PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34619097-0 2021 Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability. Pyruvic Acid 29-37 Ras homolog enriched in brain Mus musculus 0-4 34619097-3 2021 Using SC-specific Rheb knockout mice, we demonstrate that Rheb-regulated mitochondrial pyruvate metabolism is critical for SC-mediated non-cell-autonomous regulation of peripheral axon stability. Pyruvic Acid 87-95 Ras homolog enriched in brain Mus musculus 18-22 34619097-3 2021 Using SC-specific Rheb knockout mice, we demonstrate that Rheb-regulated mitochondrial pyruvate metabolism is critical for SC-mediated non-cell-autonomous regulation of peripheral axon stability. Pyruvic Acid 87-95 Ras homolog enriched in brain Mus musculus 58-62 34619097-4 2021 Rheb knockout suppresses pyruvate dehydrogenase (PDH) activity (independently of mTORC1) and shifts pyruvate metabolism toward lactate production in SCs. Pyruvic Acid 100-108 Ras homolog enriched in brain Mus musculus 0-4