PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7929613-3 1994 In cells in which glucose oxidation is switched off during starvation, fatty acids are used as fuel, and acetyl CoA and NADH formed by beta-oxidation promote phosphorylation of PDH complex by activation of PDH kinase. Acetyl Coenzyme A 105-115 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 177-180 7929613-3 1994 In cells in which glucose oxidation is switched off during starvation, fatty acids are used as fuel, and acetyl CoA and NADH formed by beta-oxidation promote phosphorylation of PDH complex by activation of PDH kinase. Acetyl Coenzyme A 105-115 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 206-209 2249846-1 1990 The pyruvate dehydrogenase (PDH) complex converts pyruvate to acetyl CoA, an essential step in aerobic glucose metabolism. Acetyl Coenzyme A 62-72 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 4-26 2249846-1 1990 The pyruvate dehydrogenase (PDH) complex converts pyruvate to acetyl CoA, an essential step in aerobic glucose metabolism. Acetyl Coenzyme A 62-72 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 28-31 33809182-6 2021 In addition, BACH1 suppresses activity of pyruvate dehydrogenase (PDH), a key enzyme that converts pyruvate to acetyl-CoA for the citric acid (TCA) cycle through transcriptional activation of pyruvate dehydrogenase kinase (PDK). Acetyl Coenzyme A 111-121 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 42-64 33809182-6 2021 In addition, BACH1 suppresses activity of pyruvate dehydrogenase (PDH), a key enzyme that converts pyruvate to acetyl-CoA for the citric acid (TCA) cycle through transcriptional activation of pyruvate dehydrogenase kinase (PDK). Acetyl Coenzyme A 111-121 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 66-69 35315437-2 2022 The pyruvate dehydrogenase (PDH) complex converts pyruvate to acetyl-coenzyme A in mitochondria, thereby linking glycolysis to the ricarboxylic acid cycle. Acetyl Coenzyme A 62-79 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 4-26 35315437-2 2022 The pyruvate dehydrogenase (PDH) complex converts pyruvate to acetyl-coenzyme A in mitochondria, thereby linking glycolysis to the ricarboxylic acid cycle. Acetyl Coenzyme A 62-79 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 28-31 33725483-3 2021 Here, we report that Rheb regulates mitochondrial tricarboxylic acid cycle flux of acetyl-CoA by activating pyruvate dehydrogenase (PDH) to increase ATP production. Acetyl Coenzyme A 83-93 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 108-130 33725483-3 2021 Here, we report that Rheb regulates mitochondrial tricarboxylic acid cycle flux of acetyl-CoA by activating pyruvate dehydrogenase (PDH) to increase ATP production. Acetyl Coenzyme A 83-93 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 132-135 33675030-4 2022 Activation of PDK suppresses the conversion of pyruvate to acetyl-coenzyme A (acetyl-CoA) through the inactivation of PDH, which allows the cumulus cells to supply sufficient amounts of pyruvate, lactate, and nicotinamide adenine dinucleotide phosphate (NADPH) to the oocytes. Acetyl Coenzyme A 59-76 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 118-121 33675030-4 2022 Activation of PDK suppresses the conversion of pyruvate to acetyl-coenzyme A (acetyl-CoA) through the inactivation of PDH, which allows the cumulus cells to supply sufficient amounts of pyruvate, lactate, and nicotinamide adenine dinucleotide phosphate (NADPH) to the oocytes. Acetyl Coenzyme A 78-88 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 118-121 31958319-8 2020 Acetyl-CoA, the product of PDH activity, was significantly reduced by hypoxia treatment with (P)RR siRNA. Acetyl Coenzyme A 0-10 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 27-30 31582221-2 2019 Pyruvate dehydrogenase (PDH) is a metabolic enzyme that converts pyruvate into acetyl-CoA, connecting glycolysis to the TCA cycle, thus regulating cellular energy metabolism. Acetyl Coenzyme A 79-89 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 0-22 31582221-2 2019 Pyruvate dehydrogenase (PDH) is a metabolic enzyme that converts pyruvate into acetyl-CoA, connecting glycolysis to the TCA cycle, thus regulating cellular energy metabolism. Acetyl Coenzyme A 79-89 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 24-27 31582221-3 2019 PDH is involved in multiple cellular processes, such as glucose metabolism, fatty acid synthesis, and