CoA for de novo lipogenesis, ACLY contributes to epigenetic regulation through histone acetylation, which is increasingly appreciated. Acetyl Coenzyme A 58-68 ATP citrate lyase Homo sapiens 94-98 35177584-10 2022 FAO increased ACLY expression to promote the synthesis of acetyl-CoA, which was transferred by P300 to accelerate H3K27 acetylation of Nanog promoter. Acetyl Coenzyme A 58-68 ATP citrate lyase Homo sapiens 14-18 131232-5 1976 The normal activity of glucose-6-phosphate dehydrogenase and malate dehydrogenase (decarboxylating) (NADP), which supply NADPH for the reduction of acetyl-CoA to fatty acids, would suggest that the change in lipogenesis is of moderate degree, thereb) affecting only the most rate-limiting enzyme, ATP citrate-lyase. Acetyl Coenzyme A 148-158 ATP citrate lyase Homo sapiens 297-314 32164290-7 2020 In addition, significant correlation was only observed between the ACL activity and the concentration of acetyl-CoA (r = 0.4333). Acetyl Coenzyme A 105-115 ATP citrate lyase Homo sapiens 67-70 32525551-8 2020 This, in turn, up-regulated the expression of an acetyl-CoA producing key enzyme ATP citrate lyase (ACLY) and c-Myc, forming a positive feedback loop between the up-regulation of c-Myc expression, glycolytic shift and increased-histone acetylation. Acetyl Coenzyme A 49-59 ATP citrate lyase Homo sapiens 81-98 32525551-8 2020 This, in turn, up-regulated the expression of an acetyl-CoA producing key enzyme ATP citrate lyase (ACLY) and c-Myc, forming a positive feedback loop between the up-regulation of c-Myc expression, glycolytic shift and increased-histone acetylation. Acetyl Coenzyme A 49-59 ATP citrate lyase Homo sapiens 100-104 32448086-1 2021 ATP citrate lyase (ACLY) is an important enzyme that catalyzes the conversion of citrate to acetyl-CoA in normal cells, facilitating the de novo fatty acid synthesis. Acetyl Coenzyme A 92-102 ATP citrate lyase Homo sapiens 0-17 32448086-1 2021 ATP citrate lyase (ACLY) is an important enzyme that catalyzes the conversion of citrate to acetyl-CoA in normal cells, facilitating the de novo fatty acid synthesis. Acetyl Coenzyme A 92-102 ATP citrate lyase Homo sapiens 19-23 32448086-3 2021 Since ACLY-mediated conversion of citrate to acetyl-CoA constitutes the basis for fatty acid synthesis, ACLY seems to be quite an unexplored and promising therapeutic target for anticancer drug design. Acetyl Coenzyme A 45-55 ATP citrate lyase Homo sapiens 6-10 32849657-9 2020 MICA expression was reduced by inhibitors of mitochondrial function, FCCP and etomoxir e.g., and depended on conversion of citrate to acetyl-CoA and oxaloacetate by ATP citrate lyase, which was also observed in several cancer cell types. Acetyl Coenzyme A 134-144 ATP citrate lyase Homo sapiens 165-182 32420483-2 2020 ATP citrate lyase (ACLY) is a key metabolic enzyme that catalyzes the generation of Acetyl-CoA and is upregulated in cancer cells and required for their growth. Acetyl Coenzyme A 84-94 ATP citrate lyase Homo sapiens 0-17 32420483-2 2020 ATP citrate lyase (ACLY) is a key metabolic enzyme that catalyzes the generation of Acetyl-CoA and is upregulated in cancer cells and required for their growth. Acetyl Coenzyme A 84-94 ATP citrate lyase Homo sapiens 19-23 32420483-7 2020 PI3K and Lyn inhibitors reduce the ACLY enzyme activity, ACLY-mediated Acetyl-CoA synthesis, phospholipid synthesis, histone acetylation and cell growth. Acetyl Coenzyme A 71-81 ATP citrate lyase Homo sapiens 57-61 32420483-8 2020 Thus, PIP2/PIP3 binding and Src tyrosine kinases-mediated stimulation of ACLY links oncogenic pathways to Acetyl-CoA-dependent pro-growth and survival metabolic pathways