PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15130761-0	2004	Diazoxide affects the IF1 inhibitor protein binding to F1 sector of beef heart F0F1ATPsynthase.	Diazoxide	0-9	ATP synthase inhibitory factor subunit 1	Homo sapiens	22-25	
15130761-2	2004	Here, we demonstrate that diazoxide directly interacts with the F(1) sector of beef heart F(0)F(1)ATPsynthase markedly promoting the binding of the inhibitor protein (IF(1)) to beta subunit.	Diazoxide	26-35	ATP synthase inhibitory factor subunit 1	Homo sapiens	167-172	
15130761-3	2004	More specifically, the treatment of soluble F(1) with one equivalent of diazoxide was sufficient to decrease the K(d) of IF(1)-F(1) complex at low pH.	Diazoxide	72-81	ATP synthase inhibitory factor subunit 1	Homo sapiens	121-126	
15130761-8	2004	These results suggest that diazoxide binds to beta subunit at NBD, which is highly conserved in the ATP-binding cassette protein family, thus inducing nucleotide stabilisation and favouring F(1) conformation suitable for IF(1) binding.	Diazoxide	27-36	ATP synthase inhibitory factor subunit 1	Homo sapiens	221-226	
15130761-9	2004	Finally, diazoxide also increased IF(1) binding to membrane bound F(1), while it did not influence the energisation-dependent IF(1) release.	Diazoxide	9-18	ATP synthase inhibitory factor subunit 1	Homo sapiens	34-39