PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21075090-0 2011 AIF-mediated mitochondrial pathway is critical for the protective effect of diazoxide against SH-SY5Y cell apoptosis. Diazoxide 76-85 apoptosis inducing factor mitochondria associated 1 Homo sapiens 0-3 21075090-5 2011 Compared to cells induced by OGD alone, cells pretreated with diazoxide displayed reduced rates of apoptosis, increased mitochondrial transmembrane potential (DeltaPsim), and reduced AIF translocation to the cell nucleus. Diazoxide 62-71 apoptosis inducing factor mitochondria associated 1 Homo sapiens 183-186 21075090-7 2011 Meanwhile, cell death was blocked in OGD-induced cells stably transfected with the AIF-shRNA plasmid, and down-regulation of AIF reduced the diazoxide-mediated prevention of cell apoptosis as well as the loss of DeltaPsim induced by OGD. Diazoxide 141-150 apoptosis inducing factor mitochondria associated 1 Homo sapiens 83-86 21075090-7 2011 Meanwhile, cell death was blocked in OGD-induced cells stably transfected with the AIF-shRNA plasmid, and down-regulation of AIF reduced the diazoxide-mediated prevention of cell apoptosis as well as the loss of DeltaPsim induced by OGD. Diazoxide 141-150 apoptosis inducing factor mitochondria associated 1 Homo sapiens 125-128 21075090-8 2011 Taken together, our results demonstrate for the first time that the AIF-mediated mitochondrial pathway plays a critical role in the protective effect of diazoxide against SH-SY5Y cell apoptosis induced by OGD. Diazoxide 153-162 apoptosis inducing factor mitochondria associated 1 Homo sapiens 68-71