in cancer cells. Acetyl Coenzyme A 106-116 ATP citrate lyase Homo sapiens 73-77 32242119-0 2020 Author Correction: Molecular basis for acetyl-CoA production by ATP-citrate lyase. Acetyl Coenzyme A 39-49 ATP citrate lyase Homo sapiens 64-81 31830561-2 2020 ACLY, which has been found to be overexpressed in many cancers, converts citrate into acetyl-CoA and OAA. Acetyl Coenzyme A 86-96 ATP citrate lyase Homo sapiens 0-4 31873304-0 2020 Molecular basis for acetyl-CoA production by ATP-citrate lyase. Acetyl Coenzyme A 20-30 ATP citrate lyase Homo sapiens 45-62 31947614-1 2020 The Drosophila melanogaster DmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a metabolic enzyme that from citrate generates glucose-derived Acetyl-CoA, which fuels central biochemical reactions such as the synthesis of fatty acids, cholesterol and acetylcholine, and the acetylation of proteins and histones. Acetyl Coenzyme A 160-170 ATP citrate lyase Homo sapiens 63-80 31947614-1 2020 The Drosophila melanogaster DmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a metabolic enzyme that from citrate generates glucose-derived Acetyl-CoA, which fuels central biochemical reactions such as the synthesis of fatty acids, cholesterol and acetylcholine, and the acetylation of proteins and histones. Acetyl Coenzyme A 160-170 ATP citrate lyase Homo sapiens 82-85 31873304-1 2020 ATP-citrate lyase (ACLY) synthesizes cytosolic acetyl coenzyme A (acetyl-CoA), a fundamental cellular building block. Acetyl Coenzyme A 47-64 ATP citrate lyase Homo sapiens 0-17 31873304-1 2020 ATP-citrate lyase (ACLY) synthesizes cytosolic acetyl coenzyme A (acetyl-CoA), a fundamental cellular building block. Acetyl Coenzyme A 47-64 ATP citrate lyase Homo sapiens 19-23 31873304-1 2020 ATP-citrate lyase (ACLY) synthesizes cytosolic acetyl coenzyme A (acetyl-CoA), a fundamental cellular building block. Acetyl Coenzyme A 66-76 ATP citrate lyase Homo sapiens 0-17 31873304-1 2020 ATP-citrate lyase (ACLY) synthesizes cytosolic acetyl coenzyme A (acetyl-CoA), a fundamental cellular building block. Acetyl Coenzyme A 66-76 ATP citrate lyase Homo sapiens 19-23 31873304-6 2020 ACLY with acetyl-CoA and oxaloacetate products shows the products bound in the ASH domain, with an additional oxaloacetate in the CSH domain, which could function in ACLY autoinhibition. Acetyl Coenzyme A 10-20 ATP citrate lyase Homo sapiens 0-4 31873304-6 2020 ACLY with acetyl-CoA and oxaloacetate products shows the products bound in the ASH domain, with an additional oxaloacetate in the CSH domain, which could function in ACLY autoinhibition. Acetyl Coenzyme A 10-20 ATP citrate lyase Homo sapiens 166-170 30853332-3 2019 ACL is an essential enzyme for generating acetyl-CoA, a key metabolite for the first step in fatty acid synthesis and for histone acetylation. Acetyl Coenzyme A 42-52 ATP citrate lyase Homo sapiens 0-3 31411782-1 2019 ATP-citrate lyase (ACLY) catalyzes production of acetyl-CoA and oxaloacetate from CoA and citrate using ATP. Acetyl Coenzyme A 49-59 ATP citrate lyase Homo sapiens 19-23 31141698-2 2019 ATP-citrate lyase (ACLY) is upregulated in adipocytes in response to carbohydrate consumption and generates acetyl-coenzyme A (CoA) for both lipid synthesis and acetylation reactions. Acetyl Coenzyme A 108-125 ATP citrate lyase Homo sapiens 0-17 31141698-2 2019 ATP-citrate lyase (ACLY) is upregulated in adipocytes in response to carbohydrate consumption and generates acetyl-coenzyme A (CoA) for both lipid synthesis and acetylation reactions. Acetyl Coenzyme A 108-125 ATP citrate lyase Homo sapiens 19-23 31141698-2 2019 ATP-citrate lyase (ACLY) is upregulated in adipocytes in