PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16133968-9 2005 Treatment with TNF-Ab, theophylline, or pentoxifylline significantly reduced serum/tissue TNF-alpha, IL-1beta, nitrate/nitrite, and iNOS expression. Theophylline 23-35 tumor necrosis factor Rattus norvegicus 90-99 26349791-11 2015 l-Arginine 100mg/kg+theophylline 20mg/kg suppressed TNF-alpha and elevates IL-10 level as well as reversed adjuvant-induced elevated arthritic parameters as compared to only adjuvant and prednisone group (p<0.001). Theophylline 20-32 tumor necrosis factor Rattus norvegicus 52-61 26349791-13 2015 Treatment with theophylline 20mg/kg significantly reduces synovial TNF-alpha level as compared to adjuvant only group. Theophylline 15-27 tumor necrosis factor Rattus norvegicus 67-76 28351778-9 2017 Theophylline treatment also reduced MPO activity and tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1 beta) and interleukin 6 (IL-6) concentrations in inflamed colon. Theophylline 0-12 tumor necrosis factor Rattus norvegicus 53-80 28351778-9 2017 Theophylline treatment also reduced MPO activity and tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1 beta) and interleukin 6 (IL-6) concentrations in inflamed colon. Theophylline 0-12 tumor necrosis factor Rattus norvegicus 82-91 8162974-6 1994 Comparable levels of inhibition of TNF-alpha release were observed on rat BMo and AM (rat BMo 42 +/- 4.9% of controls; rat AM 38 +/- 1.7% of controls), suggesting that BMo and AM are equally susceptible to suppression of TNF-alpha release induced by theophylline. Theophylline 250-262 tumor necrosis factor Rattus norvegicus 35-44 10027094-4 1999 The PDE inhibitors, rolipram (3 and 5 mg/kg) and theophylline (30 and 100 mg/kg) inhibited neutrophil recruitment, TNF-alpha release and cellular activation in BAL. Theophylline 49-61 tumor necrosis factor Rattus norvegicus 115-124 8162974-7 1994 These results indicate that theophylline suppresses TNF-alpha release by mononuclear phagocytes. Theophylline 28-40 tumor necrosis factor Rattus norvegicus 52-61 8162974-8 1994 Since TNF-alpha is involved in the pathogenesis of bronchial hyperresponsiveness and asthma, our results suggest that the therapeutic activity of theophylline might be partly related to its effect on TNF-alpha release. Theophylline 146-158 tumor necrosis factor Rattus norvegicus 6-15 8162974-8 1994 Since TNF-alpha is involved in the pathogenesis of bronchial hyperresponsiveness and asthma, our results suggest that the therapeutic activity of theophylline might be partly related to its effect on TNF-alpha release. Theophylline 146-158 tumor necrosis factor Rattus norvegicus 200-209 2844899-7 1988 In contrast, agents increasing intracellular cAMP concentrations such as PGE1, higher PGE2 doses, isoproterenol, and theophylline, all suppressed TNF-alpha synthesis. Theophylline 117-129 tumor necrosis factor Rattus norvegicus 146-155 29456664-8 2018 In the Jinwei Tang + budesonide and theophylline + budesonide groups, IL-8 and TNF-alpha expression was significantly decreased (P<0.05) and the HDAC2 level increased (P<0.05) compared with that in the COPD group. Theophylline 36-48 tumor necrosis factor Rattus norvegicus 79-88