PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1874263-4	1991	Theophylline increased mean resting heart rate (51 +/- 6 versus 67 +/- 13 beats.min-1, P less than 0.01), mean 24-h heart rate (51 +/- 6 versus 68 +/- 14 beats.min-1, P less than 0.01) and minimal 24-h heart rate (32 +/- 6 versus 42 +/- 11 beats.min-1, P less than 0.01).	Theophylline	0-12	CD59 molecule (CD59 blood group)	Homo sapiens	80-85	
11350278-4	2001	theophylline decreased (P < 0.003) femoral artery blood flow (FaBF) by approximately 20%, i.e. from 3.6 +/- 0.5 to 2.9 +/- 0.5 L min(-1), and leg vascular conductance (VC) from 33.4 +/- 9.1 to 27.7 +/- 8.5 mL min-1 mmHg-1, whereas heart rate (HR), mean arterial pressure (MAP), leg oxygen uptake and lactate release remained unaltered (P = n.s.).	Theophylline	0-12	CD59 molecule (CD59 blood group)	Homo sapiens	132-138	
8619329-8	1995	Theophylline, at a dose lacking effects on myocardial work, markedly attenuated the coronary flow response to exogenous adenosine, and decreased CS flow to 89 (58-119), 120 (79-161) and 190 (162-218) mL min-1 at normoxic rest, hypoxic rest and hypoxic exercise, respectively.	Theophylline	0-12	CD59 molecule (CD59 blood group)	Homo sapiens	203-208	
8866596-9	1996	The mean morning PEF increased from 337 L x min-1 in the salmeterol group and 332 L x min-1 in the theophylline group to 372 and 357 L x min-1, respectively.	Theophylline	99-111	CD59 molecule (CD59 blood group)	Homo sapiens	86-91	
8866596-9	1996	The mean morning PEF increased from 337 L x min-1 in the salmeterol group and 332 L x min-1 in the theophylline group to 372 and 357 L x min-1, respectively.	Theophylline	99-111	CD59 molecule (CD59 blood group)	Homo sapiens	86-91	
1874263-4	1991	Theophylline increased mean resting heart rate (51 +/- 6 versus 67 +/- 13 beats.min-1, P less than 0.01), mean 24-h heart rate (51 +/- 6 versus 68 +/- 14 beats.min-1, P less than 0.01) and minimal 24-h heart rate (32 +/- 6 versus 42 +/- 11 beats.min-1, P less than 0.01).	Theophylline	0-12	CD59 molecule (CD59 blood group)	Homo sapiens	160-165	
1874263-4	1991	Theophylline increased mean resting heart rate (51 +/- 6 versus 67 +/- 13 beats.min-1, P less than 0.01), mean 24-h heart rate (51 +/- 6 versus 68 +/- 14 beats.min-1, P less than 0.01) and minimal 24-h heart rate (32 +/- 6 versus 42 +/- 11 beats.min-1, P less than 0.01).	Theophylline	0-12	CD59 molecule (CD59 blood group)	Homo sapiens	160-165	
2257859-3	1990	Morning peak expiratory flow (PEF) was slightly but significantly higher with theophylline (363 l.min-1) than terbutaline (342 l.min-1).	Theophylline	78-90	CD59 molecule (CD59 blood group)	Homo sapiens	98-103	
1983143-10	1990	After oral administration, renal clearance of theophylline was higher at steady state than after a single dose (0.58 +/- 0.06 L h-1 kg-1 vs 0.23 +/- 0.03 L h-1 kg-1), while urine flow rate was lower (1.1 +/- 0.5 mL min-1 vs 1.8 +/- 0.9 mL min-1).	Theophylline	46-58	CD59 molecule (CD59 blood group)	Homo sapiens	215-220	
1983143-10	1990	After oral administration, renal clearance of theophylline was higher at steady state than after a single dose (0.58 +/- 0.06 L h-1 kg-1 vs 0.23 +/- 0.03 L h-1 kg-1), while urine flow rate was lower (1.1 +/- 0.5 mL min-1 vs 1.8 +/- 0.9 mL min-1).	Theophylline	46-58	CD59 molecule (CD59 blood group)	Homo sapiens	239-244	
2643255-7	1989	Theophylline, at a dose blocking the coronary flow response to dipyridamole (an adenosine-dependent mechanism), induced a moderate increase in myocardial oxygen extraction (by 11%, P less than 0.05), but failed to affect either the basal coronary flow (105 +/- 16 ml min-1) or the increase during exercise (88 +/- 25 ml min-1).	Theophylline	0-12	CD59 molecule (CD59 blood group)	Homo sapiens	267-272	
2643255-7	1989	Theophylline, at a dose blocking the coronary flow response to dipyridamole (an adenosine-dependent mechanism), induced a moderate increase in myocardial oxygen extraction (by 11%, P less than 0.05), but failed to affect either the basal coronary flow (105 +/- 16 ml min-1) or the increase during exercise (88 +/- 25 ml min-1).	Theophylline	0-12	CD59 molecule (CD59 blood group)	Homo sapiens	320-325	
2923963-2	1989	The control mean theophylline half-life and clearance were 7.32 h and 0.86 ml min-1 kg-1, respectively.	Theophylline	17-29	CD59 molecule (CD59 blood group)	Homo sapiens	78-88	
1277710-4	1976	The body clearance of theophylline was appreciably larger and relatively more variable in smokers (100 +/-44 ml/min/1.73 m2) than in nonsmokers (45 +/-13 ml/min/1.73 m2).	Theophylline	22-34	CD59 molecule (CD59 blood group)	Homo sapiens	112-117	
1277710-4	1976	The body clearance of theophylline was appreciably larger and relatively more variable in smokers (100 +/-44 ml/min/1.73 m2) than in nonsmokers (45 +/-13 ml/min/1.73 m2).	Theophylline	22-34	CD59 molecule (CD59 blood group)	Homo sapiens	157-162	
31558088-6	2021	Theophylline administration was associated with significantly decreased serum creatinine levels (MD: -0.57 mg/dl, 95% CI: [-0.68, -0.46]) and elevated glomerular filtration rate (MD: 13.79 ml/min/1.73 m2, 95% CI: [11.91, 15.68]) in the third day of life.	Theophylline	0-12	CD59 molecule (CD59 blood group)	Homo sapiens	192-197	
2893637-3	1987	The mean total body clearance of theophylline was reduced from 57.6 ml min-1 before cimetidine to 39.5 ml min-1 during cimetidine; and the half-life was prolonged from 8.7 h before cimetidine to 12 h during cimetidine.	Theophylline	33-45	CD59 molecule (CD59 blood group)	Homo sapiens	71-76	
2893637-3	1987	The mean total body clearance of theophylline was reduced from 57.6 ml min-1 before cimetidine to 39.5 ml min-1 during cimetidine; and the half-life was prolonged from 8.7 h before cimetidine to 12 h during cimetidine.	Theophylline	33-45	CD59 molecule (CD59 blood group)	Homo sapiens	106-111	
3582518-6	1987	Theophylline increased the hypokalaemia, tachycardia and rise in systolic blood pressure which occurs in response to intravenous infusion of doses of L-adrenaline (0.02-0.06 microgram kg-1 min-1).	Theophylline	0-12	CD59 molecule (CD59 blood group)	Homo sapiens	189-194	
4019794-6	1985	The in vitro release rate of theophylline from freshly prepared formulations was, however, higher (4.8 mg min-1) from aminophylline suppositories relative to those containing theophylline (2.9 mg min-1).	Theophylline	29-41	CD59 molecule (CD59 blood group)	Homo sapiens	106-111