PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31695594-8	2019	Opioid tolerance was attenuated with intraplantar injection of SUR1 agonists, such as diazoxide and NN-414 (100 muM, 10 muL) compared to vehicle treated animals.	Diazoxide	86-95	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	63-67	
31067750-6	2019	In ex-vivo nerve recordings, administration of the SUR1 agonist diazoxide to peripheral nerve terminals decreased mechanically evoked potentials.	Diazoxide	64-73	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	51-55	
23871704-5	2013	RESULTS: Metabolic inhibitor (MI)-activated current was not significantly different from pinacidil (SUR2A-specific)-activated current, and both currents were larger than diazoxide (SUR1-specific)-activated current in both the atrium and the ventricle.	Diazoxide	170-179	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	181-185	
24998494-7	2014	Diazoxide (250-500x10(-6)M), a SUR1-2B/Kir6.2 channel opener, prevented the protein loss induced by STS in the slow-twitch muscle after 6h showing an EC50 of 1.35x10(-7)M and Emax of 75%, down-regulated the caspase-9 gene and enhanced the KATP currents.	Diazoxide	0-9	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	31-35	
23535164-5	2013	This study investigated the role of inhibition of SDH by diazoxide and its relationship to the SUR1 subunit.	Diazoxide	57-66	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	95-99	
23535164-9	2013	RESULTS: Both malonate and diazoxide inhibit SDH activity in mitochondria of wild-type mice and in mice lacking the SUR1 subunit (p < 0.05 vs control).	Diazoxide	27-36	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	116-120	
19746425-3	2010	The results showed that pretreatment with nonselective KCO pinacidil (Pin) or diazoxide (Dia), a KCO sensitive to Kir6.2/SUR1 K(ATP) channels, protected mesencephalic neurons, especially dopaminergic neurons, against MPP(+)-induced injury in a concentration-dependent manner.	Diazoxide	78-87	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	121-125	
20804990-8	2010	CONCLUSIONS: Diazoxide does not open the ventricular sarcolemmal adenosine triphosphate-sensitive potassium channel but provides volume homeostasis via an SUR1-dependent pathway in mouse ventricular myocytes, supporting a mechanism of action distinct from sarcolemmal adenosine triphosphate-sensitive potassium channel activation.	Diazoxide	13-22	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	155-159	
19746425-3	2010	The results showed that pretreatment with nonselective KCO pinacidil (Pin) or diazoxide (Dia), a KCO sensitive to Kir6.2/SUR1 K(ATP) channels, protected mesencephalic neurons, especially dopaminergic neurons, against MPP(+)-induced injury in a concentration-dependent manner.	Diazoxide	89-92	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	121-125	
17881521-3	2007	Whole-cell recordings from mouse enhanced green fluorescent protein-GnRH neurons revealed that the K(ATP) channel opener diazoxide induced an outward current that was antagonized by the sulfonylurea receptor 1 (SUR1) channel blocker tolbutamide.	Diazoxide	121-130	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	186-209	
19744493-8	2010	The absence of SUR1 resulted in loss of efficacy of diazoxide in SUR1(-/-) atria (APD 36.8+/-1.9 ms vs. 36.8+/-2.8 ms, respectively, NS).	Diazoxide	52-61	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	15-19	
19744493-8	2010	The absence of SUR1 resulted in loss of efficacy of diazoxide in SUR1(-/-) atria (APD 36.8+/-1.9 ms vs. 36.8+/-2.8 ms, respectively, NS).	Diazoxide	52-61	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	65-69	
17881521-3	2007	Whole-cell recordings from mouse enhanced green fluorescent protein-GnRH neurons revealed that the K(ATP) channel opener diazoxide induced an outward current that was antagonized by the sulfonylurea receptor 1 (SUR1) channel blocker tolbutamide.	Diazoxide	121-130	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	211-215	
17881521-4	2007	Single-cell reverse transcription (RT)-PCR revealed that the majority of GnRH neurons expressed Kir6.2 and SUR1 subunits, which correlated with the diazoxide/tolbutamide sensitivity.	Diazoxide	148-157	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	107-111	
10868950-7	2000	Kir6.2 subunits form the K+ ion-permeable pore and primarily confer inhibition of the channels by ATP, while SUR1 subunits confer activation of the channels by MgADP and K+ channel openers, such as diazoxide, as well as inhibition by sulfonylureas.	Diazoxide	198-207	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	109-113	
12511769-5	2003	The neuroprotective effects of intracerebroventricular injections of diazoxide, which selectively affects mitochondria versus opening SUR1-type K(ATP) channels, and 5-hydroxydecanoate, a selective blocker of mitoK(ATP) channels, were evaluated with the same protocol.	Diazoxide	69-78	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	134-138