protein acetylation, all of which are mediated by acetyl-CoA. Acetyl Coenzyme A 152-162 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 0-3 31623369-6 2019 To understand SA-induced reduction in ATP production, we investigated the electron transfer chains (ETC) and pyruvate dehydrogenase kinase (PDK) activity, which prevents the transfer of acetyl-CoA to the TCA (tricarboxylic acid) cycle by inhibiting PDH (pyruvate dehydrogenase) activity. Acetyl Coenzyme A 186-196 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 249-252 31623369-6 2019 To understand SA-induced reduction in ATP production, we investigated the electron transfer chains (ETC) and pyruvate dehydrogenase kinase (PDK) activity, which prevents the transfer of acetyl-CoA to the TCA (tricarboxylic acid) cycle by inhibiting PDH (pyruvate dehydrogenase) activity. Acetyl Coenzyme A 186-196 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 109-131 30881593-1 2019 Pyruvate dehydrogenase (PDH) complex, a multienzyme complex at the nexus of glycolytic and Krebs cycles, provides acetyl-CoA to the Krebs cycle and NADH to complex I thus supporting a critical role in mitochondrial energy production and cellular survival. Acetyl Coenzyme A 114-124 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 0-22 30881593-1 2019 Pyruvate dehydrogenase (PDH) complex, a multienzyme complex at the nexus of glycolytic and Krebs cycles, provides acetyl-CoA to the Krebs cycle and NADH to complex I thus supporting a critical role in mitochondrial energy production and cellular survival. Acetyl Coenzyme A 114-124 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 24-27 29610354-5 2018 The method also allowed for the estimation of pyruvate dehydrogenase (PDH) enzyme activity through monitoring of the acetyl-CoA formation, independent of competing cytosolic metabolism. Acetyl Coenzyme A 117-127 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 46-68 29610354-5 2018 The method also allowed for the estimation of pyruvate dehydrogenase (PDH) enzyme activity through monitoring of the acetyl-CoA formation, independent of competing cytosolic metabolism. Acetyl Coenzyme A 117-127 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 70-73 28512002-7 2017 PDH catalyzes the oxidative decarboxylation of pyruvate into acetyl CoA, SDH oxidizes succinate into fumarate, and HMGCS2 controls the synthesis of the ketone body beta-hydroxybutyrate. Acetyl Coenzyme A 61-71 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 0-3 27641336-6 2017 The miR-182-PDK4 axis regulates lung cancer cell growth by modulating the activity of PDH, the gatekeeping enzyme of pyruvate flux into acetyl-CoA, and subsequently de novo lipogenesis of cancer cells. Acetyl Coenzyme A 136-146 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 86-89 27179453-3 2016 PDKs, via regulation of PDH complex activity, orchestrate the conversion of pyruvate either aerobically to acetyl-CoA, or anaerobically to lactate. Acetyl Coenzyme A 107-117 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 24-27 26137220-1 2015 BACKGROUND: Pyruvate dehydrogenase (PDH) occupies a central node of intermediary metabolism, converting pyruvate to acetyl-CoA, thus committing carbon derived from glucose to an aerobic fate rather than an anaerobic one. Acetyl Coenzyme A 116-126 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 12-34 26137220-1 2015 BACKGROUND: Pyruvate dehydrogenase (PDH) occupies a central node of intermediary metabolism, converting pyruvate to acetyl-CoA, thus committing carbon derived from glucose to an aerobic fate rather than an anaerobic one. Acetyl Coenzyme A 116-126 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 36-39 26137220-9 2015 PDH suppression also shifted the source of lipogenic acetyl-CoA from glucose to glutamine, and this compensatory pathway required a net reductive isocitrate dehydrogenase (IDH) flux to produce a source of glutamine-derived acetyl-CoA for fatty acids. Acetyl Coenzyme A 53-63 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 0-3 25152236-1 2014 Pyruvate dehydrogenase E1alpha (PDHA1) is the first component enzyme of the pyruvate dehydrogenase (PDH) complex that transforms pyruvate, via pyruvate decarboxylation, into acetyl-CoA that is subsequently used by both the citric acid cycle and oxidative phosphorylation to generate ATP. Acetyl Coenzyme A 174-184 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 0-22 25152236-1 2014 Pyruvate dehydrogenase