response to carbohydrate consumption and generates acetyl-coenzyme A (CoA) for both lipid synthesis and acetylation reactions. Acetyl Coenzyme A 127-130 ATP citrate lyase Homo sapiens 0-17 31141698-2 2019 ATP-citrate lyase (ACLY) is upregulated in adipocytes in response to carbohydrate consumption and generates acetyl-coenzyme A (CoA) for both lipid synthesis and acetylation reactions. Acetyl Coenzyme A 127-130 ATP citrate lyase Homo sapiens 19-23 30877197-1 2019 ATP-citrate lyase (ACLY) is a major source of nucleocytosolic acetyl-CoA, a fundamental building block of carbon metabolism in eukaryotes. Acetyl Coenzyme A 62-72 ATP citrate lyase Homo sapiens 0-17 30877197-1 2019 ATP-citrate lyase (ACLY) is a major source of nucleocytosolic acetyl-CoA, a fundamental building block of carbon metabolism in eukaryotes. Acetyl Coenzyme A 62-72 ATP citrate lyase Homo sapiens 19-23 30877197-4 2019 To this end, we investigated the role of the uncharacterized ACLY C-terminal citrate synthase homology domain in the mechanism of acetyl-CoA formation. Acetyl Coenzyme A 130-140 ATP citrate lyase Homo sapiens 61-65 30877197-7 2019 Our findings highlight a novel and unique role of the C-terminal citrate synthase homology domain in ACLY function and catalysis, adding to the understanding of the molecular basis for acetyl-CoA synthesis by ACLY. Acetyl Coenzyme A 185-195 ATP citrate lyase Homo sapiens 101-105 30877197-7 2019 Our findings highlight a novel and unique role of the C-terminal citrate synthase homology domain in ACLY function and catalysis, adding to the understanding of the molecular basis for acetyl-CoA synthesis by ACLY. Acetyl Coenzyme A 185-195 ATP citrate lyase Homo sapiens 209-213 30877197-8 2019 This newly discovered means of ACLY regulation has implications for the development of novel ACLY modulators to target acetyl-CoA-dependent cellular processes for potential therapeutic use. Acetyl Coenzyme A 119-129 ATP citrate lyase Homo sapiens 31-35 30877197-8 2019 This newly discovered means of ACLY regulation has implications for the development of novel ACLY modulators to target acetyl-CoA-dependent cellular processes for potential therapeutic use. Acetyl Coenzyme A 119-129 ATP citrate lyase Homo sapiens 93-97 31499095-1 2020 ATP citrate lyase (ACLY) is an important enzyme linking carbohydrate to lipid metabolism by generating acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis. Acetyl Coenzyme A 103-113 ATP citrate lyase Homo sapiens 0-17 31499095-1 2020 ATP citrate lyase (ACLY) is an important enzyme linking carbohydrate to lipid metabolism by generating acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis. Acetyl Coenzyme A 103-113 ATP citrate lyase Homo sapiens 19-23 31150280-2 2019 Here we showed that ATP-citrate lyase (ACL), an enzyme converting citrate to acetyl-CoA, is highly induced in the kidney of overweight or obese patients with CKD and ob/ob BTBR mice. Acetyl Coenzyme A 77-87 ATP citrate lyase Homo sapiens 20-37 31150280-2 2019 Here we showed that ATP-citrate lyase (ACL), an enzyme converting citrate to acetyl-CoA, is highly induced in the kidney of overweight or obese patients with CKD and ob/ob BTBR mice. Acetyl Coenzyme A 77-87 ATP citrate lyase Homo sapiens 39-42 31150280-5 2019 By raising acetyl-CoA concentration ACL promotes H3K9/14 and H3K27 hyperacetylation leading to up-regulation of several rate-limiting lipogenic enzymes and fibrogenic factors. Acetyl Coenzyme A 11-21 ATP citrate lyase Homo sapiens 36-39 31150280-6 2019 On the other hand, the excess acetyl-CoA generated as a result of ACL induction provides the substrate for these lipogenic enzymes to drive de novo