PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25547679-2 2015 Through a large-scale synthetic lethal RNAi screen, we identified pyruvate dehydrogenase, the limiting enzyme for pyruvate entry into the mitochondrial tricarboxylic acid cycle, as critical for the survival of chronic myelogenous leukemia (CML) cells upon BCR-ABL inhibition. Pyruvic Acid 66-74 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 256-263 27055152-7 2016 Lactate and pyruvate levels were increased in BCR-ABL-expressing cells even under normoxia, coinciding with enhanced glutaminolysis which occurred in an HIF1/2-dependent manner. Pyruvic Acid 12-20 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 46-53