PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17825556-6 2008 The Kir6.2/SUR1-2B agonist diazoxide activated K(ATP) channels in normokalaemic and K(+)-depleted rats with equal potency and efficacy. Diazoxide 27-36 potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus 4-10 12213059-4 2002 6-Chloro-3-(1-methylcyclobutyl)amino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide (54) was found to bind and activate the SUR1/Kir6.2 K(ATP) channels in the low nanomolar range and to be at least 1000 times more potent than the reference compound diazoxide with respect to inhibition of insulin release from rat islets. Diazoxide 249-258 potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus 129-135 9914396-9 1999 Furthermore, in four out of seven control cells tested, outward K+ currents were stimulated by diazoxide, which is a potent K+ channel-opening drug for the constructed SUR1/Kir6.2 and SUR2B/Kir6.2 channels, but not for the SUR2A/Kir6.2 channel. Diazoxide 95-104 potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus 173-179 9914396-9 1999 Furthermore, in four out of seven control cells tested, outward K+ currents were stimulated by diazoxide, which is a potent K+ channel-opening drug for the constructed SUR1/Kir6.2 and SUR2B/Kir6.2 channels, but not for the SUR2A/Kir6.2 channel. Diazoxide 95-104 potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus 190-196 9914396-9 1999 Furthermore, in four out of seven control cells tested, outward K+ currents were stimulated by diazoxide, which is a potent K+ channel-opening drug for the constructed SUR1/Kir6.2 and SUR2B/Kir6.2 channels, but not for the SUR2A/Kir6.2 channel. Diazoxide 95-104 potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus 190-196 16143577-10 2005 Ischaemic and pharmacological preconditioning with diazoxide and isoflurane induced ischaemic tolerance in the cultured neurones via mitoK(ATP) channels without an increase in Kir6.2 expression, and induced upregulation of EAAC1 expression. Diazoxide 51-60 potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus 176-182