PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26140605-4	2015	Lysine catabolism generates acetyl-CoA, which is used in p300-dependent LRP6 acetylation.	Acetyl Coenzyme A	28-38	E1A binding protein p300	Homo sapiens	57-61	
23862699-4	2013	Our results show that while p300 and CBP acetylate many common residues on H3 and H4, they do in fact possess very different specificities, and these specificities are dependent on whether histone or acetyl-CoA is limiting.	Acetyl Coenzyme A	200-210	E1A binding protein p300	Homo sapiens	28-32	
25821559-6	2015	Pre-acetylation of p300 by incubation with acetyl-CoA alone reduces p300"s ability to acetylate H3K18 in chromatin.	Acetyl Coenzyme A	43-53	E1A binding protein p300	Homo sapiens	19-23	
25821559-6	2015	Pre-acetylation of p300 by incubation with acetyl-CoA alone reduces p300"s ability to acetylate H3K18 in chromatin.	Acetyl Coenzyme A	43-53	E1A binding protein p300	Homo sapiens	68-72	
24688408-7	2014	CR like HAT-1, CBP, and p300 mediated the acylation of RP utilizing acetyl CoA and propionyl CoA as the substrates.	Acetyl Coenzyme A	68-78	E1A binding protein p300	Homo sapiens	24-28	
25325435-2	2015	We have previously reported that acetyl-CoA levels alter p300 histone acetylation in a site-specific manner in vitro.	Acetyl Coenzyme A	33-43	E1A binding protein p300	Homo sapiens	57-61	
25325435-3	2015	Here, we further investigate how changing acetyl-CoA concentrations alter the histone acetylation pattern by altering p300 specificity.	Acetyl Coenzyme A	42-52	E1A binding protein p300	Homo sapiens	118-122	
23862699-8	2013	With limiting acetyl-CoA, p300 has the highest specificity at H4K16, where specificity is 1018-fold higher than CBP.	Acetyl Coenzyme A	14-24	E1A binding protein p300	Homo sapiens	26-30	
16415879-3	2006	We then examined the biochemical function of purified p300 in the absence of the endogenous factor and other related activities and found, unexpectedly, that p300 has a chromatin-specific, transcriptional repression activity that can be relieved by the addition of acetyl-CoA.	Acetyl Coenzyme A	265-275	E1A binding protein p300	Homo sapiens	158-162	
19086895-4	2009	The p300 specific HAT inhibitor 1 behaves as a noncompetitive inhibitor for both acetyl-CoA and histone, unlike nonspecific HAT inhibitors garcinol and isogarcinol.	Acetyl Coenzyme A	81-91	E1A binding protein p300	Homo sapiens	4-8	
11030335-2	2000	Here, we show that p300 mediates acetyl-CoA-dependent transcription by GAL4-VP16 from a nucleosomal array template, that this involves p300 targeting by GAL4-VP16 and promoter-proximal histone acetylation prior to transcription, and that the affinities of different activators for p300 roughly correlate with corresponding levels of p300-dependent transcription.	Acetyl Coenzyme A	33-43	E1A binding protein p300	Homo sapiens	135-139	
11691934-6	2001	In order to identify residues involved in substrate or acetyl-coenzyme A (acetyl-CoA) recognition, we have introduced 19 different amino acid substitutions in segments that are highly conserved between animal and plant p300/CBP proteins.	Acetyl Coenzyme A	74-84	E1A binding protein p300	Homo sapiens	219-223	
11030335-2	2000	Here, we show that p300 mediates acetyl-CoA-dependent transcription by GAL4-VP16 from a nucleosomal array template, that this involves p300 targeting by GAL4-VP16 and promoter-proximal histone acetylation prior to transcription, and that the affinities of different activators for p300 roughly correlate with corresponding levels of p300-dependent transcription.	Acetyl Coenzyme A	33-43	E1A binding protein p300	Homo sapiens	19-23	