E1alpha (PDHA1) is the first component enzyme of the pyruvate dehydrogenase (PDH) complex that transforms pyruvate, via pyruvate decarboxylation, into acetyl-CoA that is subsequently used by both the citric acid cycle and oxidative phosphorylation to generate ATP. Acetyl Coenzyme A 174-184 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 76-98 25152236-1 2014 Pyruvate dehydrogenase E1alpha (PDHA1) is the first component enzyme of the pyruvate dehydrogenase (PDH) complex that transforms pyruvate, via pyruvate decarboxylation, into acetyl-CoA that is subsequently used by both the citric acid cycle and oxidative phosphorylation to generate ATP. Acetyl Coenzyme A 174-184 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 32-35 25088999-6 2014 PDH catalyzes the conversion of pyruvate to acetyl-coA, thus playing a key role in cellular energy metabolism. Acetyl Coenzyme A 44-54 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 0-3 24395925-2 2014 Emerging evidence suggests that this enzyme functions as a positive regulator of total body glucose tolerance and muscle activity of pyruvate dehydrogenase (PDH), a mitochondrial enzyme complex that promotes glucose oxidation and is feedback inhibited by acetyl-CoA. Acetyl Coenzyme A 255-265 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 133-155 24395925-2 2014 Emerging evidence suggests that this enzyme functions as a positive regulator of total body glucose tolerance and muscle activity of pyruvate dehydrogenase (PDH), a mitochondrial enzyme complex that promotes glucose oxidation and is feedback inhibited by acetyl-CoA. Acetyl Coenzyme A 255-265 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 157-160 22508045-2 2012 Dichloroacetate (DCA) is a drug which is able to shift pyruvate metabolism from lactate to acetyl-CoA (tricarboxylic acid cycle) by indirect activation of pyruvate dehydrogenase (PDH). Acetyl Coenzyme A 91-101 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 155-177 22508045-2 2012 Dichloroacetate (DCA) is a drug which is able to shift pyruvate metabolism from lactate to acetyl-CoA (tricarboxylic acid cycle) by indirect activation of pyruvate dehydrogenase (PDH). Acetyl Coenzyme A 91-101 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 179-182 21596918-1 2011 Pyruvate dehydrogenase (PDH) is a mitochondrial enzyme responsible for regulating the conversion of pyruvate to acetyl-CoA for use in the tricarboxylic acid cycle. Acetyl Coenzyme A 112-122 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 0-22 21596918-1 2011 Pyruvate dehydrogenase (PDH) is a mitochondrial enzyme responsible for regulating the conversion of pyruvate to acetyl-CoA for use in the tricarboxylic acid cycle. Acetyl Coenzyme A 112-122 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 24-27 19517265-1 2009 The pyruvate dehydrogenase (PDH) complex is a mitochondrial multienzyme that catalyses the irreversible oxidative decarboxylation of pyruvate to acetyl-CoA. Acetyl Coenzyme A 145-155 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 4-26 19517265-1 2009 The pyruvate dehydrogenase (PDH) complex is a mitochondrial multienzyme that catalyses the irreversible oxidative decarboxylation of pyruvate to acetyl-CoA. Acetyl Coenzyme A 145-155 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 28-31 19639391-1 2009 Pyruvate dehydrogenase (PDH) is a crucial multienzyme system linking glycolysis to the tricarboxylic acid cycle by catalysing the decarboxylation of pyruvate to acetyl-CoA. Acetyl Coenzyme A 161-171 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 0-22 19639391-1 2009 Pyruvate dehydrogenase (PDH) is a crucial multienzyme system linking glycolysis to the tricarboxylic acid cycle by catalysing the decarboxylation of pyruvate to acetyl-CoA. Acetyl Coenzyme A 161-171 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 24-27 19605760-4 2009 PDH activity was elevated (P < 0.05) at baseline prior to Mod(2) (2.1 +/- 0.6 vs. 1.2 +/- 0.3 mmol acetyl-CoA x min(-1) x kg wet wt(-1)), and the delay in attaining end-exercise activity was abolished. Acetyl Coenzyme A 102-112 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 0-3 20641814-3 2004 In mitochondria, one of the major pathways is the irreversible transformation of Pyr into acetyl-coenzyme A (acetyl-CoA) and CO2 by pyruvate dehydrogenase (PDH) in the presence of coenzyme nicotinamide adenine dinucleotide (NAD(+)/NADH). Acetyl Coenzyme A 109-119 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 