lipogenesis leading to ELA, a detrimental event toward renal injury. Acetyl Coenzyme A 30-40 ATP citrate lyase Homo sapiens 66-69 30853332-5 2019 In this study, we found that acetyl-CoA or acetate supplementation was sufficient to rescue cell cycle progression in cultured BN cells treated with an ACL inhibitor or induced for PU.1 expression. Acetyl Coenzyme A 29-39 ATP citrate lyase Homo sapiens 152-155 29929979-3 2018 Hence, we studied chondrocyte ATP-citrate lyase (ACLY), which generates acetyl-CoA from mitochondrial-derived citrate, and modulates acetylation of histones and transcription factors. Acetyl Coenzyme A 72-82 ATP citrate lyase Homo sapiens 30-47 29883801-6 2019 In addition, ACSS2, rather than the well-established ACLY, was the key enzyme that supplies acetyl-CoA in T24R cells through glucose-derived endogenous acetate. Acetyl Coenzyme A 92-102 ATP citrate lyase Homo sapiens 53-57 30626590-5 2019 Pancreas-specific loss of the acetyl-CoA-producing enzyme ATP-citrate lyase (ACLY) accordingly suppresses ADM and tumor formation. Acetyl Coenzyme A 30-40 ATP citrate lyase Homo sapiens 58-75 30626590-5 2019 Pancreas-specific loss of the acetyl-CoA-producing enzyme ATP-citrate lyase (ACLY) accordingly suppresses ADM and tumor formation. Acetyl Coenzyme A 30-40 ATP citrate lyase Homo sapiens 77-81 30626590-9 2019 We identify a key role for the metabolic enzyme ACLY, which produces acetyl-CoA, in pancreatic carcinogenesis. Acetyl Coenzyme A 69-79 ATP citrate lyase Homo sapiens 48-52 30586346-3 2019 RECENT FINDINGS: The liver-specific activation of bempedoic acid inhibits ACLY, a key enzyme linking glucose catabolism to lipogenesis by catalyzing the formation of acetyl-CoA from mitochondrial-derived citrate for de novo synthesis of fatty acids and cholesterol. Acetyl Coenzyme A 166-176 ATP citrate lyase Homo sapiens 74-78 30195238-1 2018 ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous hydrolysis of ATP to ADP and phosphate. Acetyl Coenzyme A 127-137 ATP citrate lyase Homo sapiens 0-17 30195238-1 2018 ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous hydrolysis of ATP to ADP and phosphate. Acetyl Coenzyme A 127-137 ATP citrate lyase Homo sapiens 19-23 30195238-4 2018 Once transported to the cytosol, citrate is here converted by ACLY to acetyl-CoA, an essential biosynthetic precursor for fatty acid synthesis and mevalonate pathway. Acetyl Coenzyme A 70-80 ATP citrate lyase Homo sapiens 62-66 29929979-3 2018 Hence, we studied chondrocyte ATP-citrate lyase (ACLY), which generates acetyl-CoA from mitochondrial-derived citrate, and modulates acetylation of histones and transcription factors. Acetyl Coenzyme A 72-82 ATP citrate lyase Homo sapiens 49-53 29929979-11 2018 Increased ACLY activity in OA chondrocytes increased nucleocytosolic acetyl-CoA, leading to increased matrix catabolism via dysregulated histone and transcription factor acetylation. Acetyl Coenzyme A 69-79 ATP citrate lyase Homo sapiens 10-14 29395431-3 2018 show that acetyl-coenzyme A (acetyl-CoA) generated by ATP citrate lyase (ACL) is utilized to acetylate histone H3 at MyoD regulatory regions, resulting in increased MyoD expression and improved muscle regeneration after injury. Acetyl Coenzyme A 29-39 ATP citrate lyase Homo sapiens 54-71 29674394-5 2018 Genes involved in integrin signaling and cell adhesion were identified as acetyl-CoA-responsive in glioblastoma cells, and we demonstrate that ATP citrate lyase (ACLY)-dependent acetyl-CoA production promotes cell migration and adhesion to the extracellular matrix. Acetyl Coenzyme A 74-84 ATP citrate lyase Homo sapiens 143-160 29674394-5 2018 Genes involved in