PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10836323-0 1999 Theophylline induces a reduction in circulating interleukin-4 and interleukin-5 in atopic asthmatics. Theophylline 0-12 interleukin 4 Homo sapiens 48-61 10836323-3 1999 This study investigated whether theophylline administration has an impact on serum levels of interleukin (IL)-4 and IL-5 in asthmatic patients. Theophylline 32-44 interleukin 4 Homo sapiens 93-111 10836323-8 1999 In conclusion, the administration of a low, single, daily dose of oral theophylline in asymptomatic patients with mild atopic asthma seems to reduce circulating interleukin-4 and interleukin-5. Theophylline 71-83 interleukin 4 Homo sapiens 161-174 9641578-14 1998 The production of these cytokines was significantly suppressed by the anti-asthma drugs theophylline (IL-4, p<0.001, n=6; IL-13, p<0.001, n=10) and dexamethasone (IL-4, p<0.001, n=15; IL-13, p<0.001, n=10). Theophylline 88-100 interleukin 4 Homo sapiens 102-106 12840867-0 1999 Effects of theophylline on plasma levels of interleukin-4, cyclic nucleotides and pulmonary functions in patients with chronic obstructive pulmonary disease. Theophylline 11-23 interleukin 4 Homo sapiens 44-57 12840867-8 1999 We are led to conclude that IL-4 might play a role in the pathogenesis of the airway inflammation and air flow limitation in COPD patients and the mechanisms of theophylline"s therapeutic effects of attenuating air-flow limitation may partially depend on its anti-inflammatory effects on the airways which, in turn, is dependent on its inhibitory effects on some inflammatory mediators such as IL-4. Theophylline 161-173 interleukin 4 Homo sapiens 28-32 12840867-8 1999 We are led to conclude that IL-4 might play a role in the pathogenesis of the airway inflammation and air flow limitation in COPD patients and the mechanisms of theophylline"s therapeutic effects of attenuating air-flow limitation may partially depend on its anti-inflammatory effects on the airways which, in turn, is dependent on its inhibitory effects on some inflammatory mediators such as IL-4. Theophylline 161-173 interleukin 4 Homo sapiens 394-398 9650812-5 1998 The beta-2 agonist salmeterol, the H1-receptor antagonist terfenadine and the phosphodiesterase inhibitor theophylline inhibited the release of IL-4 and IL-13 by more than 50% following 4 h of basophil stimulation with anti-IgE. Theophylline 106-118 interleukin 4 Homo sapiens 144-148 9641578-14 1998 The production of these cytokines was significantly suppressed by the anti-asthma drugs theophylline (IL-4, p<0.001, n=6; IL-13, p<0.001, n=10) and dexamethasone (IL-4, p<0.001, n=15; IL-13, p<0.001, n=10). Theophylline 88-100 interleukin 4 Homo sapiens 169-173 9641578-16 1998 The inhibitory effect of dexamethasone and theophylline on allergic inflammation may be due to the inhibition of IL-4 and IL-13 production not only by T cells but also by basophils. Theophylline 43-55 interleukin 4 Homo sapiens 113-117 8861748-6 1996 This study was designed to compare the effects of PDE inhibitors Ro20-1724 and theophylline on (1) the mitogenic response of peripheral blood mononuclear cells from atopic and non-atopic individuals and (2) secretion of IL-4 and IL-5 by TH(2) cells after activation with PMA and anti-CD3. Theophylline 79-91 interleukin 4 Homo sapiens 220-224 9414138-7 1997 A nonselective PDE inhibitor, theophylline, and a PDE IV-selective inhibitor, rolipram, significantly suppressed the release of IL-4 and IL-13 from the basophil-enriched preparation. Theophylline 30-42 interleukin 4 Homo sapiens 128-132 8822937-7 1996 Chlorambucil- and theophylline-induced apoptosis was partially inhibited by interleukin-4 (IL-4), which also abrogated the effects on oncogene expression. Theophylline 18-30 interleukin 4 Homo sapiens 76-89 8822937-7 1996 Chlorambucil- and theophylline-induced apoptosis was partially inhibited by interleukin-4 (IL-4), which also abrogated the effects on oncogene expression. Theophylline 18-30 interleukin 4 Homo sapiens 91-95 8866593-9 1996 This study shows an anti-inflammatory effect of theophylline in asthmatic bronchi, both in cell numbers and in the expression of IL-4, believed to be an important cytokine in the pathophysiology of asthmatic inflammation. Theophylline 48-60 interleukin 4 Homo sapiens 129-133 8861748-10 1996 In conclusion, as Ro20-1724 and theophylline inhibit proliferation of PBMC and secretion of IL-4 and IL-5 from human TH(2) cell lines, the development of a selective cyclic nucleotide PDE IV inhibitor may provide a promising new approach for asthma prophylaxis. Theophylline 32-44 interleukin 4 Homo sapiens 92-96 34414894-9 2021 The combination of theophylline and budesonide suppressed synthesis of IL-4 and CXCL8 by NK and NKT-like cells, as well as the production of TNFalpha and IFNgamma by NK cells stronger than budesonide alone. Theophylline 19-31 interleukin 4 Homo sapiens 71-75 7656958-7 1995 In addition, the numbers of cells containing cytokines, interleukin 4 and 5 (IL-4 and IL-5), decreased in the theophylline-treated group and increased in the placebo-treated group, with the difference between the changes being significant. Theophylline 110-122 interleukin 4 Homo sapiens 56-75 7656958-7 1995 In addition, the numbers of cells containing cytokines, interleukin 4 and 5 (IL-4 and IL-5), decreased in the theophylline-treated group and increased in the placebo-treated group, with the difference between the changes being significant. Theophylline 110-122 interleukin 4 Homo sapiens 77-81 1377987-4 1992 Here we show that IL-4-induced class II antigen expression on the HL-60 cell line or normal human monocytes is calcium/calmodulin-independent since theophylline (TPH, a calmodulin inhibitor) does not block the IL-4 effect. Theophylline 162-165 interleukin 4 Homo sapiens 18-22 34414894-7 2021 Azithromycin suppressed production of IL-4 and CXCL8 by NK and NKT-like cells, and theophylline inhibited IL-4 synthesis by these lymphocytes. Theophylline 83-95 interleukin 4 Homo sapiens 106-110 12771548-11 2003 Finally, theophylline inhibited the expression of ICAM-1 and VCAM-1 on HUVEC stimulated with IL-4 plus TNF-alpha. Theophylline 9-21 interleukin 4 Homo sapiens 93-97 15265810-3 2004 The nonselective PDE inhibitors, isobutyl-methylxanthine (IBMX) and theophylline, attenuated the IgE-mediated generation of IL-4 and IL-13 and, also, the release of histamine from basophils. Theophylline 68-80 interleukin 4 Homo sapiens 124-128 10596698-6 1999 Suppressed expression of IL-3 (36.9%), IL4 (38.8%), GM-CSF (24.6%) and IFN-gamma (37.7%), but not of IL-5, was only seen with theophylline at a concentration of 10(-3) M (180 microg x mL(-1)) (p<0.05) and not at lower concentrations. Theophylline 126-138 interleukin 4 Homo sapiens 39-42