PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20139635-3	2010	Acetyl-CoA carboxylase (ACC), consisting of two isoenzymes ACC1 and ACC2, mediates the conversion from acetyl-CoA to malonyl-CoA, and thus plays a key role for the regulation of lipogenesis.	Acetyl Coenzyme A	103-113	acetyl-CoA carboxylase beta	Homo sapiens	68-72	
16721829-7	2006	In both lean and obese subjects, expression of mitochondrial ACC2 was 20-fold greater than that of cytoplasmic ACC1, consistent with their hypothesized roles in synthesizing malonyl-CoA from acetyl-CoA for CPT1 regulation and lipogenesis, respectively.	Acetyl Coenzyme A	191-201	acetyl-CoA carboxylase beta	Homo sapiens	61-65	
19190759-1	2009	Acetyl-CoA carboxylases ACC1 and ACC2 catalyze the carboxylation of acetyl-CoA to malonyl-CoA, regulating fatty-acid synthesis and oxidation, and are potential targets for treatment of metabolic syndrome.	Acetyl Coenzyme A	68-78	acetyl-CoA carboxylase beta	Homo sapiens	33-37	
18452391-6	2008	Using this detection method for CoA, we measured the activity of sequential enzymes in the fatty acid synthesis pathway to develop an ACC2/FAS-coupled assay where ACC2 produces malonyl-CoA from acetyl-CoA.	Acetyl Coenzyme A	194-204	acetyl-CoA carboxylase beta	Homo sapiens	163-167	
17223360-23	2007	The recombinant enzyme is a soluble protein and has a K(m) value of 2 microM for acetyl-CoA, almost 30-fold lower than that reported for the truncated human ACC2.	Acetyl Coenzyme A	81-91	acetyl-CoA carboxylase beta	Homo sapiens	157-161	
18452391-6	2008	Using this detection method for CoA, we measured the activity of sequential enzymes in the fatty acid synthesis pathway to develop an ACC2/FAS-coupled assay where ACC2 produces malonyl-CoA from acetyl-CoA.	Acetyl Coenzyme A	194-204	acetyl-CoA carboxylase beta	Homo sapiens	134-138	
35406730-10	2022	The Acetyl-CoA metabolite was down-regulated in db/db mice, aligning with the human differential expression of the genes ACOX1 and ACACB.	Acetyl Coenzyme A	4-14	acetyl-CoA carboxylase beta	Homo sapiens	131-136