integrin signaling and cell adhesion were identified as acetyl-CoA-responsive in glioblastoma cells, and we demonstrate that ATP citrate lyase (ACLY)-dependent acetyl-CoA production promotes cell migration and adhesion to the extracellular matrix. Acetyl Coenzyme A 74-84 ATP citrate lyase Homo sapiens 162-166 29674394-5 2018 Genes involved in integrin signaling and cell adhesion were identified as acetyl-CoA-responsive in glioblastoma cells, and we demonstrate that ATP citrate lyase (ACLY)-dependent acetyl-CoA production promotes cell migration and adhesion to the extracellular matrix. Acetyl Coenzyme A 178-188 ATP citrate lyase Homo sapiens 143-160 29674394-5 2018 Genes involved in integrin signaling and cell adhesion were identified as acetyl-CoA-responsive in glioblastoma cells, and we demonstrate that ATP citrate lyase (ACLY)-dependent acetyl-CoA production promotes cell migration and adhesion to the extracellular matrix. Acetyl Coenzyme A 178-188 ATP citrate lyase Homo sapiens 162-166 28993031-3 2017 ATP-citrate lyase (ACL) is the enzyme primarily responsible for the production of extramitochondrial acetyl-CoA and is thus strategically positioned at the intersection of nutrient catabolism and lipid biosynthesis. Acetyl Coenzyme A 101-111 ATP citrate lyase Homo sapiens 0-17 28993031-3 2017 ATP-citrate lyase (ACL) is the enzyme primarily responsible for the production of extramitochondrial acetyl-CoA and is thus strategically positioned at the intersection of nutrient catabolism and lipid biosynthesis. Acetyl Coenzyme A 101-111 ATP citrate lyase Homo sapiens 19-22 28490526-1 2017 The goal of this study was to address the role of ATP-citrate lyase (ACL), an enzyme that converts citrate to acetyl-CoA, in high glucose (HG)-induced histone acetylation and profibrotic gene expression. Acetyl Coenzyme A 110-120 ATP citrate lyase Homo sapiens 50-67 27997879-2 2017 ATP citrate lyase (ACL) plays a critical role in generating cytosolic acetyl CoA, a key building block for de novo fatty acid and cholesterol biosynthesis. Acetyl Coenzyme A 70-80 ATP citrate lyase Homo sapiens 0-17 28689661-7 2017 Thus, the spatial and temporal control of acetyl-CoA production by ACLY participates in the mechanism of DNA repair pathway choice. Acetyl Coenzyme A 42-52 ATP citrate lyase Homo sapiens 67-71 28732204-0 2017 Put Your Mark Where Your Damage Is: Acetyl-CoA Production by ACLY Promotes DNA Repair. Acetyl Coenzyme A 36-46 ATP citrate lyase Homo sapiens 61-65 28732204-2 2017 (2017) describe the importance for nuclear ACLY-mediated production of acetyl-CoA, which promotes histone acetylation, BRCA1 recruitment, and subsequent HR-mediated DNA repair in response to DNA damage, thus drawing a direct link between DNA repair and cellular metabolism. Acetyl Coenzyme A 71-81 ATP citrate lyase Homo sapiens 43-47 28059952-3 2017 RECENT FINDINGS: ACLY is a critical enzyme linking glucose catabolism to lipogenesis by providing acetyl-CoA from mitochondrial citrate for fatty acid and cholesterol biosynthesis. Acetyl Coenzyme A 98-108 ATP citrate lyase Homo sapiens 17-21 28167750-2 2017 In mammalian cells the central precursor for lipid biosynthesis, cytosolic acetyl CoA (Ac-CoA), is produced by ATP-citrate lyase (ACLY) from mitochondria-derived citrate or by acetyl-CoA synthetase short-chain family member 2 (ACSS2) from acetate. Acetyl Coenzyme A 75-85 ATP citrate lyase Homo sapiens 111-128 28167750-2 2017 In mammalian cells the central precursor for lipid biosynthesis, cytosolic acetyl CoA (Ac-CoA), is produced by ATP-citrate lyase (ACLY) from mitochondria-derived citrate or by acetyl-CoA synthetase short-chain family member 2 (ACSS2) from acetate. Acetyl Coenzyme A 75-85 ATP citrate lyase Homo sapiens 130-134 28167750-2 2017 In mammalian cells the central precursor for lipid biosynthesis, cytosolic acetyl CoA (Ac-CoA), is produced by ATP-citrate lyase (ACLY) from mitochondria-derived citrate or by acetyl-CoA synthetase short-chain family member 2 (ACSS2) from acetate. Acetyl Coenzyme A 87-93 ATP citrate lyase Homo sapiens 111-128 28167750-2 2017 In mammalian cells the central precursor for lipid biosynthesis, cytosolic acetyl CoA (Ac-CoA), is produced by ATP-citrate lyase (ACLY) from mitochondria-derived citrate or by acetyl-CoA synthetase short-chain family member 2 (ACSS2) from acetate. Acetyl Coenzyme A 87-93 ATP citrate lyase Homo sapiens 130-134 28167750-3 2017 It has been reported that ACLY is the primary enzyme involved in making cytosolic Ac-CoA in cells with abundant nutrients. Acetyl Coenzyme A 82-88 ATP citrate lyase Homo sapiens 26-30 28129980-1 2017 The enzyme ATP citrate lyase (ACL) catalyzes the formation of cytosolic acetyl CoA, the starting material for de novo lipid and cholesterol biosynthesis. Acetyl Coenzyme A 72-82 ATP citrate lyase Homo sapiens 11-28 28129980-1 2017 The enzyme ATP citrate lyase (ACL) catalyzes the formation of cytosolic acetyl CoA, the starting material for de novo lipid and cholesterol biosynthesis. Acetyl Coenzyme A 72-82 ATP citrate lyase Homo sapiens 30-33 27997879-2 2017 ATP citrate lyase (ACL) plays a critical role in generating cytosolic acetyl CoA, a key building block for de novo fatty acid and cholesterol biosynthesis. Acetyl Coenzyme A 70-80 ATP citrate lyase Homo sapiens 19-22 27088128-7 2016 In contrast, acetyl CoA is primarily synthesized by an alternate enzyme, ATP-citrate lyase, in mammalian cells. Acetyl Coenzyme A 13-23 ATP citrate lyase Homo sapiens 73-90 27760311-6 2016 ACLY-deficient adipocytes accumulate lipid in vivo, exhibit increased acetyl-CoA and malonyl-CoA production from acetate, and display some differences in fatty acid content and synthesis. Acetyl Coenzyme A 70-80 ATP citrate lyase Homo sapiens 0-4 27015560-7 2016 Depletion of mTORC2 but not mTORC1 specifically inhibited the ACL-dependent acetyl-CoA production. Acetyl Coenzyme A 76-86 ATP citrate lyase Homo sapiens 62-65 27015560-8 2016 In the HER2+/PIK3CAmut MDA361, MDA453, BT-474 and T47D cells, depletion of mTORC2 or ACL led to growth inhibition and mitochondrial hyperpolarization, which were partially rescued by an alternate source of acetyl-CoA. Acetyl Coenzyme A 206-216 ATP citrate lyase Homo sapiens 85-88 27015560-10 2016 Moreover, ACL Ser-455 mutants S455E (phosphomimetic) and S455A (non-phosphorylatable) each increased or decreased, respectively, the acetyl-CoA production, mitochondrial homeostasis and survival in ACL-depleted MDA453 cells. Acetyl Coenzyme A 133-143 ATP citrate lyase Homo sapiens 10-13 27015560-11 2016 These studies define a new and rapamycin-resistant mechanism of mTORC2-ACL in lipogenesis and acetyl-CoA biology and provide a rationale for targeting of mTORC1 and mTORC2 in HER2+/PIK3CAmut breast cancer. Acetyl Coenzyme A 94-104 ATP citrate lyase Homo sapiens 71-74 26039450-2 2015 ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes mitochondria-derived citrate into oxaloacetate and acetyl-CoA. Acetyl Coenzyme A 112-122 ATP citrate lyase Homo sapiens 0-17 26025427-1 2015 ATP citrate lyase (ACL) is an enzyme critical to the generation of cytosolic acetyl-CoA in eukaryotes. Acetyl Coenzyme A 77-87 ATP citrate lyase Homo sapiens 0-17 26025427-1 2015 ATP citrate lyase (ACL) is an enzyme critical to the generation of cytosolic acetyl-CoA in eukaryotes. Acetyl Coenzyme A 