11030335-2	2000	Here, we show that p300 mediates acetyl-CoA-dependent transcription by GAL4-VP16 from a nucleosomal array template, that this involves p300 targeting by GAL4-VP16 and promoter-proximal histone acetylation prior to transcription, and that the affinities of different activators for p300 roughly correlate with corresponding levels of p300-dependent transcription.	Acetyl Coenzyme A	33-43	E1A binding protein p300	Homo sapiens	135-139	
11030335-2	2000	Here, we show that p300 mediates acetyl-CoA-dependent transcription by GAL4-VP16 from a nucleosomal array template, that this involves p300 targeting by GAL4-VP16 and promoter-proximal histone acetylation prior to transcription, and that the affinities of different activators for p300 roughly correlate with corresponding levels of p300-dependent transcription.	Acetyl Coenzyme A	33-43	E1A binding protein p300	Homo sapiens	135-139	
33334880-4	2021	We report that p300 weakly acetylates PCK1, but surprisingly, using several techniques including protein crystallization, mass spectrometry, isothermal titration calorimetry (ITC), saturation-transfer difference nuclear magnetic resonance (STD-NMR) and molecular docking, we found that PCK1 is also able to acetylate itself using acetyl-CoA independently of p300.	Acetyl Coenzyme A	330-340	E1A binding protein p300	Homo sapiens	15-19	
34055630-8	2021	Molecular docking studies reveal that carnosol inhibits p300 HAT activity by blocking the entry of the acetyl-CoA binding pocket of the catalytic domain.	Acetyl Coenzyme A	103-113	E1A binding protein p300	Homo sapiens	56-60	
34055630-9	2021	The superimposition of the docked conformation of the p300 HAT domain in complex with carnosol shows a similar orientation as the p300 structure with acetyl-CoA.	Acetyl Coenzyme A	150-160	E1A binding protein p300	Homo sapiens	54-58	
34055630-9	2021	The superimposition of the docked conformation of the p300 HAT domain in complex with carnosol shows a similar orientation as the p300 structure with acetyl-CoA.	Acetyl Coenzyme A	150-160	E1A binding protein p300	Homo sapiens	130-134	
28953875-6	2017	We present a high resolution (1.95 A) co-crystal structure of a small molecule bound to the catalytic active site of p300 and demonstrate that A-485 competes with acetyl coenzyme A (acetyl-CoA).	Acetyl Coenzyme A	182-192	E1A binding protein p300	Homo sapiens	117-121	
30301423-7	2019	For this reason, the CTB recruits more acetyl-CoA in the active site of p300 compared with CTPB; it leads to activate the acetylation process; hence, CTB may be a best activator than CTPB.	Acetyl Coenzyme A	39-49	E1A binding protein p300	Homo sapiens	72-76	
28630323-6	2017	The structure of the apo-CBP HAT domain is similar to that of acyl-CoA-bound p300 HAT complexes and shows that the acetyl-CoA binding site is stably formed in the absence of cofactor.	Acetyl Coenzyme A	115-125	E1A binding protein p300	Homo sapiens	77-85	
26405201-8	2016	Based on these findings, we propose a local acetyl-CoA production system in which PKM2 and PDC locally supply acetyl-CoA to p300 from abundant PEP for histone acetylation at the gene enhancer, and our data suggest that PKM2 sensitizes AhR-mediated detoxification in actively proliferating cells such as cancer and fetal cells.	Acetyl Coenzyme A	44-54	E1A binding protein p300	Homo sapiens	124-128	
26405201-8	2016	Based on these findings, we propose a local acetyl-CoA production system in which PKM2 and PDC locally supply acetyl-CoA to p300 from abundant PEP for histone acetylation at the gene enhancer, and our data suggest that PKM2 sensitizes AhR-mediated detoxification in actively proliferating cells such as cancer and fetal cells.	Acetyl Coenzyme A	110-120	E1A binding protein p300	Homo sapiens	124-128