156-159 17555402-5 2007 PDK1 phosphorylates and inactivates PDH, the mitochondrial enzyme that converts pyruvate into acetyl-CoA. Acetyl Coenzyme A 94-104 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 36-39 16517405-3 2006 PDK1 inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA. Acetyl Coenzyme A 96-106 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 39-61 16517405-3 2006 PDK1 inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA. Acetyl Coenzyme A 96-106 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 63-66 14966024-6 2004 PDH activity decreased from 0.88 +/- 0.11 mmol acetyl-CoA. Acetyl Coenzyme A 47-57 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 0-3 14641042-1 2003 During exercise in human skeletal muscle, the proportion of carbohydrate derived acetyl-CoA is determined at least in part by the activity of the PDH (pyruvate dehydrogenase) complex. Acetyl Coenzyme A 81-91 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 146-149 14641042-1 2003 During exercise in human skeletal muscle, the proportion of carbohydrate derived acetyl-CoA is determined at least in part by the activity of the PDH (pyruvate dehydrogenase) complex. Acetyl Coenzyme A 81-91 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 151-173 12467461-1 2002 Pyruvate conversion to acetyl-CoA by the pyruvate dehydrogenase (PDH) multienzyme complex is known as a key node in affecting the metabolic fluxes of animal cell culture. Acetyl Coenzyme A 23-33 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 41-63 12467461-1 2002 Pyruvate conversion to acetyl-CoA by the pyruvate dehydrogenase (PDH) multienzyme complex is known as a key node in affecting the metabolic fluxes of animal cell culture. Acetyl Coenzyme A 23-33 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 65-68 11102541-1 2000 The pyruvate dehydrogenase (PDH) complex is situated at a key position in energy metabolism and is responsible for the conversion of pyruvate to acetyl CoA. Acetyl Coenzyme A 145-155 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 4-26 11102541-1 2000 The pyruvate dehydrogenase (PDH) complex is situated at a key position in energy metabolism and is responsible for the conversion of pyruvate to acetyl CoA. Acetyl Coenzyme A 145-155 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 28-31 11001755-6 2000 DCA increased PDH activity at rest and at 1 min of exercise, resulting in increased acetyl-CoA concentration and acetylcarnitine concentration at rest and at 1 min. Acetyl Coenzyme A 84-94 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 14-17 10826498-7 2000 A decreased ratio can relieve the inhibition of PDH as shown by the transfer of acetyl groups from acetyl-CoA to carnitine, forming acetylcarnitine, a reaction catalyzed by carnitine acetyl-transferase. Acetyl Coenzyme A 99-109 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 48-51 10662717-7 2000 The increased PDH(a) may have resulted from alterations in the acetyl-CoA, ADP(f), pyruvate, NADH, and H(+) concentrations leading to a lower relative activity of PDH kinase, whereas the similar values at 75% VO(2 max) may have reflected maximal activation. Acetyl Coenzyme A 63-73 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 14-17 10516124-9 1999 Reduced PDH activity occurred with ACID and may have resulted from alterations in the concentrations of acetyl-CoA, free ADP, pyruvate, NADH, and H(+), leading to greater relative activity of the kinase. Acetyl Coenzyme A 104-114 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 8-11 9816911-10 1998 Phosphorylation of PDH inhibits the reaction converting pyruvate to acetyl-CoA, resulting in inhibition of energy metabolism and a decrease in acetylcholine, both of which are also characteristics of AD. Acetyl Coenzyme A 68-78 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 19-22 9562476-5 1998 In addition, we found that TPKI can phosphorylate and inactivate pyruvate dehydrogenase (PDH), which is expected to result in depletion of acetyl-CoA, a key substrate of acetyl choline synthesis. Acetyl Coenzyme A 139-149 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 65-87 9562476-5 1998 In addition, we found that TPKI can phosphorylate and inactivate pyruvate dehydrogenase (PDH), which is expected to result in depletion of acetyl-CoA, a key substrate of acetyl choline synthesis. Acetyl Coenzyme A 139-149 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 89-92