PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11378208-0 2001 Distinct effect of diazoxide on insulin secretion stimulated by protein kinase A and protein kinase C in rat pancreatic islets. Diazoxide 19-28 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 64-80 11378208-3 2001 In the present study, we examined the effect of lower (100 microM) and higher (250 microM) concentrations of diazoxide on insulin release by protein kinase A (PKA) and protein kinase C (PKC) activation. Diazoxide 109-118 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 141-157 11378208-3 2001 In the present study, we examined the effect of lower (100 microM) and higher (250 microM) concentrations of diazoxide on insulin release by protein kinase A (PKA) and protein kinase C (PKC) activation. Diazoxide 109-118 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 159-162 11378208-5 2001 Under this condition, 250 microM diazoxide inhibited insulin release enhanced by PKA activation but not that by PKC. Diazoxide 33-42 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 81-84 11378208-10 2001 These data suggest that insulin release stimulated by PKA and PKC activation under diazoxide is dependent on glucose metabolism, and that a signal derived from proximal steps in glycolysis may be necessary for the secretion by PKA activation. Diazoxide 83-92 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 54-57