PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9650124-9 1998 Theophylline prevented the decline of GFR, the increase of urinary beta 2-M and THP and the reduction of plasma EPO and PRA. Theophylline 0-12 erythropoietin Homo sapiens 112-115 19883252-1 2009 The aim of the present study was to investigate the influence of Eudragit E PO on the drug release mechanism of Eudragit L 100-55 film coatings applied to theophylline tablets by a dry powder coating technique. Theophylline 155-167 erythropoietin Homo sapiens 74-78 9625339-0 1998 Comparison of the effects of theophylline and caffeine on serum erythropoietin concentration in premature infants. Theophylline 29-41 erythropoietin Homo sapiens 64-78 9625339-1 1998 UNLABELLED: Theophylline administration has been shown to attenuate erythropoietin (EP) production in adults; the effect of caffeine is not known. Theophylline 12-24 erythropoietin Homo sapiens 68-82 9625339-1 1998 UNLABELLED: Theophylline administration has been shown to attenuate erythropoietin (EP) production in adults; the effect of caffeine is not known. Theophylline 12-24 erythropoietin Homo sapiens 84-86 9625339-2 1998 Our aim was to determine whether caffeine and theophylline had similar effects on EP production in the premature newborn. Theophylline 46-58 erythropoietin Homo sapiens 82-84 7781203-6 1995 Another therapeutic aspect derives from experimental and clinical data showing that theophylline controls erythropoietin production in erythrocytosis after renal transplantation. Theophylline 84-96 erythropoietin Homo sapiens 106-120 9414308-0 1998 Congenital erythropoietin-dependent erythrocytosis responsive to theophylline treatment. Theophylline 65-77 erythropoietin Homo sapiens 11-25 9549290-7 1997 Patients treated with theophylline showed a significant reduction of Hct values causing a reduction of erythropoietin serum level in 8/13 patients. Theophylline 22-34 erythropoietin Homo sapiens 103-117 9224226-2 1997 Theophylline has recently been shown to reduce hematocrit and erythropoietin blood levels in normal subjects and in patients with erythrocytosis after renal transplantation. Theophylline 0-12 erythropoietin Homo sapiens 62-76 8524479-10 1995 Theophylline and angiotensin converting enzyme inhibitors, which attenuate Epo production, can be used to treat PTE. Theophylline 0-12 erythropoietin Homo sapiens 75-78 7617113-6 1995 After an 8-week course of theophylline treatment (Theodur 300 mg x 2 daily), the mean serum erythropoietin levels were significantly reduced (from 61 mIU/ml before to 16.5 mIU/ml after treatment, p < 0.05). Theophylline 26-38 erythropoietin Homo sapiens 92-106 7617113-6 1995 After an 8-week course of theophylline treatment (Theodur 300 mg x 2 daily), the mean serum erythropoietin levels were significantly reduced (from 61 mIU/ml before to 16.5 mIU/ml after treatment, p < 0.05). Theophylline 50-57 erythropoietin Homo sapiens 92-106 7617113-10 1995 It is suggested that theophylline modulates the production of erythropoietin as well as the hematocrit levels in patients with erythrocytosis after renal transplantation and may be useful in the treatment of this condition. Theophylline 21-33 erythropoietin Homo sapiens 62-76 8197042-0 1994 The effect of short-term administration of theophylline on erythropoietin levels in healthy adults. Theophylline 43-55 erythropoietin Homo sapiens 59-73 7978058-5 1994 RESULTS: Phlebotomies produced a three- to sixfold increase of s-Epo, and a 6-week course of theophylline caused a decrease of both s-Epo and hemoglobin. Theophylline 93-105 erythropoietin Homo sapiens 134-137 8140628-6 1994 The patients were divided into 3 groups according to their response: (1) patients with high erythropoietin levels whose hematocrit decreased from 59.6% to 46.3% within 2 weeks of treatment in parallel with a fall in erythropoietin; (2) patients with normal erythropoietin levels in whom theophylline therapy reduced the hematocrit from 58.7% to 47.2%; and (3) patients in whom theophylline had no effect on their erythrocytosis. Theophylline 287-299 erythropoietin Homo sapiens 92-106 8140628-6 1994 The patients were divided into 3 groups according to their response: (1) patients with high erythropoietin levels whose hematocrit decreased from 59.6% to 46.3% within 2 weeks of treatment in parallel with a fall in erythropoietin; (2) patients with normal erythropoietin levels in whom theophylline therapy reduced the hematocrit from 58.7% to 47.2%; and (3) patients in whom theophylline had no effect on their erythrocytosis. Theophylline 377-389 erythropoietin Homo sapiens 92-106 8197042-1 1994 A previous study demonstrated suppression of erythropoietin production in patients treated with long-term theophylline. Theophylline 106-118 erythropoietin Homo sapiens 45-59 8197042-3 1994 In this pilot project we evaluated the effect of short-term theophylline administration on serum erythropoietin in healthy adults. Theophylline 60-72 erythropoietin Homo sapiens 97-111 8318681-11 1993 Theophylline, which reduces adenosine-mediated erythropoietin synthesis, is effective but may be associated with side effects. Theophylline 0-12 erythropoietin Homo sapiens 47-61 8283362-0 1994 Erythropoietin levels during theophylline treatment in premature infants. Theophylline 29-41 erythropoietin Homo sapiens 0-14 8283362-1 1994 Mean erythropoietin levels were somewhat higher in premature infants receiving theophylline than in untreated infants with a comparable degree of anemia. Theophylline 79-91 erythropoietin Homo sapiens 5-19 8190338-3 1994 Hence, a trial with oral theophylline was performed in the three patients, resulting in a sustained decrease of the haematocrit (from 43.6 to 33%) and endogenous erythropoietin (from 46 to 15 mU/ml) levels. Theophylline 25-37 erythropoietin Homo sapiens 162-176 2163024-0 1990 Effects of theophylline on erythropoietin production in normal subjects and in patients with erythrocytosis after renal transplantation. Theophylline 11-23 erythropoietin Homo sapiens 27-41 2163024-3 1990 RESULTS: After an eight-week course of theophylline treatment, the mean (+/- SEM) serum erythropoietin levels were significantly reduced in both the renal-transplant recipients (from 60 +/- 14 units per liter at base line to 9 +/- 7 units after treatment; P less than 0.05) and the normal subjects (from 6.9 +/- 0.8 units per liter at base line to 4.7 +/- 0.5 units per liter after treatment; P less than 0.05). Theophylline 39-51 erythropoietin Homo sapiens 88-102 2163024-9 1990 CONCLUSIONS: Theophylline attenuates the production of erythropoietin in both normal subjects and patients with erythrocytosis after renal transplantation and may be useful in the treatment of the latter condition. Theophylline 13-25 erythropoietin Homo sapiens 55-69