77-87 ATP citrate lyase Homo sapiens 19-22 26915799-0 2016 Polyamine regulating protein antizyme binds to ATP citrate lyase to accelerate acetyl-CoA production in cancer cells. Acetyl Coenzyme A 79-89 ATP citrate lyase Homo sapiens 47-64 26915799-2 2016 Screening for AZ-binding proteins using a yeast two-hybrid system identified ATP citrate lyase (ACLY), a cytosolic enzyme which catalyzes the production of acetyl-CoA that is used for lipid anabolism or acetylation of cellular components. Acetyl Coenzyme A 156-166 ATP citrate lyase Homo sapiens 77-94 26915799-2 2016 Screening for AZ-binding proteins using a yeast two-hybrid system identified ATP citrate lyase (ACLY), a cytosolic enzyme which catalyzes the production of acetyl-CoA that is used for lipid anabolism or acetylation of cellular components. Acetyl Coenzyme A 156-166 ATP citrate lyase Homo sapiens 96-100 26039450-2 2015 ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes mitochondria-derived citrate into oxaloacetate and acetyl-CoA. Acetyl Coenzyme A 112-122 ATP citrate lyase Homo sapiens 19-22 25701462-1 2015 ATP citrate lyase (ACLY) is responsible for the conversion of cytosolic citrate into acetyl-CoA and oxaloacetate, and the first rate-limiting enzyme involved in de novo lipogenesis. Acetyl Coenzyme A 85-95 ATP citrate lyase Homo sapiens 0-17 26221340-2 2015 ATP citrate lyase (ACLY) is generally recognized as a key enzyme of de novo fatty acid synthesis responsible for generation of oxaloacetate and cytosolic acetyl-CoA. Acetyl Coenzyme A 154-164 ATP citrate lyase Homo sapiens 0-17 26221340-2 2015 ATP citrate lyase (ACLY) is generally recognized as a key enzyme of de novo fatty acid synthesis responsible for generation of oxaloacetate and cytosolic acetyl-CoA. Acetyl Coenzyme A 154-164 ATP citrate lyase Homo sapiens 19-23 25701462-1 2015 ATP citrate lyase (ACLY) is responsible for the conversion of cytosolic citrate into acetyl-CoA and oxaloacetate, and the first rate-limiting enzyme involved in de novo lipogenesis. Acetyl Coenzyme A 85-95 ATP citrate lyase Homo sapiens 19-23 25537655-1 2015 ATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA. Acetyl Coenzyme A 173-183 ATP citrate lyase Homo sapiens 0-17 25537655-1 2015 ATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA. Acetyl Coenzyme A 173-183 ATP citrate lyase Homo sapiens 19-23 23897429-2 2013 We have previously shown that histone acetylation increases during differentiation in a manner dependent on acetyl coenzyme A (acetyl-CoA) production by the enzyme ATP-citrate lyase (ACL). Acetyl Coenzyme A 127-137 ATP citrate lyase Homo sapiens 164-181 25367309-1 2015 ATP citrate lyase (ACLY) is a key enzyme that is involved in de novo lipogenesis by catalyzing conversion of cytosolic citrate into acetyl CoA and oxaloacetate. Acetyl Coenzyme A 132-142 ATP citrate lyase Homo sapiens 0-17 25367309-1 2015 ATP citrate lyase (ACLY) is a key enzyme that is involved in de novo lipogenesis by catalyzing conversion of cytosolic citrate into acetyl CoA and oxaloacetate. Acetyl Coenzyme A 132-142 ATP citrate lyase Homo sapiens 19-23 25367309-2 2015 Up-regulation of ACLY in various types of tumors enhances fatty acid synthesis and supplies excess acetyl CoA for histone acetylation. Acetyl Coenzyme A 99-109 ATP citrate lyase Homo sapiens 17-21 21688263-1 2012 ATP citrate lyase (ACL) catalyzes the conversion of cytosolic citrate to acetyl-CoA and oxaloacetate. Acetyl Coenzyme A 73-83 ATP citrate lyase Homo sapiens 0-17 22718913-1 2012 ATP citrate lyase (ACLY) is a cytosolic enzyme that catalyzes generation of acetyl-CoA, which is a vital building block for fatty acid, cholesterol, and