PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12824454-10	2003	Single RyR channel recordings revealed a approximately 60% reduction of the open probability of the channel by pyruvate (1 mM), but no change in conductance.	Pyruvic Acid	111-119	ryanodine receptor 2	Rattus norvegicus	7-10	
12824454-11	2003	This effect of pyruvate on RyR channel activity was neither Ca2+ nor ATP dependent.	Pyruvic Acid	15-23	ryanodine receptor 2	Rattus norvegicus	27-30	
12824454-12	2003	Taken together, these findings suggest that, in cardiac tissue, pyruvate has a dual effect on SR Ca2+ release consisting of a direct inhibition of RyR channel activity and elevation of SR Ca2+ content.	Pyruvic Acid	64-72	ryanodine receptor 2	Rattus norvegicus	147-150