PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8091338-11	1993	Some P450 (3A, 1A, 2E, ...) are inducible by compounds such as phenobarbital, rifampicin, aromatic hydrocarbon, ethanol, or omeprazole.	Omeprazole	124-134	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	5-9	
8894508-1	1996	Omeprazole (OP) is a potent antiulcer drug that is metabolized by liver cytochrome P450 (P450) enzymes.	Omeprazole	0-10	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	89-93	
8647857-1	1996	Human P450 2C19 is selective for 4"-hydroxylation of S-mephenytoin and 5-hydroxylation of omeprazole, while the structurally homologous P450 2C9 has low activity toward these substrates.	Omeprazole	90-100	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	6-10	
8647857-3	1996	The 339 NH2-terminal amino acid residues (SRS-1-SRS-4) and amino acids 160-383 (SRS-2-SRS-5) of P450 2C19 conferred omeprazole 5-hydroxylase activity to P450 2C9.	Omeprazole	116-126	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	96-100	
8647857-3	1996	The 339 NH2-terminal amino acid residues (SRS-1-SRS-4) and amino acids 160-383 (SRS-2-SRS-5) of P450 2C19 conferred omeprazole 5-hydroxylase activity to P450 2C9.	Omeprazole	116-126	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	153-157	
8647857-7	1996	A combination of two mutations, Ile99 --> His and Ser200 --> Pro, converted P450 2C9 to an enzyme with a turnover number of omeprazole 5-hyrdroxylation, which resembled that of P450 /c19.	Omeprazole	130-140	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	82-86	
8647857-7	1996	A combination of two mutations, Ile99 --> His and Ser200 --> Pro, converted P450 2C9 to an enzyme with a turnover number of omeprazole 5-hyrdroxylation, which resembled that of P450 /c19.	Omeprazole	130-140	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	183-187	
8647857-11	1996	Our results thus indicate that amino acids 99, 220, and 221 are key residues that determine the specificity of P450 2C19 for omeprazole.	Omeprazole	125-135	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	111-115	
16415119-7	2006	A monoclonal antibody to CYP2B6 and the CYP3A inhibitor ketoconazole substantially inhibited R-138727 formation, whereas inhibitors of CYP2C9 (sulfaphenazole) and CYP2C19 (omeprazole) did not.	Omeprazole	172-182	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	25-31	
8894508-1	1996	Omeprazole (OP) is a potent antiulcer drug that is metabolized by liver cytochrome P450 (P450) enzymes.	Omeprazole	0-10	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	83-87	
22313038-3	2012	Omeprazole potently inhibited clopidogrel activation by CYP2C19 with an IC(50) of 12.8 mumol/L and more weakly inhibited that by CYP2B6 and CYP3A4.	Omeprazole	0-10	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	129-135	
27434302-14	2016	The changes in drug clearance correlated with the expression pattern of the specific P450 enzymes in case of Cyp1a2-caffeine and Cyp2c37-omeprazole.	Omeprazole	137-147	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	85-89	
25600204-2	2015	To evaluate time-dependent cytochrome P450 induction precisely, induction of CYP1A2, CYP2B6, and CYP3A4 mRNA was confirmed (>2-fold) by the treatment with omeprazole, phenobarbital, and rifampicin, respectively, for 24 or 48 h on day 3 from the start of culture.	Omeprazole	158-168	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	85-91	
24553381-5	2014	The results revealed that CYP1A2, CYP2B6, and CYP3A4 were induced (>2.0-fold) by omeprazole, phenobarbital, and rifampicin, respectively, in all the hepatocyte lots tested at enzyme activity level (23 lots) and mRNA level (8 lots).	Omeprazole	84-94	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	34-40	
23629159-2	2014	We hypothesized that CYP2C19 and CYP2B6 genetic polymorphisms influence the extent of induction of omeprazole metabolism by efavirenz.	Omeprazole	99-109	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	33-39	
20019244-2	2010	In the present study, we carefully analyzed mRNA expression and activity of the major P450s and their responsiveness to three prototypical inducers, phenobarbital, rifampicin, and omeprazole, in differentiated HepaRG cell cultures over a 4-week period after low and high seeding.	Omeprazole	180-190	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	86-91	
20019244-7	2010	Thus, CYP1A2, CYP2B6, and CYP3A4 were found to accurately respond to their respective prototypical inducers, i.e., omeprazole, phenobarbital, and rifampicin.	Omeprazole	115-125	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	14-20