isoprenoid biosynthesis. Acetyl Coenzyme A 76-86 ATP citrate lyase Homo sapiens 0-17 22718913-1 2012 ATP citrate lyase (ACLY) is a cytosolic enzyme that catalyzes generation of acetyl-CoA, which is a vital building block for fatty acid, cholesterol, and isoprenoid biosynthesis. Acetyl Coenzyme A 76-86 ATP citrate lyase Homo sapiens 19-23 22718913-9 2012 Furthermore, ACLY suppression resulted in elevated expression of acyl-CoA synthetase short-chain family member 2 (ACSS2), an enzyme that also produces acetyl-CoA using acetate as a substrate. Acetyl Coenzyme A 151-161 ATP citrate lyase Homo sapiens 13-17 22787121-1 2012 ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl CoA from citrate. Acetyl Coenzyme A 80-90 ATP citrate lyase Homo sapiens 0-17 22787121-1 2012 ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl CoA from citrate. Acetyl Coenzyme A 80-90 ATP citrate lyase Homo sapiens 19-23 22575446-1 2012 ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes generation of acetyl-CoA from citrate. Acetyl Coenzyme A 76-86 ATP citrate lyase Homo sapiens 0-17 22575446-1 2012 ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes generation of acetyl-CoA from citrate. Acetyl Coenzyme A 76-86 ATP citrate lyase Homo sapiens 19-23 21688263-1 2012 ATP citrate lyase (ACL) catalyzes the conversion of cytosolic citrate to acetyl-CoA and oxaloacetate. Acetyl Coenzyme A 73-83 ATP citrate lyase Homo sapiens 19-22 22102020-1 2011 Human ATP-citrate lyase (EC 2.3.3.8) is the cytoplasmic enzyme that catalyzes the production of acetyl-CoA from citrate, CoA and ATP. Acetyl Coenzyme A 96-106 ATP citrate lyase Homo sapiens 6-23 21237280-1 2011 Adenosine triphosphate (ATP) citrate lyase (ACL) is a key enzyme in the production of cytosolic acetyl-CoA, which is crucial for de novo lipid synthesis and histone acetylation in mammalian cells. Acetyl Coenzyme A 96-106 ATP citrate lyase Homo sapiens 0-42 19965590-8 2010 Knockdown of ATP-citrate lyase, which converts citrate to acetyl-CoA, decreased histone acetylation and attenuated glucose induction of CYP7A1 mRNA expression. Acetyl Coenzyme A 58-68 ATP citrate lyase Homo sapiens 13-30 20531298-7 2010 Conversely, the enzyme ATP citrate lyase (ACL), relates energy balance to GCN5, through the control of the nuclear production of acetyl-CoA, the substrate for GCN5"s acetyltransferase activity. Acetyl Coenzyme A 129-139 ATP citrate lyase Homo sapiens 23-40 19286649-2 2009 The ACL-dependent synthesis of acetyl-CoA is thought to be an essential step for the de novo synthesis of fatty acids and cholesterol. Acetyl Coenzyme A 31-41 ATP citrate lyase Homo sapiens 4-7 19968906-4 2010 Nuclear ATP-citrate lyase generates acetyl-CoA, which has been shown to have a role in the activation of specific genes via selective histone acetylation. Acetyl Coenzyme A 36-46 ATP citrate lyase Homo sapiens 8-25 19286649-8 2009 The current assay consists of 1) incubation of ACL enzyme with [(14)C]citrate and other substrates/cofactors CoA, ATP, and Mg(2+), 2) EDTA quench, 3) addition of MicroScint-O, the agent that specifically detects product [(14)C]acetyl-CoA, and 4) detection of signal by TopCount. Acetyl Coenzyme A 227-237 ATP citrate lyase Homo sapiens 47-50 18922930-2 2008 ATP citrate lyase (ACLY) is a key enzyme of de novo fatty acid synthesis responsible for generating cytosolic acetyl-CoA and oxaloacetate. Acetyl Coenzyme A 110-120 ATP citrate lyase Homo sapiens 0-17 18922930-2 2008 ATP citrate lyase (ACLY) is a key enzyme of de novo fatty acid synthesis responsible for generating cytosolic acetyl-CoA and oxaloacetate. Acetyl Coenzyme A 110-120 ATP citrate lyase Homo sapiens 19-23