PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16857587-4	2006	In glycerol with ethanol, Acs1p is an alternate acetyl-CoA source for HATs.	Acetyl Coenzyme A	48-58	acetate--CoA ligase 1	Saccharomyces cerevisiae S288C	26-31	
34391805-7	2021	To increase the acetyl-CoA pool, the ACS1 gene coding for acetyl-CoA synthetase was also overexpressed in the DtEM strain.	Acetyl Coenzyme A	16-26	acetate--CoA ligase 1	Saccharomyces cerevisiae S288C	37-41	
24269999-2	2014	In this yeast, cytosolic acetyl-CoA synthesis and growth strictly depend on expression of either the Acs1 or Acs2 isoenzyme of acetyl-CoA synthetase (ACS).	Acetyl Coenzyme A	25-35	acetate--CoA ligase 1	Saccharomyces cerevisiae S288C	101-105	
21090257-5	2010	RESULTS: Compared to the parent strain, the overexpression of ACS1 and ACS2 led to: (1) The intracellular acetyl-CoA content increased by 2.	Acetyl Coenzyme A	106-116	acetate--CoA ligase 1	Saccharomyces cerevisiae S288C	62-66	
1363452-9	1992	Surprisingly, disruption of the ACS1 gene did not affect growth on media containing ethanol as the sole carbon source, demonstrating that there are alternative pathways leading to acetyl-CoA under these conditions.	Acetyl Coenzyme A	180-190	acetate--CoA ligase 1	Saccharomyces cerevisiae S288C	32-36	
33576609-2	2021	In order to increase the yield of acetyl-CoA, different terminators were used to optimize the expressions of acetyl-CoA synthetase (ACS1/2) and aldehyde dehydrogenase (ALD6) to increase the contents of acetyl-CoA in Saccharomyces cerevisiae.	Acetyl Coenzyme A	34-44	acetate--CoA ligase 1	Saccharomyces cerevisiae S288C	132-138	
33576609-2	2021	In order to increase the yield of acetyl-CoA, different terminators were used to optimize the expressions of acetyl-CoA synthetase (ACS1/2) and aldehyde dehydrogenase (ALD6) to increase the contents of acetyl-CoA in Saccharomyces cerevisiae.	Acetyl Coenzyme A	109-119	acetate--CoA ligase 1	Saccharomyces cerevisiae S288C	132-138	
33576609-3	2021	ATF1 coding AATase was coexpressed in expression cassettes of ACS1/ACS2 and ALD6 to promote the carbon flux toward ethyl acetate from acetyl-CoA.	Acetyl Coenzyme A	134-144	acetate--CoA ligase 1	Saccharomyces cerevisiae S288C	62-66	
22789476-4	2012	The acetyl-CoA synthetase gene, ACS1, from Saccharomyces cerevisiae and the ATP-citrate lyase gene, ACL, from Mus musculus were expressed to regulate the acetyl-CoA metabolism in Y. lipolytica WSH-Z06.	Acetyl Coenzyme A	4-14	acetate--CoA ligase 1	Saccharomyces cerevisiae S288C	32-36	
22789476-6	2012	Both of the ACS1 and ACL genes could increase the level of acetyl-CoA and enhance the alpha-KG production.	Acetyl Coenzyme A	59-69	acetate--CoA ligase 1	Saccharomyces cerevisiae S288C	12-16